Rob van Montfort
@robvanmontfort.bsky.social
Structural biologist at ICR London focused on cancer drug discovery. Views my own.
In a couple of weeks Sonja and I are back in the beautiful Lake District for The Climb of Life, as we raise vital funds for the cancer research of the Institute of Cancer Research (@icr.ac.uk).If you would lke to supoort us, you can do so via this link. www.justgiving.com/page/sonja-r...
The Climb of Life 2025
Help Sonja - Rob van Montfort raise money to support The Institute of Cancer Research (ICR)
www.justgiving.com
October 21, 2025 at 9:15 PM
In a couple of weeks Sonja and I are back in the beautiful Lake District for The Climb of Life, as we raise vital funds for the cancer research of the Institute of Cancer Research (@icr.ac.uk).If you would lke to supoort us, you can do so via this link. www.justgiving.com/page/sonja-r...
Applications for PhD studentships @icr.ac.uk are now open. Are you interested in a PhD in structural biology applied to proteins involved in cancer? Check out the PhD-project available in my group. You can apply via the ICR website. Closing date is 16 November 2016.
www.icr.ac.uk/study-and-ca...
www.icr.ac.uk/study-and-ca...
Elucidation of the molecular basis for the chaperoning of DEAH-box RNA helicases by the oncoprotein and cochaperone NudCD1
Elucidation of the molecular basis for the chaperoning of DEAH-box RNA helicases by the oncoprotein and cochaperone NudCD1
www.icr.ac.uk
October 17, 2025 at 3:33 PM
Applications for PhD studentships @icr.ac.uk are now open. Are you interested in a PhD in structural biology applied to proteins involved in cancer? Check out the PhD-project available in my group. You can apply via the ICR website. Closing date is 16 November 2016.
www.icr.ac.uk/study-and-ca...
www.icr.ac.uk/study-and-ca...
Thank you for a great day with us @icr.ac.uk and wonderful drug discovery talk @hartungingo.bsky.social!
Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
June 30, 2025 at 8:50 PM
Thank you for a great day with us @icr.ac.uk and wonderful drug discovery talk @hartungingo.bsky.social!
Reposted by Rob van Montfort
🌟🌟🌟 Join our cancer drug discovery team in London-Sutton! 🌟🌟🌟
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR
ICR Centre for Protein Degradation on LinkedIn: Higher Scientific Officer - Drug Discovery Biology, Centre for Protein…
🤝 Are you passionate about Targeted Protein Degradation and want to join us on our mission to make the discoveries that defeat cancer?
Dr Agnieszka…
www.linkedin.com
May 13, 2025 at 9:04 PM
A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
How advances in technology are speeding up the discovery of new cancer drugs
How advances in technology are speeding up the discovery of new cancer drugs
www.icr.ac.uk
May 2, 2025 at 8:51 AM
A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
Reposted by Rob van Montfort
NEWS: NICE has recommended capivasertib for advanced #BreastCancer.
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
April 11, 2025 at 6:37 AM
NEWS: NICE has recommended capivasertib for advanced #BreastCancer.
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.
Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.
Bauke W. Dijkstra et al.: Jan Drenth (1925–2025) @univgroningen...##IUCrhttps://journals.iucr.org/paper?S205979832500275X
Jan Drenth (1925–2025)
Jan Drenth is remembered.
journals.iucr.org
March 29, 2025 at 5:53 PM
Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.
The Centre for Cancer Drug Discovery @icr.ac.uk looking fantastic in today's evening sun
March 20, 2025 at 11:04 PM
The Centre for Cancer Drug Discovery @icr.ac.uk looking fantastic in today's evening sun
Reposted by Rob van Montfort
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function - Nature Communications
A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used...
doi.org
March 20, 2025 at 6:57 AM
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Rob van Montfort
Today is #InternationalWomensDay 👏
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
March 8, 2025 at 10:26 AM
Today is #InternationalWomensDay 👏
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
Reposted by Rob van Montfort
Today Jan Drenth would have been 100 years, but sadly he passed away last week.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
February 20, 2025 at 12:58 PM
Today Jan Drenth would have been 100 years, but sadly he passed away last week.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
Reposted by Rob van Montfort
It's #InternationalMotherLanguageDay 🌍
We're proud of our diverse community who are dedicated to defeating cancer.
Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️
We're proud of our diverse community who are dedicated to defeating cancer.
Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️
February 21, 2025 at 1:40 PM
It's #InternationalMotherLanguageDay 🌍
We're proud of our diverse community who are dedicated to defeating cancer.
Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️
We're proud of our diverse community who are dedicated to defeating cancer.
Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️
We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
Higher Scientific Officer - Protein production, purification and assay specialist in Sutton | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer - Protein production, purification and assay specialist vacancy in Sutton.
Salary : Commencement on the salary range is subject ...
jobs.icr.ac.uk
February 21, 2025 at 9:22 AM
We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
Postdoctoral Training Fellow – X-Ray Crystallography in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow – X-Ray Crystallography vacancy in Sutton.
Salary: Dependent on relevant Postdoctoral experience. Future progression is base...
jobs.icr.ac.uk
February 21, 2025 at 9:12 AM
Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
Reposted by Rob van Montfort
📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother.
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
British professor makes ‘thrilling’ breakthrough for cancer that killed his mother
Paul Workman has researched untreatable chordoma for years. Now new technology points towards to a potential drug to beat it
www.theguardian.com
February 15, 2025 at 5:38 PM
📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother.
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
Reposted by Rob van Montfort
Now over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...
February 12, 2025 at 8:30 PM
Now over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...
Reposted by Rob van Montfort
On International Day of Women and Girls in Science, we're celebrating our awe-inspiring women helping to defeat cancer 👩🔬👏
Hear from Professor Ros Eeles, Professor Helen McNair
(The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️
#WomenInScience
Hear from Professor Ros Eeles, Professor Helen McNair
(The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️
#WomenInScience
February 11, 2025 at 9:15 AM
On International Day of Women and Girls in Science, we're celebrating our awe-inspiring women helping to defeat cancer 👩🔬👏
Hear from Professor Ros Eeles, Professor Helen McNair
(The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️
#WomenInScience
Hear from Professor Ros Eeles, Professor Helen McNair
(The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️
#WomenInScience
Reposted by Rob van Montfort
We’re delighted that The Scottish Medicines Consortium (SMC) has today recommended olaparib for use in advanced #BreastCancer.
The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes.
scottishmedicines.org.uk/about-us/lat...
The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes.
scottishmedicines.org.uk/about-us/lat...
February 2025 decisions news release
scottishmedicines.org.uk
February 10, 2025 at 2:41 PM
We’re delighted that The Scottish Medicines Consortium (SMC) has today recommended olaparib for use in advanced #BreastCancer.
The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes.
scottishmedicines.org.uk/about-us/lat...
The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes.
scottishmedicines.org.uk/about-us/lat...
Reposted by Rob van Montfort
Will these tools further exacerbate biases in the literature: if the opinion of those who write many papers gets fed into their training more than the opinion of those who write sparingly?
Scientists should use their precious time to do good science, not to write many papers...
Scientists should use their precious time to do good science, not to write many papers...
Many scientists who have tried OpenAI's 'deep research' tool are impressed with its ability to write literature reviews or full review papers and even identify gaps in knowledge. But others are less enthusiastic.
https://go.nature.com/4gu9uOo
https://go.nature.com/4gu9uOo
OpenAI’s ‘deep research’ tool: is it useful for scientists?
The model produces cited, pages-long reports that might be helpful for generating literature reviews.
go.nature.com
February 7, 2025 at 7:50 AM
Will these tools further exacerbate biases in the literature: if the opinion of those who write many papers gets fed into their training more than the opinion of those who write sparingly?
Scientists should use their precious time to do good science, not to write many papers...
Scientists should use their precious time to do good science, not to write many papers...
Reposted by Rob van Montfort
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.
Same link, new title and some updates.
Same link, new title and some updates.
Revised and Extended: What's Happening Inside the NIH and NSF
www.science.org
February 5, 2025 at 5:17 PM
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.
Same link, new title and some updates.
Same link, new title and some updates.
Reposted by Rob van Montfort
ICYMI
The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug.
So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.
The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug.
So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.
Drug breakthrough offers hope for advanced prostate cancer patients
Research suggests a new drug slowed the growth of prostate cancer cells, including those with a resistance to the hormone therapy enzalutamide.
buff.ly
January 27, 2025 at 7:55 AM
ICYMI
The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug.
So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.
The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug.
So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
January 31, 2025 at 11:54 AM
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
We have a vacancy in assay development, compound profiling, and screening to help progress the cancer drug discovery projects of the Centre for Cancer Drug Discovery @icrlondon.bsky.social. If you are interested please check out the details below.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
Higher Scientific Officer - Assay development and compound profiling in Sutton | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer - Assay development and compound profiling vacancy in Sutton.
Salary : Commencement on the salary range is subject to comparable skil...
jobs.icr.ac.uk
January 23, 2025 at 4:07 PM
We have a vacancy in assay development, compound profiling, and screening to help progress the cancer drug discovery projects of the Centre for Cancer Drug Discovery @icrlondon.bsky.social. If you are interested please check out the details below.
jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk/vacancies/11...
If you are interested in a PhD studentship in chemical biology linked to brain cancer in children, check out the position Gary Newton and myself have available. @icrlondon.bsky.social. www.icr.ac.uk/study-and-ca...
Targeting SRC in G4-Medulloblastoma
OPEN: Targeting SRC in G4-Medulloblastoma
www.icr.ac.uk
January 22, 2025 at 4:52 PM
If you are interested in a PhD studentship in chemical biology linked to brain cancer in children, check out the position Gary Newton and myself have available. @icrlondon.bsky.social. www.icr.ac.uk/study-and-ca...
Beautiful and frosty morning @icrlondon.bsky.social today.
January 3, 2025 at 2:08 PM
Beautiful and frosty morning @icrlondon.bsky.social today.