Thomas Uslar
@thomasuslar.bsky.social
Academic Endocrinologist / Adrenal Team / @FacMedicinaUC Pontificia Universidad Católica de Chile
Reposted by Thomas Uslar
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
July 15, 2025 at 1:06 PM
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
Reposted by Thomas Uslar
In the @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team
Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)
#NephSky #EndoSky
www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team
Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)
#NephSky #EndoSky
Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0
Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...
www.acpjournals.org
May 6, 2025 at 10:34 AM
In the @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team
Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)
#NephSky #EndoSky
www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team
Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)
#NephSky #EndoSky
Reposted by Thomas Uslar
Mild autonomous cortisol secretion (MACS) associated with #unilateral #adrenal #incidentalomas is responsible for secondary #hypertension that can be safely improved by minimally-invasive #adrenalectomy www.thelancet.com/journals/lan...
#MedSky #EndoSky #OncSky #CardioSky
#MedSky #EndoSky #OncSky #CardioSky
Surgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomis...
MACS associated with unilateral adrenal incidentalomas is responsible for secondary
hypertension that can be safely improved by minimally-invasive adrenalectomy.
www.thelancet.com
May 12, 2025 at 10:43 PM
Mild autonomous cortisol secretion (MACS) associated with #unilateral #adrenal #incidentalomas is responsible for secondary #hypertension that can be safely improved by minimally-invasive #adrenalectomy www.thelancet.com/journals/lan...
#MedSky #EndoSky #OncSky #CardioSky
#MedSky #EndoSky #OncSky #CardioSky
Reposted by Thomas Uslar
ICYMI: New content online: Adrenocortical stem cells in health and disease
Adrenocortical stem cells in health and disease
Nature Reviews Endocrinology, Published online: 10 March 2025; doi:10.1038/s41574-025-01091-2This Review outlines the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche — comprising capsular stem cells and cortical…
www.nature.com
March 12, 2025 at 9:01 PM
ICYMI: New content online: Adrenocortical stem cells in health and disease
Reposted by Thomas Uslar
I’m thrilled to see our latest paper published in Hypertension! 🎉
lnkd.in/e5J92MWe
We developed a new adrenocortical cell model reproducing the major features of cells harboring a KCNJ5 mutation.
@aldolabz.bsky.social @parcc-inserm.bsky.social @upcite.bsky.social
lnkd.in/e5J92MWe
We developed a new adrenocortical cell model reproducing the major features of cells harboring a KCNJ5 mutation.
@aldolabz.bsky.social @parcc-inserm.bsky.social @upcite.bsky.social
March 17, 2025 at 9:37 PM
I’m thrilled to see our latest paper published in Hypertension! 🎉
lnkd.in/e5J92MWe
We developed a new adrenocortical cell model reproducing the major features of cells harboring a KCNJ5 mutation.
@aldolabz.bsky.social @parcc-inserm.bsky.social @upcite.bsky.social
lnkd.in/e5J92MWe
We developed a new adrenocortical cell model reproducing the major features of cells harboring a KCNJ5 mutation.
@aldolabz.bsky.social @parcc-inserm.bsky.social @upcite.bsky.social
Reposted by Thomas Uslar
Primary aldosteronism ist the most frequent cause of secondary hypertension in young adults aged 18-40 yrs! ahajrnls.org/4fLH1Uo
Prevalence and Risk Factors for Secondary Hypertension in Young Adults | Hypertension
BACKGROUND: The prevalence of secondary causes of hypertension in young adults is unknown, and
therefore, there is no consensus about the indication of screening of secondary hypertension
(2HTN) in th...
ahajrnls.org
November 26, 2024 at 9:51 PM
Primary aldosteronism ist the most frequent cause of secondary hypertension in young adults aged 18-40 yrs! ahajrnls.org/4fLH1Uo
Reposted by Thomas Uslar
Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al
EJE Vol 192, Issue 1, January 2025
Full paper 👉 doi.org/10.1093/ejen...
ESE Members via 👉 my.ese-hormones.org
EJE Vol 192, Issue 1, January 2025
Full paper 👉 doi.org/10.1093/ejen...
ESE Members via 👉 my.ese-hormones.org
February 16, 2025 at 11:06 AM
Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al
EJE Vol 192, Issue 1, January 2025
Full paper 👉 doi.org/10.1093/ejen...
