Tim Sheahan
@timothysheahan.bsky.social
PI in #virology working on #coronavirus and #hepacivirus pathogenesis and #antivirals at UNC Chapel Hill. Featured in GQ mag (what the hell?) for #COVID19. Almost over the hill but still love Minor Threat.
New #coronavirus #postacute lung pathogenesis paper from my friend Dr. John Powers is up at @asm.org JVI. journals.asm.org/doi/10.1128/... Confusing as to why this link shows a rotund blue bird. #PASC #SARSCoV2 #Omicron #LoveVirology #JVI #ASM #virology
Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology
To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants
of concern, the development of effective small animal models is of critical importance.
Herein, we describe the de...
journals.asm.org
November 6, 2025 at 2:37 PM
New #coronavirus #postacute lung pathogenesis paper from my friend Dr. John Powers is up at @asm.org JVI. journals.asm.org/doi/10.1128/... Confusing as to why this link shows a rotund blue bird. #PASC #SARSCoV2 #Omicron #LoveVirology #JVI #ASM #virology
Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus
May 28, 2025 at 10:40 PM
Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus
New paper about ACE2 using Merbecovirus. Hot stuff. So hot but you can't Letko. @fviromics.bsky.social and Nick Catanzaro. www.nature.com/articles/s41... #ACE2 #emergingviruses #bats #batman #MERS #HKU5
ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses - Nature Communications
This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...
www.nature.com
May 28, 2025 at 6:15 PM
New paper about ACE2 using Merbecovirus. Hot stuff. So hot but you can't Letko. @fviromics.bsky.social and Nick Catanzaro. www.nature.com/articles/s41... #ACE2 #emergingviruses #bats #batman #MERS #HKU5
@mattfrieman.bsky.social taped this to my lab notebook almost 20 years ago. It’s not untrue 🤣Vestiges of simpler times. #lovevirology #virology #lablife #sars #laboratory #science #biology #academia
May 22, 2025 at 12:07 PM
@mattfrieman.bsky.social taped this to my lab notebook almost 20 years ago. It’s not untrue 🤣Vestiges of simpler times. #lovevirology #virology #lablife #sars #laboratory #science #biology #academia
So nice to be teamed up with @wrapplab.bsky.social on this mAb project! It's been a delight. Some may say a Wrapper's Delight? #antibodies #virology #lovevirology #229E #coronavirus #therapeutics #vaccination #emergingviruses
Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain
HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Althoug...
www.biorxiv.org
May 19, 2025 at 4:24 PM
So nice to be teamed up with @wrapplab.bsky.social on this mAb project! It's been a delight. Some may say a Wrapper's Delight? #antibodies #virology #lovevirology #229E #coronavirus #therapeutics #vaccination #emergingviruses
Reposted by Tim Sheahan
Reposted by Tim Sheahan
How much federal research funding has been axed so far in the new administration? An early estimate is $1.8B, but that's likely an underestimate, @aniloza.bsky.social reports. www.statnews.com/2025/05/08/t...
NIH grant terminations under Trump have totaled at least $1.8 billion, analysis finds
Researchers calculated that $1.8 billion in National Institutes of Health grants were terminated in just over one month
www.statnews.com
May 8, 2025 at 8:20 PM
How much federal research funding has been axed so far in the new administration? An early estimate is $1.8B, but that's likely an underestimate, @aniloza.bsky.social reports. www.statnews.com/2025/05/08/t...
How does one determine EC50 w a curve like this? #antivirals #coronavirus #cell www.sciencedirect.com/science/arti...
April 14, 2025 at 4:56 PM
How does one determine EC50 w a curve like this? #antivirals #coronavirus #cell www.sciencedirect.com/science/arti...
Thank you @holdenthorp.bsky.social for being a voice which eventually we can hopefully build into a chorus. It's hard to not fall into a daily bleakness black hole (DBBH).
April 8, 2025 at 12:58 AM
Thank you @holdenthorp.bsky.social for being a voice which eventually we can hopefully build into a chorus. It's hard to not fall into a daily bleakness black hole (DBBH).
Reposted by Tim Sheahan
NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-080: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health NOT-OD-25-080. OD
grants.nih.gov
March 29, 2025 at 8:04 PM
NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Tim Sheahan
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article)
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
nyti.ms
March 26, 2025 at 9:57 PM
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
The damage being done to the biomedical community will probably not be appreciated for years
...a “pointless, ill-advised move that will hurt U.S. science and pandemic readiness,” says Charles Rice, a Nobel Prize–winning virologist at Rockefeller University
www.science.org/content/arti...
www.science.org/content/arti...
