Simone Minnie
@simone-minnie.bsky.social
Assistant Professor @ UCSF| Myeloma, BMT, Immunotherapy Research
Reposted by Simone Minnie
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...
www.biorxiv.org
August 14, 2025 at 5:30 PM
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
Now that the lab has stuff in it, I’m looking for a postdoc.
Must have:
- Mouse experience (several years ideally)
- Cell culture experience
- An interest in T cells
- Team player
Bonus points for:
- any flow experience
- any scRNAseq exp (wet or dry)
- CAR T manufacturing
Must have:
- Mouse experience (several years ideally)
- Cell culture experience
- An interest in T cells
- Team player
Bonus points for:
- any flow experience
- any scRNAseq exp (wet or dry)
- CAR T manufacturing
July 1, 2025 at 10:47 PM
Now that the lab has stuff in it, I’m looking for a postdoc.
Must have:
- Mouse experience (several years ideally)
- Cell culture experience
- An interest in T cells
- Team player
Bonus points for:
- any flow experience
- any scRNAseq exp (wet or dry)
- CAR T manufacturing
Must have:
- Mouse experience (several years ideally)
- Cell culture experience
- An interest in T cells
- Team player
Bonus points for:
- any flow experience
- any scRNAseq exp (wet or dry)
- CAR T manufacturing
Seeing my colleagues succeed brings me so much joy. Can’t wait for the ‘proud PI’ moments to come from my lab. I’ve already asked my trainees how they like to receive recognition and they are both the quiet email types. This will be a challenge…gotta rein it in!
June 17, 2025 at 4:35 AM
Seeing my colleagues succeed brings me so much joy. Can’t wait for the ‘proud PI’ moments to come from my lab. I’ve already asked my trainees how they like to receive recognition and they are both the quiet email types. This will be a challenge…gotta rein it in!
Reposted by Simone Minnie
Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation | Journal of Clinical Oncology ascopubs.org/doi/10.1200/...
Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
PURPOSEAllogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment
for advanced hematologic malignancies. HSCT using human leukocyte antigen (HLA)-mismatched
donors is historical...
ascopubs.org
June 16, 2025 at 9:10 PM
Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation | Journal of Clinical Oncology ascopubs.org/doi/10.1200/...
The best advice I received about hiring was always hire people smarter than yourself. I’ve taken that very seriously, plus added my own criteria “vibes”, and I am so excited for the new Minnie Lab team members to start soon!!
June 11, 2025 at 2:02 AM
The best advice I received about hiring was always hire people smarter than yourself. I’ve taken that very seriously, plus added my own criteria “vibes”, and I am so excited for the new Minnie Lab team members to start soon!!
Reposted by Simone Minnie
Reminder:
Not everything thought needs to be said
Not everything said needs to be written
Not everything written needs to go on social media
Not everything thought needs to be said
Not everything said needs to be written
Not everything written needs to go on social media
June 8, 2025 at 5:38 AM
Reminder:
Not everything thought needs to be said
Not everything said needs to be written
Not everything written needs to go on social media
Not everything thought needs to be said
Not everything said needs to be written
Not everything written needs to go on social media
Reposted by Simone Minnie
The astounding contribution of US academic science to new medicines
www.statnews.com/2025/06/06/u...
www.statnews.com/2025/06/06/u...
We set out to quantify U.S. academic contributions to medicines. The results stunned even us
From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.
www.statnews.com
June 7, 2025 at 6:04 PM
The astounding contribution of US academic science to new medicines
www.statnews.com/2025/06/06/u...
www.statnews.com/2025/06/06/u...
Reposted by Simone Minnie
How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 7, 2025 at 2:41 PM
How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested!
aprecruit.ucsf.edu/JPF05438
aprecruit.ucsf.edu/JPF05438
Minnie Lab - Junior, Assistant, or Associate Specialist
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
April 17, 2025 at 4:15 PM
I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested!
aprecruit.ucsf.edu/JPF05438
aprecruit.ucsf.edu/JPF05438
Hiring freeze at the same time as starting a lab will keep things interesting. Got one hire through the door before it happened at least. This tech really wanted some hands-on training and boy are they going to get it 😂
March 27, 2025 at 11:25 PM
Hiring freeze at the same time as starting a lab will keep things interesting. Got one hire through the door before it happened at least. This tech really wanted some hands-on training and boy are they going to get it 😂
Reposted by Simone Minnie
Fred Hutch at #Tandem25: Catch presentations from Drs.
Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L
Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L
February 13, 2025 at 8:00 PM
Fred Hutch at #Tandem25: Catch presentations from Drs.
Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L
Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L
I am beyond excited to be starting my lab at UCSF in May 2025. I'll be joining the Hematology/Oncology Division and working with the Myeloma Program (lead by @ajaichari.bsky.social) to advance immunotherapies and cellular therapies for myeloma!
January 17, 2025 at 9:52 PM
I am beyond excited to be starting my lab at UCSF in May 2025. I'll be joining the Hematology/Oncology Division and working with the Myeloma Program (lead by @ajaichari.bsky.social) to advance immunotherapies and cellular therapies for myeloma!
Happy New Year! 2025 is going to be a big one!!
January 1, 2025 at 11:17 PM
Happy New Year! 2025 is going to be a big one!!
Reposted by Simone Minnie
Hematologists please follow Ajai Chari, the very talented leader of the @ucsfcancer.bsky.social #myeloma program. #hematology
bsky.app/profile/ajai...
bsky.app/profile/ajai...
bsky.app
December 19, 2024 at 1:59 AM
Hematologists please follow Ajai Chari, the very talented leader of the @ucsfcancer.bsky.social #myeloma program. #hematology
bsky.app/profile/ajai...
bsky.app/profile/ajai...
What a win for myeloma research at Fred Hutch!!! Welcome Madhav!
December 7, 2024 at 4:35 PM
What a win for myeloma research at Fred Hutch!!! Welcome Madhav!
Reposted by Simone Minnie
Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Paper: Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment
ash.confex.com
December 6, 2024 at 6:23 PM
Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
This might just end up being a PNW nature shots account for the next couple of days 😅 It’s so beautiful here!
December 4, 2024 at 9:17 PM
This might just end up being a PNW nature shots account for the next couple of days 😅 It’s so beautiful here!
Break from scientific programming to say that the PNW is truly one of the most beautiful places I’ve ever lived!
December 4, 2024 at 2:02 AM
Break from scientific programming to say that the PNW is truly one of the most beautiful places I’ve ever lived!
This was one of the most useful courses I’ve ever done. Highly recommend. Don’t walk, run!!!
Applications for the 2025 #ASTCT Translational Science Training Course are now open! This course provides an opportunity for lab-based PhDs/MDs to develop their research project into a "presentation-ready" talk. #bmtsm #CARTcells #TcellRx #genetherapy Learn more: www.astct.org/Meetings/Tra...
December 1, 2024 at 3:36 PM
This was one of the most useful courses I’ve ever done. Highly recommend. Don’t walk, run!!!
Reposted by Simone Minnie
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 29, 2024 at 8:04 PM
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Presenting this paper at journal club tomorrow and I’m actually so excited to share it with the lab. I’ve said it at the other place and I’ll say it here, it’s just a beautiful paper!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer - Nature
Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8+ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against...
www.nature.com
November 24, 2024 at 9:24 PM
Presenting this paper at journal club tomorrow and I’m actually so excited to share it with the lab. I’ve said it at the other place and I’ll say it here, it’s just a beautiful paper!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Simone Minnie
If you're interested in Stem cell transplant and/or Cellular Therapy this is the list #bmtsm #CARTcells #leusm #mmsm #lymsm #MedSky #TcellRx go.bsky.app/7xxh8WW
November 22, 2024 at 2:33 PM
If you're interested in Stem cell transplant and/or Cellular Therapy this is the list #bmtsm #CARTcells #leusm #mmsm #lymsm #MedSky #TcellRx go.bsky.app/7xxh8WW
Reposted by Simone Minnie
Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay
Tay et al. demonstrate an antigen-specific assay producing exhausted T cells that
reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion
progression and validate t...
www.cell.com
November 16, 2024 at 7:26 PM
Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay
www.cell.com/cell-reports...
www.cell.com/cell-reports...
I think one of the most important parts of mentoring is having empathy for your trainees. Firstly, things being harder now for junior people doesn’t mean that things weren’t hard for you at the time. Ie. I would NEVER have gotten into a PhD program these days with my track record back then.
November 20, 2024 at 8:23 PM
I think one of the most important parts of mentoring is having empathy for your trainees. Firstly, things being harder now for junior people doesn’t mean that things weren’t hard for you at the time. Ie. I would NEVER have gotten into a PhD program these days with my track record back then.
Reposted by Simone Minnie
CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.
November 20, 2024 at 7:33 PM
CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.