ESE Members via 👉 my.ese-hormones.org
EJE Vol 192, Issue 1, January 2025
Full paper 👉 doi.org/10.1093/ejen...
ESE Members via 👉 my.ese-hormones.org
Reposted by Thomas Uslar
Subclinical primary aldosteronism + Natriuretic peptide deficiency => HYPERTENSION
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
March 14, 2025 at 6:11 PM
Subclinical primary aldosteronism + Natriuretic peptide deficiency => HYPERTENSION
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
Reposted by Thomas Uslar
Do patients want to be screened for primary aldosteronism: YES
How much PA can be identified with a direct-to-patient approach: A LOT
Can this approach be implemented nationwide: YES
@JeniferBrown
www.ahajournals.org/doi/10.1161/...
How much PA can be identified with a direct-to-patient approach: A LOT
Can this approach be implemented nationwide: YES
@JeniferBrown
www.ahajournals.org/doi/10.1161/...
March 20, 2025 at 11:21 PM
Do patients want to be screened for primary aldosteronism: YES
How much PA can be identified with a direct-to-patient approach: A LOT
Can this approach be implemented nationwide: YES
@JeniferBrown
www.ahajournals.org/doi/10.1161/...
How much PA can be identified with a direct-to-patient approach: A LOT
Can this approach be implemented nationwide: YES
@JeniferBrown
www.ahajournals.org/doi/10.1161/...
Reposted by Thomas Uslar
Work smarter, not harder!
A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.
Either way, aldosterone-directed therapy is very likely to provide major clinical benefits
www.ahajournals.org/eprint/TUS6C...
A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.
Either way, aldosterone-directed therapy is very likely to provide major clinical benefits
www.ahajournals.org/eprint/TUS6C...
April 3, 2025 at 1:09 AM
Work smarter, not harder!
A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.
Either way, aldosterone-directed therapy is very likely to provide major clinical benefits
www.ahajournals.org/eprint/TUS6C...
A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.
Either way, aldosterone-directed therapy is very likely to provide major clinical benefits
www.ahajournals.org/eprint/TUS6C...
Reposted by Thomas Uslar
The Primary Aldosteronism Medical Treatment Outcome (#PAMO) criteria represent an internationally developed outcome standard that can guide clinical practice and research into #primary #aldosteronism www.thelancet.com/journals/lan...
#FREE to read with registration (also FREE)
#MedSky #EndoSky
#FREE to read with registration (also FREE)
#MedSky #EndoSky
Outcomes after medical treatment for primary aldosteronism: an international consensus and analysis of treatment response in an international cohort
The Primary Aldosteronism Medical Treatment Outcome (PAMO) criteria represent an internationally
developed outcome standard that can guide clinical practice and research into primary
aldosteronism. Ef...
www.thelancet.com
March 16, 2025 at 12:35 PM
The Primary Aldosteronism Medical Treatment Outcome (#PAMO) criteria represent an internationally developed outcome standard that can guide clinical practice and research into #primary #aldosteronism www.thelancet.com/journals/lan...
#FREE to read with registration (also FREE)
#MedSky #EndoSky
#FREE to read with registration (also FREE)
#MedSky #EndoSky
Reposted by Thomas Uslar
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg thelancet.com/journals/lan...
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
Catecholamine-induced hypertensive crises: current insights and management
Phaeochromocytomas and paragangliomas (PPGLs) release catecholamines leading to catecholamine-induced
hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm
Hg. CIH crises ...
thelancet.com
March 18, 2025 at 3:43 PM
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg thelancet.com/journals/lan...
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
Reposted by Thomas Uslar
Due to the rarity of #adrenocortical #carcinoma, most of our knowledge comes from small, retrospective studies, which explains the limited progress in the comprehension of pathogenetic mechanisms, prognostication, and treatment www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky
#OpenAccess
#MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients
with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous
but frequently aggress...
www.thelancet.com
April 10, 2025 at 2:29 PM
Due to the rarity of #adrenocortical #carcinoma, most of our knowledge comes from small, retrospective studies, which explains the limited progress in the comprehension of pathogenetic mechanisms, prognostication, and treatment www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky
#OpenAccess
#MedSky #EndoSky #OncSky