Saying ‘pandemic is over,’ NIH institute starts cutting COVID-19 research
Grant terminations halt research on improving vaccinations and preventing future pandemics
www.science.org
March 25, 2025 at 10:50 PM
The damage being done to the biomedical community will probably not be appreciated for years
Reposted by Tim Sheahan
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
www.thetransmitter.org
February 18, 2025 at 11:39 PM
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
Saved from death in the paper grave yard! Started in 2016. MERS-CoV infects epithelial cells, they die, pathology is wicked bad. Adaptive immune cells both control replication and drive pathogenesis. #coronavirus #MERSCoV #pathogenesis #LoveVirology #viruses #virus journals.asm.org/eprint/ZZEIT...
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity | mSphere
Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease
outcomes in humans from an asymptomatic, moderate, and severe respiratory disease
that can progress to death but...
journals.asm.org
January 30, 2025 at 2:11 PM
Saved from death in the paper grave yard! Started in 2016. MERS-CoV infects epithelial cells, they die, pathology is wicked bad. Adaptive immune cells both control replication and drive pathogenesis. #coronavirus #MERSCoV #pathogenesis #LoveVirology #viruses #virus journals.asm.org/eprint/ZZEIT...
Reposted by Tim Sheahan
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
www.science.org
January 23, 2025 at 12:15 AM
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...
Just when you though Apple’s #Siri was the most annoying and egregiously offensive Siri…https://www.nytimes.com/2024/12/13/health/aaron-siri-rfk-jr-vaccines.html?smid=nytcore-ios-share&referringSource=articleShare&sgrp=c-cb
RFK Jr.’s Lawyer Has Asked the FDA to Revoke Polio Vaccine Approval
Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.
www.nytimes.com
December 13, 2024 at 1:10 PM
Just when you though Apple’s #Siri was the most annoying and egregiously offensive Siri…https://www.nytimes.com/2024/12/13/health/aaron-siri-rfk-jr-vaccines.html?smid=nytcore-ios-share&referringSource=articleShare&sgrp=c-cb
Reposted by Tim Sheahan
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
hr.myu.umn.edu
November 22, 2024 at 6:54 PM
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Firing forgotten neurons teaching my 12 year old daughter how to plate bacteria and calculate colony forming units! #stem #scienceolympiad #SciOly #cfu #ecoli #lablife #microbiology
November 18, 2024 at 9:38 PM
Firing forgotten neurons teaching my 12 year old daughter how to plate bacteria and calculate colony forming units! #stem #scienceolympiad #SciOly #cfu #ecoli #lablife #microbiology
Remember #coronaviruses? We need broad antivirals for #emergingviruses. Cool collab w Jim Sacchettini @ Texas A&M on a protease inhibitor #antiviral. HTS, structure guided med chem, in vitro, in vivo assays. www.cell.com/cell-reports...
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Zhou et al. describe NZ-804, a non-peptidic inhibitor of the SARS-CoV-2 Mpro. It shows
potent antiviral activity with low-nanomolar IC50 and EC50 in human lung cells and
primary airway epithelial cult...
www.cell.com
November 13, 2024 at 9:34 PM
Remember #coronaviruses? We need broad antivirals for #emergingviruses. Cool collab w Jim Sacchettini @ Texas A&M on a protease inhibitor #antiviral. HTS, structure guided med chem, in vitro, in vivo assays. www.cell.com/cell-reports...
#Cookie mitosis! Every year I make cookies for the #lab using my kid’s #Halloween haul. Too much damn candy. #lablife #lovevirology #biology #labculture #baking #bakingtherapy
November 13, 2024 at 9:27 PM
#Cookie mitosis! Every year I make cookies for the #lab using my kid’s #Halloween haul. Too much damn candy. #lablife #lovevirology #biology #labculture #baking #bakingtherapy
Following in Charlie's footsteps on the snack front because the science = hard 😭. As a #ricelab postdoc @ #rockefeller 10+ years ago there were always snacks to fuel #virology. Now I try to do small things like this for my people to brighten their day. #lablife #traderjoes #charlierice #labculture
November 13, 2024 at 9:23 PM
Following in Charlie's footsteps on the snack front because the science = hard 😭. As a #ricelab postdoc @ #rockefeller 10+ years ago there were always snacks to fuel #virology. Now I try to do small things like this for my people to brighten their day. #lablife #traderjoes #charlierice #labculture