Timothée Bruel
@timotheebruel.bsky.social
Group Leader / Antiviral Activities of Antibodies
@Virus_Immunity @institutpasteur - Virology/Immunology - Member
@SFV_France
@Virus_Immunity @institutpasteur - Virology/Immunology - Member
@SFV_France
Reposted by Timothée Bruel
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions journals.asm.org/doi/10.1128/...
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions | Journal of Virology
Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue
to pose a significant risk for future outbreaks through zoonotic transmissions. This
highlights the need for effect...
journals.asm.org
November 13, 2025 at 2:32 PM
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions journals.asm.org/doi/10.1128/...
Reposted by Timothée Bruel
Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge https://www.biorxiv.org/content/10.1101/2025.11.12.688003v1
November 13, 2025 at 6:16 PM
Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge https://www.biorxiv.org/content/10.1101/2025.11.12.688003v1
Reposted by Timothée Bruel
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 9, 2025 at 10:33 PM
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Our latest work on #COVID immunity and imprinting in humans.
Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others!
www.biorxiv.org/content/10.1...
Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others!
www.biorxiv.org/content/10.1...
Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans
The first exposure to a pathogen or an antigen profoundly impacts immune responses upon subsequent encounter with related pathogens. This immune imprinting explains that infection or vaccination with ...
www.biorxiv.org
October 21, 2025 at 3:42 AM
Our latest work on #COVID immunity and imprinting in humans.
Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others!
www.biorxiv.org/content/10.1...
Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others!
www.biorxiv.org/content/10.1...
Reposted by Timothée Bruel
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
Author summary Recent epidemic-causing coronaviruses, including SARS-CoV-2, originated in bats. Large numbers of such viruses circulate in bats and pose clear and present risks to humans. However, our...
journals.plos.org
October 17, 2025 at 3:51 PM
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
« A lineage that is virtually unchanged since 1976 challenges assumptions about Ebola's evolution and exposes the blind spots of surveillance. »
Ebola virus in Kasai revives 50-year-old questions on viral latency www.thelancet.com/journals/lan...
Ebola virus in Kasai revives 50-year-old questions on viral latency
On Sept 4, 2025, DR Congo declared its 16th Ebola virus outbreak. The epicentre of
this outbreak occurred in the Kasai province—the first resurgence in this region since
2008.1 Genomic analysis identi...
www.thelancet.com
October 18, 2025 at 1:00 AM
« A lineage that is virtually unchanged since 1976 challenges assumptions about Ebola's evolution and exposes the blind spots of surveillance. »
Reposted by Timothée Bruel
#NewResearch
Dipeptidase 1 is a functional receptor for a porcine coronavirus
@virusfusion007.bsky.social @jeremydufloo.bsky.social
#microsky
www.nature.com/articles/s41...
Dipeptidase 1 is a functional receptor for a porcine coronavirus
@virusfusion007.bsky.social @jeremydufloo.bsky.social
#microsky
www.nature.com/articles/s41...
Client Challenge
www.nature.com
October 13, 2025 at 5:06 PM
#NewResearch
Dipeptidase 1 is a functional receptor for a porcine coronavirus
@virusfusion007.bsky.social @jeremydufloo.bsky.social
#microsky
www.nature.com/articles/s41...
Dipeptidase 1 is a functional receptor for a porcine coronavirus
@virusfusion007.bsky.social @jeremydufloo.bsky.social
#microsky
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Dipeptidase 1 is a functional receptor for a porcine coronavirus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dipeptidase 1 is a functional receptor for a porcine coronavirus - Nature Microbiology
Characterization of dipeptidase 1 as a receptor for porcine haemagglutinating encephalomyelitis virus reveals the versatility of embecovirus receptor binding domains and receptor usage.
www.nature.com
October 10, 2025 at 6:09 PM
Dipeptidase 1 is a functional receptor for a porcine coronavirus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
« Our findings strongly implicate VZV reactivation as a modifiable risk factor for dementia. »
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
October 7, 2025 at 8:45 PM
« Our findings strongly implicate VZV reactivation as a modifiable risk factor for dementia. »
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains https://www.biorxiv.org/content/10.1101/2025.10.03.679858v1
October 7, 2025 at 3:16 AM
Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains https://www.biorxiv.org/content/10.1101/2025.10.03.679858v1
Reposted by Timothée Bruel
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 6:26 PM
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Timothée Bruel
New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
No evidence for human or rodent deltavirus replication in yeast | microPublication
doi.org
October 4, 2025 at 6:55 AM
New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
Reposted by Timothée Bruel
Read the associated research article here: www.nature.com/articles/s41...
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology
A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.
www.nature.com
October 1, 2025 at 5:55 PM
Read the associated research article here: www.nature.com/articles/s41...
Reposted by Timothée Bruel
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor @natmicrobiol.nature.com Microbiol
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology
A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.
www.nature.com
September 29, 2025 at 8:33 PM
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor @natmicrobiol.nature.com Microbiol
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
September 27, 2025 at 3:31 AM
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
Reposted by Timothée Bruel
HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 26, 2025 at 4:43 PM
HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
« Chromatin profiling revealed that IRF1 and IRF2 occupy the same ISG regulatory sites, but as a weaker transcriptional activator, IRF2 limited ISG transcription by IRF1. »
How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!
How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!
IRF2 degradation tunes the innate immune response https://www.biorxiv.org/content/10.1101/2025.09.23.678148v1
September 25, 2025 at 7:13 PM
« Chromatin profiling revealed that IRF1 and IRF2 occupy the same ISG regulatory sites, but as a weaker transcriptional activator, IRF2 limited ISG transcription by IRF1. »
How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!
How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!
Reposted by Timothée Bruel
The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy https://www.biorxiv.org/content/10.1101/2025.09.22.677905v1
September 25, 2025 at 1:15 AM
The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy https://www.biorxiv.org/content/10.1101/2025.09.22.677905v1
Reposted by Timothée Bruel
Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
September 25, 2025 at 6:34 AM
Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Timothée Bruel
Reposted by Timothée Bruel
#Comment
A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
A transatlantic joint lab model for interdisciplinary research - Nature Microbiology
A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current...
www.nature.com
September 22, 2025 at 3:36 PM
#Comment
A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.
#MicroSky #AcademicChatter
www.nature.com/articles/s41...
Reposted by Timothée Bruel
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response @natbiomedeng.nature.com @vanderbilt.edu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 23, 2025 at 2:35 PM
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response @natbiomedeng.nature.com @vanderbilt.edu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations www.science.org/doi/10.1126/...
Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations
Non-neutralizing antibodies to influenza A are broadly protective and resist viral escape, offering strong therapeutic potential.
www.science.org
September 15, 2025 at 5:57 PM
Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations www.science.org/doi/10.1126/...
Reposted by Timothée Bruel
Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease - Nature Microbiology
Salivary virome profiling revealed distinct virome profiles in Sjögren’s disease and a role for Vientovirus in triggering autoimmunity through molecular mimicry.
www.nature.com
September 9, 2025 at 12:38 PM
Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothée Bruel
Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity!
www.biorxiv.org/content/10.1101/2025.09.03.673949v1
www.biorxiv.org/content/10.1101/2025.09.03.673949v1
Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.
Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
www.biorxiv.org
September 9, 2025 at 1:46 PM
Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity!
www.biorxiv.org/content/10.1101/2025.09.03.673949v1
www.biorxiv.org/content/10.1101/2025.09.03.673949v1