Hymeglusin (1) is a fungal polyketide consisting of a β-lactone ring with a unique (3R,4R) configuration. 1 is a potent 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase inhibitor. Because it circumve...

Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

A strategy is introduced that infers whole-animal metabolic flux wiring from transcriptional phenotypes in the nematode Caenorhabditis elegans and several features in its adult metabolism are discovered that are validated by stable isotope tracing.

Insights from probing the shock-absorbing layer within the crustacean’s club-like claw could inspire the design of tough new materials.

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

Burkholderiales bacteria have emerged as a promising source of structurally diverse natural products that are expected to play important ecological and industrial roles. This order ranks in the top th...

Zhaonella formicivorans produces methanol, for a novel syntrophic interaction, without requiring methylated compounds as an input.

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.

A cross-sectional study from four African countries shows the importance of investigating the gut microbiome in previously under-represented populations and provides a framework for equitable microbiome research.

Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ATT2, by enabling the fine-tuning of gibberellins, is expected to be a potential new post-Green Revolution gene.