Thomas B. Poulsen
@tbpoulsen.bsky.social
Professor at Aarhus University. Total synthesis of natural products. Covalent chemical biology.
Co-founder: Mmimetika Biosciences and Kripthonite Therapeutics
Co-founder: Mmimetika Biosciences and Kripthonite Therapeutics
Congrats to all of the authors, in particular to Florian Kromm and Søren Borcher Møller who lead this work together. 👏 We are grateful for the @erc.europa.eu opa.eu for funding.
#totalsynthesis
#totalsynthesis
May 29, 2025 at 11:44 AM
Congrats to all of the authors, in particular to Florian Kromm and Søren Borcher Møller who lead this work together. 👏 We are grateful for the @erc.europa.eu opa.eu for funding.
#totalsynthesis
#totalsynthesis
Our new route represents a dramatic shortening compared to classic routes to this compound, which was strongly enabled by development of a new transformation to directly couple the challenging attached oxacyclic rings. We are further excited about the generality of this C(sp3)-C(sp3) coupling method
May 29, 2025 at 11:44 AM
Our new route represents a dramatic shortening compared to classic routes to this compound, which was strongly enabled by development of a new transformation to directly couple the challenging attached oxacyclic rings. We are further excited about the generality of this C(sp3)-C(sp3) coupling method
Enjoy the meeting Stephan. Unfortunately, I cannot attend this one but hopefully the tradition continues.
March 27, 2025 at 11:02 PM
Enjoy the meeting Stephan. Unfortunately, I cannot attend this one but hopefully the tradition continues.
Big Congrats Luca!
January 9, 2025 at 8:16 PM
Big Congrats Luca!
Cool picture! Very happy about this exchange - Thanks for hosting. So many interesting experiments and data already.
November 26, 2024 at 4:11 PM
Cool picture! Very happy about this exchange - Thanks for hosting. So many interesting experiments and data already.
Reposted by Thomas B. Poulsen
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
November 21, 2024 at 9:28 AM
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...