Slim Mzoughi
@sleemmz.bsky.social
Assistant Professor, Tish Cancer Institute @Mount Sinai. Colorectal Cancer. Oncofetal reprogramming. Views are my own. "By land and by sea, Carthage will rise again"
https://profiles.mountsinai.org/slim-mzoughi
https://profiles.mountsinai.org/slim-mzoughi
Pinned
Slim Mzoughi
@sleemmz.bsky.social
· Feb 10
Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵
I have two open positions (wet and dry lab) to work on phenotypic plasticity and therapy resistance. Come join a vibrant team in a vibrant city!
Are you passionate about phenotypic plasticity and therapy resistance? | Slim Mzoughi
Are you passionate about phenotypic plasticity and therapy resistance?
Curious about the epigenetic mechanisms driving these processes?
Excited to make transformative discoveries and take your career ...
www.linkedin.com
July 1, 2025 at 3:48 PM
I have two open positions (wet and dry lab) to work on phenotypic plasticity and therapy resistance. Come join a vibrant team in a vibrant city!
📢 Exciting news: The Mzoughi Lab will launch in January 2026 at the Icahn School of Medicine at Mount Sinai in NYC! Young talents and cell plasticity enthusiasts—stay tuned for upcoming opportunities!
June 25, 2025 at 12:50 PM
📢 Exciting news: The Mzoughi Lab will launch in January 2026 at the Icahn School of Medicine at Mount Sinai in NYC! Young talents and cell plasticity enthusiasts—stay tuned for upcoming opportunities!
🔈We've got the cover of the 2nd NG issue for 2025🙌
Read about the cover: In the comment👇
Also check out our research briefing🚨 (link below):
nature.com/articles/s41...
nature.com/articles/s41...
Read about the cover: In the comment👇
Also check out our research briefing🚨 (link below):
nature.com/articles/s41...
nature.com/articles/s41...
February 12, 2025 at 6:27 PM
🔈We've got the cover of the 2nd NG issue for 2025🙌
Read about the cover: In the comment👇
Also check out our research briefing🚨 (link below):
nature.com/articles/s41...
nature.com/articles/s41...
Read about the cover: In the comment👇
Also check out our research briefing🚨 (link below):
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Slim Mzoughi
Reposted by Slim Mzoughi
📢ONLINE @naturegenet.bsky.social
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 11, 2025 at 7:56 AM
📢ONLINE @naturegenet.bsky.social
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Slim Mzoughi
Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 11, 2025 at 9:01 AM
Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Slim Mzoughi
So happy to see this live, Slim! Congratulations to you, Ernesto and the whole team for your resilience, vision and creativity!
Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵
February 10, 2025 at 3:31 PM
So happy to see this live, Slim! Congratulations to you, Ernesto and the whole team for your resilience, vision and creativity!
Reposted by Slim Mzoughi
Out now @naturegenet.bsky.social:
**Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer**
www.nature.com/articles/s41...
Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer.
#science
#epigenetics
#OncoSky
**Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer**
www.nature.com/articles/s41...
Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer.
#science
#epigenetics
#OncoSky
February 10, 2025 at 1:12 PM
Out now @naturegenet.bsky.social:
**Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer**
www.nature.com/articles/s41...
Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer.
#science
#epigenetics
#OncoSky
**Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer**
www.nature.com/articles/s41...
Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer.
#science
#epigenetics
#OncoSky
Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵
February 10, 2025 at 3:06 PM
Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵
Reposted by Slim Mzoughi
The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪
Cellular atlases are unlocking the mysteries of the human body
Scientists reflect on insights from the Human Cell Atlas.
go.nature.com
November 26, 2024 at 3:06 PM
The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪
Reposted by Slim Mzoughi
A shared meal, a kiss on the cheek: these social acts bring people together — and bring their microbiomes together, too. …. It is fascinating how our microbiome is shaped! www.nature.com/articles/d41...
Your friends shape your microbiome — and so do their friends
Analysis of nearly 2,000 people living in remote villages in Honduras reveals who’s spreading gut microorganisms to whom.
www.nature.com
November 23, 2024 at 12:53 PM
A shared meal, a kiss on the cheek: these social acts bring people together — and bring their microbiomes together, too. …. It is fascinating how our microbiome is shaped! www.nature.com/articles/d41...
November 23, 2024 at 7:45 PM
Happy with the move to🦋 ! I hope we can use this platform as a fresh start to foster meaningful scientific discussions and collegiality, rather than superficial praise or unproductive disagreements.
November 20, 2024 at 5:42 PM
Happy with the move to🦋 ! I hope we can use this platform as a fresh start to foster meaningful scientific discussions and collegiality, rather than superficial praise or unproductive disagreements.