Rossanese Lab
@temt-icr.bsky.social
Target Evaluation & Molecular Therapeutics lab at the Institute of Cancer Research, London. Unironically passionate about target validation 🎯 and drug discovery 💊 in oncology.
Reposted by Rossanese Lab
Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.
Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
July 1, 2025 at 5:48 AM
Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.
Reposted by Rossanese Lab
Reposted by Rossanese Lab
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
careers.dana-farber.org
June 30, 2025 at 7:30 PM
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
careers.dana-farber.org/job/11813/as...
Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
June 30, 2025 at 8:23 PM
Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Reposted by Rossanese Lab
11. The Authority Gap by Mary Ann Sieghart.
Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap
Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap
June 3, 2025 at 8:22 AM
11. The Authority Gap by Mary Ann Sieghart.
Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap
Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap
The timing on this is perfect 👌 as the #TEMTiversary merch arrived today! We are branded 🧬 💊!!
June 2, 2025 at 11:11 AM
The timing on this is perfect 👌 as the #TEMTiversary merch arrived today! We are branded 🧬 💊!!
Reposted by Rossanese Lab
Capivasertib given to breast cancer patients in Wales for first time
Capivasertib given to breast cancer patients in Wales for first time
Gwen Buchan, 62, says capivasertib will allow her to see her son's wedding and offers her "hope".
www.bbc.com
June 1, 2025 at 9:22 PM
Capivasertib given to breast cancer patients in Wales for first time
Decided to celebrate lab anniversary by reenergising our social media & sharing lab highlights every day in June…and forgot on the very 1st day 🫠
Anyway, it’s our 10th anniversary & we’ve got a new official (see bio) and unofficial logo 🎉; the latter has a story, b/c of course it does… #TEMTiversary
Anyway, it’s our 10th anniversary & we’ve got a new official (see bio) and unofficial logo 🎉; the latter has a story, b/c of course it does… #TEMTiversary
June 2, 2025 at 8:38 AM
Decided to celebrate lab anniversary by reenergising our social media & sharing lab highlights every day in June…and forgot on the very 1st day 🫠
Anyway, it’s our 10th anniversary & we’ve got a new official (see bio) and unofficial logo 🎉; the latter has a story, b/c of course it does… #TEMTiversary
Anyway, it’s our 10th anniversary & we’ve got a new official (see bio) and unofficial logo 🎉; the latter has a story, b/c of course it does… #TEMTiversary
Reposted by Rossanese Lab
Happy #InternationalClinicalTrialsDay! 🎉
At DDU-IIT @icr.ac.uk , we’re proud to help turn cutting-edge science into real-world impact. 🔬🌍
To the patients, families & teams behind every trial—your courage fuels the future of medicine. ❤️🔥
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP
At DDU-IIT @icr.ac.uk , we’re proud to help turn cutting-edge science into real-world impact. 🔬🌍
To the patients, families & teams behind every trial—your courage fuels the future of medicine. ❤️🔥
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP
May 20, 2025 at 9:20 AM
Happy #InternationalClinicalTrialsDay! 🎉
At DDU-IIT @icr.ac.uk , we’re proud to help turn cutting-edge science into real-world impact. 🔬🌍
To the patients, families & teams behind every trial—your courage fuels the future of medicine. ❤️🔥
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP
At DDU-IIT @icr.ac.uk , we’re proud to help turn cutting-edge science into real-world impact. 🔬🌍
To the patients, families & teams behind every trial—your courage fuels the future of medicine. ❤️🔥
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP
In June, we are having 5-yr external scientific review & the lab celebrates 10-yr anniversary 🎉! Both good things, but prep has me reflecting…a lot. My time at the ICR is almost perfectly bisected by the pandemic & the two halves feel like different life times. Literally The Before Times™️ & After.
May 21, 2025 at 6:34 AM
In June, we are having 5-yr external scientific review & the lab celebrates 10-yr anniversary 🎉! Both good things, but prep has me reflecting…a lot. My time at the ICR is almost perfectly bisected by the pandemic & the two halves feel like different life times. Literally The Before Times™️ & After.
