Thomas B. Poulsen
@tbpoulsen.bsky.social
Professor at Aarhus University. Total synthesis of natural products. Covalent chemical biology.
Co-founder: Mmimetika Biosciences and Kripthonite Therapeutics
Co-founder: Mmimetika Biosciences and Kripthonite Therapeutics
Reposted by Thomas B. Poulsen
Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social and @oliverthornseshold.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
August 29, 2025 at 6:56 AM
Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social and @oliverthornseshold.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Thomas B. Poulsen
Great to see Ivan and Charlie's work on the synthesis and reactivity of vinyl sulfonimidamides out in @chemicalscience.rsc.org Here they show that reactivity either above or below that of the corresponding acrylamide can be achieved. @oxfordchemistry.bsky.social
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Synthesis and functionalization of vinyl sulfonimidamides and their potential as electrophilic warheads
Covalent inhibitor design is dominated by the use of electrophilic acrylamide warheads. One limitation of acrylamides is that there are limited opportunities to modify their electrophilicity, and henc...
pubs.rsc.org
June 17, 2025 at 6:08 AM
Great to see Ivan and Charlie's work on the synthesis and reactivity of vinyl sulfonimidamides out in @chemicalscience.rsc.org Here they show that reactivity either above or below that of the corresponding acrylamide can be achieved. @oxfordchemistry.bsky.social
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Thomas B. Poulsen
Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25
June 13, 2025 at 9:04 AM
Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25
Delighted to share our newest pre-print. Here, we describe a very short synthesis (11 steps, LLS) of the polyether antibiotic lasalocid acid A.
doi.org/10.26434/che...
doi.org/10.26434/che...
May 29, 2025 at 11:44 AM
Delighted to share our newest pre-print. Here, we describe a very short synthesis (11 steps, LLS) of the polyether antibiotic lasalocid acid A.
doi.org/10.26434/che...
doi.org/10.26434/che...
Reposted by Thomas B. Poulsen
18 days left until the #NordicRetrosynthesisChallenge begins...
Is your team ready?
Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com
Sponsored by Carbolution Chemicals GmbH and AstraZeneca
Please share! #chemsky #Chembio
Is your team ready?
Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com
Sponsored by Carbolution Chemicals GmbH and AstraZeneca
Please share! #chemsky #Chembio
April 17, 2025 at 7:51 AM
18 days left until the #NordicRetrosynthesisChallenge begins...
Is your team ready?
Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com
Sponsored by Carbolution Chemicals GmbH and AstraZeneca
Please share! #chemsky #Chembio
Is your team ready?
Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com
Sponsored by Carbolution Chemicals GmbH and AstraZeneca
Please share! #chemsky #Chembio
Reposted by Thomas B. Poulsen
45 days left until the challenge is revealed... Are you familiar with the rules? Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share ! #chemsky #Chembio
Please share ! #chemsky #Chembio
March 21, 2025 at 10:54 AM
45 days left until the challenge is revealed... Are you familiar with the rules? Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share ! #chemsky #Chembio
Please share ! #chemsky #Chembio
Reposted by Thomas B. Poulsen
66 days left until the challenge is revealed... Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
Please share and spread the news! #chemsky #Chembio
February 28, 2025 at 8:07 AM
66 days left until the challenge is revealed... Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
Please share and spread the news! #chemsky #Chembio
Reposted by Thomas B. Poulsen
Do you already have a team to participate in the #NordicRetrosynthesisChallenge on 5th of May 2025?
For more info check nordicretrosynthesischallenge.com!
Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
For more info check nordicretrosynthesischallenge.com!
Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
February 7, 2025 at 12:05 PM
Do you already have a team to participate in the #NordicRetrosynthesisChallenge on 5th of May 2025?
For more info check nordicretrosynthesischallenge.com!
Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
For more info check nordicretrosynthesischallenge.com!
Sponsored by Carbolution Chemicals and AstraZeneca
Please share and spread the news! #chemsky #Chembio
Check out the summary of the newest paper from our lab. Just out in Chemical Science #chembio #chemicalbiology
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
January 30, 2025 at 9:42 PM
Check out the summary of the newest paper from our lab. Just out in Chemical Science #chembio #chemicalbiology
Reposted by Thomas B. Poulsen
Ten simple rules for developing good reading habits during graduate school and beyond
To me, the most important are:
Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)
To me, the most important are:
Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)
January 26, 2025 at 10:15 AM
Ten simple rules for developing good reading habits during graduate school and beyond
To me, the most important are:
Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)
To me, the most important are:
Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)
Here is a very interesting new paper from the Baker and Chudasama groups at University College London. A clever example of leveraging reversible disulfide rebridging chemistry to achieve selective lysine modification (via proximity) of antibody-fragments.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Formation of mono- and dual-labelled antibody fragment conjugates via reversible site-selective disulfide modification and proximity induced lysine reactivity
Many protein bioconjugation strategies focus on the modification of lysine residues owing to the nucleophilicity of their amine side-chain, the generally high abundance of lysine residues on a protein...
pubs.rsc.org
January 9, 2025 at 5:25 PM
Here is a very interesting new paper from the Baker and Chudasama groups at University College London. A clever example of leveraging reversible disulfide rebridging chemistry to achieve selective lysine modification (via proximity) of antibody-fragments.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Thomas B. Poulsen
It is great to have @aekiib.bsky.social from the group of @tbpoulsen.bsky.social as visiting PhD student in the lab. His stay in our lab allows us to exchange a lot of thoughts and technologies between the labs and learn so much from each other. #ChemBio onlinelibrary.wiley....
November 26, 2024 at 4:02 PM
It is great to have @aekiib.bsky.social from the group of @tbpoulsen.bsky.social as visiting PhD student in the lab. His stay in our lab allows us to exchange a lot of thoughts and technologies between the labs and learn so much from each other. #ChemBio onlinelibrary.wiley....
Reposted by Thomas B. Poulsen
Now that’s a good #ChemSky thread!
Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻
Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
November 20, 2024 at 9:47 PM
Now that’s a good #ChemSky thread!
Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻
Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻
Reposted by Thomas B. Poulsen
This looks like an interesting application of the oxSTEF probes developed in the Poulsen lab before. Good example of developing interesting chemistry/chemical biology and then asking the right biological questions.
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
November 20, 2024 at 7:12 PM
This looks like an interesting application of the oxSTEF probes developed in the Poulsen lab before. Good example of developing interesting chemistry/chemical biology and then asking the right biological questions.
Reposted by Thomas B. Poulsen
Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...
Chemoproteomic mapping of the N-terminal cysteinome
The oxidation status of N-terminal cysteines directly dictates protein stability via arginylation and proteasomal degradation. However, only a handful of proteins have been shown to be regulated via t...
doi.org
November 21, 2024 at 9:23 AM
Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...
Reposted by Thomas B. Poulsen
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
November 21, 2024 at 9:28 AM
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
Interested in covalent probes? Check out our most recent pre-print on chemoproteomic profiling of N-terminal cysteines. Nice overview/summary from lead author @esbensv.bsky.social
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
November 20, 2024 at 4:00 PM
Interested in covalent probes? Check out our most recent pre-print on chemoproteomic profiling of N-terminal cysteines. Nice overview/summary from lead author @esbensv.bsky.social
Reposted by Thomas B. Poulsen
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
November 17, 2024 at 10:58 PM
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
Reposted by Thomas B. Poulsen
Looking back on the Acetonitrile Olympics. You remember those, right?
The Acetonitrile Olympics
www.science.org
August 7, 2024 at 12:49 PM
Looking back on the Acetonitrile Olympics. You remember those, right?
Reposted by Thomas B. Poulsen
Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections https://covalentmodifiers.blogspot.com/2024/02/development-of-oxadiazolone-activity.html
February 28, 2024 at 8:00 AM
Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections https://covalentmodifiers.blogspot.com/2024/02/development-of-oxadiazolone-activity.html
Reposted by Thomas B. Poulsen
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality https://covalentmodifiers.blogspot.com/2024/02/molecular-bidents-with-two.html
February 29, 2024 at 6:00 PM
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality https://covalentmodifiers.blogspot.com/2024/02/molecular-bidents-with-two.html
Reposted by Thomas B. Poulsen
Dear colleagues, my temporary contract here at the MPI is ending this year, and for reasons of german work regulations (Wissenschaftszeitvertragsgesetz, a german word of typical length ;-) ), it can not be extended. So I am looking for new opportunities, preferably in Germany.
February 4, 2024 at 7:08 PM
Dear colleagues, my temporary contract here at the MPI is ending this year, and for reasons of german work regulations (Wissenschaftszeitvertragsgesetz, a german word of typical length ;-) ), it can not be extended. So I am looking for new opportunities, preferably in Germany.
Reposted by Thomas B. Poulsen
Job Alert - Our team @uni-jena.de is looking for a PhD student who wants to unravel how enzymatic modifications of natural products impact microbial interactions. This is a highly interdisciplinary project with great collaborations within the CRC1127 ChemBioSys! Apply here until Feb.04: t.ly/alya1
January 5, 2024 at 2:22 PM
Job Alert - Our team @uni-jena.de is looking for a PhD student who wants to unravel how enzymatic modifications of natural products impact microbial interactions. This is a highly interdisciplinary project with great collaborations within the CRC1127 ChemBioSys! Apply here until Feb.04: t.ly/alya1