Reposted by Rossanese Lab
A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
How advances in technology are speeding up the discovery of new cancer drugs
How advances in technology are speeding up the discovery of new cancer drugs
www.icr.ac.uk
May 2, 2025 at 8:51 AM
A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
Reposted by Rossanese Lab
Get up to speed with the cancer dormancy field.
Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.
#AACR2025 | @icr.ac.uk
Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.
#AACR2025 | @icr.ac.uk
April 26, 2025 at 3:01 PM
Get up to speed with the cancer dormancy field.
Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.
#AACR2025 | @icr.ac.uk
Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.
#AACR2025 | @icr.ac.uk
Reposted by Rossanese Lab
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function - Nature Communications
A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used...
doi.org
March 20, 2025 at 6:57 AM
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Rossanese Lab
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
Nobel prize-winning technology in cancer care - The Cancer Researcher
Katalin Karikó's work into mRNA vaccines
magazine.eacr.org
March 19, 2025 at 7:43 AM
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
Reposted by Rossanese Lab
💡 Thinking about a PhD?
✨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now 👉 humantechnopole.it/en/trainings... #phdlife
✨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now 👉 humantechnopole.it/en/trainings... #phdlife
March 19, 2025 at 9:32 AM
💡 Thinking about a PhD?
✨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now 👉 humantechnopole.it/en/trainings... #phdlife
✨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now 👉 humantechnopole.it/en/trainings... #phdlife
Reposted by Rossanese Lab
🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
March 18, 2025 at 12:46 PM
🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Reposted by Rossanese Lab
📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀
🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities
📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...
🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities
📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...
March 17, 2025 at 12:07 PM
📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀
🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities
📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...
🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities
📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...
Reposted by Rossanese Lab
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
January 31, 2025 at 11:54 AM
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
March 18, 2025 at 12:46 PM
🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
Reposted by Rossanese Lab
We were delighted to host Shadow Secretary of State for Science, Innovation & Technology, Alan Mak MP at our Chester Beatty Labs last week 👋
We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology 🧵
#CancerResearch
We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology 🧵
#CancerResearch
March 14, 2025 at 1:36 PM
We were delighted to host Shadow Secretary of State for Science, Innovation & Technology, Alan Mak MP at our Chester Beatty Labs last week 👋
We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology 🧵
#CancerResearch
We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology 🧵
#CancerResearch
Happy Pi Day ! Our lab has a long and frankly sit-com quality relationship with Pi Day due to the inevitable date confusion when I moved to the UK 🇬🇧. Yes, we also celebrate on 22 July as the closest fractional approximation of pi, why do you ask?
View from lab meeting this morning 🥧 ☕️ 📊
View from lab meeting this morning 🥧 ☕️ 📊
March 14, 2025 at 1:44 PM
Happy Pi Day ! Our lab has a long and frankly sit-com quality relationship with Pi Day due to the inevitable date confusion when I moved to the UK 🇬🇧. Yes, we also celebrate on 22 July as the closest fractional approximation of pi, why do you ask?
View from lab meeting this morning 🥧 ☕️ 📊
View from lab meeting this morning 🥧 ☕️ 📊
Reposted by Rossanese Lab
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
March 5, 2025 at 2:44 PM
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
Reposted by Rossanese Lab
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader
Pfizer and Arvinas’ estrogen receptor (ER) degrader has
www.fiercebiotech.com
March 12, 2025 at 6:44 AM
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
Reposted by Rossanese Lab
🎉 What an exciting day! For a whole day, the children of HT employees became little scientists and learned so much about lab safety, blood and the immune system, water and more.
🔭 The future of science is in their hands!
🔭 The future of science is in their hands!
March 12, 2025 at 8:37 AM
🎉 What an exciting day! For a whole day, the children of HT employees became little scientists and learned so much about lab safety, blood and the immune system, water and more.
🔭 The future of science is in their hands!
🔭 The future of science is in their hands!
Reposted by Rossanese Lab
The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows
March 10, 2025 at 2:09 PM
The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows