Siddu
@siddu.bsky.social
Siddhardha (Siddu) Maligireddy
MD/PhD Trainee at the University of Colorado School of Medicine
Currently interested in pediatric hematology/oncology and RNA post-transcriptional regulation
Ex-NCI post-bacc fellow
All views are my own
MD/PhD Trainee at the University of Colorado School of Medicine
Currently interested in pediatric hematology/oncology and RNA post-transcriptional regulation
Ex-NCI post-bacc fellow
All views are my own
Reposted by Siddu
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
November 13, 2025 at 9:26 AM
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Reposted by Siddu
So… that’s an outstanding translational study!
Phase behavior of Cacio e Pepe sauce
arxiv.org/abs/2501.00536
Phase behavior of Cacio e Pepe sauce
arxiv.org/abs/2501.00536
Phase behavior of Cacio e Pepe sauce
``Pasta alla Cacio e pepe'' is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect texture and creaminess of the sauce ca...
arxiv.org
September 6, 2025 at 5:35 PM
So… that’s an outstanding translational study!
Phase behavior of Cacio e Pepe sauce
arxiv.org/abs/2501.00536
Phase behavior of Cacio e Pepe sauce
arxiv.org/abs/2501.00536
Reposted by Siddu
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
July 26, 2025 at 2:14 PM
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
Reposted by Siddu
Last Saturday morning ☕ saved for this gem:
www.science.org/doi/10.1126/...
CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
www.science.org/doi/10.1126/...
CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
April 5, 2025 at 2:10 PM
Last Saturday morning ☕ saved for this gem:
www.science.org/doi/10.1126/...
CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
www.science.org/doi/10.1126/...
CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
Reposted by Siddu
** It's happening!! **
We managed to convince Google to open source PebbleOS. Took a while, but they just did it today! github.com/google/pebble
With that, we're bringing Pebble back! I blogged about it - ericmigi.com/blog/why-wer...
We managed to convince Google to open source PebbleOS. Took a while, but they just did it today! github.com/google/pebble
With that, we're bringing Pebble back! I blogged about it - ericmigi.com/blog/why-wer...
Why We’re Bringing Pebble Back
Eight years later, you still can’t beat a Pebble
ericmigi.com
January 28, 2025 at 12:03 AM
** It's happening!! **
We managed to convince Google to open source PebbleOS. Took a while, but they just did it today! github.com/google/pebble
With that, we're bringing Pebble back! I blogged about it - ericmigi.com/blog/why-wer...
We managed to convince Google to open source PebbleOS. Took a while, but they just did it today! github.com/google/pebble
With that, we're bringing Pebble back! I blogged about it - ericmigi.com/blog/why-wer...
Reposted by Siddu
Researchers engineered Escherichia coli bacteria to express an enzyme derived from sea sponges, which polymerizes bioglass from silica, allowing the bacteria to self-assemble lenses that focus light into narrow, intense beams. In PNAS: www.pnas.org/doi/full/10....
December 19, 2024 at 9:27 PM
Researchers engineered Escherichia coli bacteria to express an enzyme derived from sea sponges, which polymerizes bioglass from silica, allowing the bacteria to self-assemble lenses that focus light into narrow, intense beams. In PNAS: www.pnas.org/doi/full/10....
Reposted by Siddu
Reposted by Siddu
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 19, 2024 at 8:13 PM
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
Reposted by Siddu
Indeed, I wrote my final editorial at Science “On Privilege” on this topic. This lack of feeling intimidated by faculty would pay huge dividends.
7/n
www.science.org/doi/pdf/10.1...
7/n
www.science.org/doi/pdf/10.1...
December 8, 2024 at 1:26 PM
Indeed, I wrote my final editorial at Science “On Privilege” on this topic. This lack of feeling intimidated by faculty would pay huge dividends.
7/n
www.science.org/doi/pdf/10.1...
7/n
www.science.org/doi/pdf/10.1...
Reposted by Siddu
Been catching up on the literature en route back to IL from Dagstuhl, including this impressive Cas13-mediated lncRNA KD screen in human cells. Things that surprised me: www.cell.com/cell/fulltex...
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
Massively parallel CRISPR-Cas13 screens in multiple human cell lines uncover universally essential and context-specific essential lncRNAs that exhibit dynamic expression during development and in specific tumor types, and these lncRNAs function independently from neighboring protein-coding genes.
www.cell.com
December 6, 2024 at 2:07 PM
Been catching up on the literature en route back to IL from Dagstuhl, including this impressive Cas13-mediated lncRNA KD screen in human cells. Things that surprised me: www.cell.com/cell/fulltex...
Reposted by Siddu
Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
www.science.org
December 5, 2024 at 9:36 PM
Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Siddu
LOOK at this handsome American Crow fledgling! 😍🖤 His parents are valiantly protecting him from humans, off-leash dogs, and other predators. This is the same kiddo my fellow rescuer and I have been checking on since yesterday. She has a real camera that snaps gorgeous shots like this. 🪶
June 25, 2024 at 12:01 AM
LOOK at this handsome American Crow fledgling! 😍🖤 His parents are valiantly protecting him from humans, off-leash dogs, and other predators. This is the same kiddo my fellow rescuer and I have been checking on since yesterday. She has a real camera that snaps gorgeous shots like this. 🪶
Reposted by Siddu
I will never recover from this student email.
November 27, 2023 at 9:48 PM
I will never recover from this student email.
Reposted by Siddu
This painting of a slug by 18th century Japanese painter Nagasawa Rosetsu is my very favorite thing today
November 27, 2023 at 11:23 PM
This painting of a slug by 18th century Japanese painter Nagasawa Rosetsu is my very favorite thing today
Reposted by Siddu
I think of my iPhone as a sort of sketchbook for photos I might take some day — or photos that I ought to have taken but probably never will.
Here, the beautiful Queensland University of Technology, Garden Point Campus, Brisbane.
Here, the beautiful Queensland University of Technology, Garden Point Campus, Brisbane.
November 22, 2023 at 3:55 AM
I think of my iPhone as a sort of sketchbook for photos I might take some day — or photos that I ought to have taken but probably never will.
Here, the beautiful Queensland University of Technology, Garden Point Campus, Brisbane.
Here, the beautiful Queensland University of Technology, Garden Point Campus, Brisbane.
Reposted by Siddu
Check out our thoughts on celebrating a century of Warburg! Honored to be able to contribute to this piece 🙏
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 22, 2023 at 12:21 PM
Check out our thoughts on celebrating a century of Warburg! Honored to be able to contribute to this piece 🙏
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Siddu
We are offering a free interactive webinar on Peakvisor, a specialist mountaineering tool, which has key applications for open-source research with its 3D mapping software. The course is run by our tech fellow Sophie Tedling this month, sign up here: www.bellingcat.com/workshops/oc...
October 19-20: How to Use PeakVisor in Open Source Investigations [Webinar] - bellingcat
Our tech fellow Sophie Tedling is offering two free webinars on PeakVisor, a powerful 3D mapping tool that can be used in open source investigations, on October 19 and 20. You can sign up for the firs...
www.bellingcat.com
October 12, 2023 at 3:15 PM
We are offering a free interactive webinar on Peakvisor, a specialist mountaineering tool, which has key applications for open-source research with its 3D mapping software. The course is run by our tech fellow Sophie Tedling this month, sign up here: www.bellingcat.com/workshops/oc...
Reposted by Siddu
New faculty position in Gene Regulation at Penn State!
Come join the fantastic collaborative environment in the Center for Eukaryotic Gene Regulation ( www.cegr.psu.edu )!
Review of applications starts Nov. 1st
🧪🧬🔄🖥️
psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...
Come join the fantastic collaborative environment in the Center for Eukaryotic Gene Regulation ( www.cegr.psu.edu )!
Review of applications starts Nov. 1st
🧪🧬🔄🖥️
psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...
Faculty Position in Gene Regulation at Penn State
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
October 3, 2023 at 6:37 PM
New faculty position in Gene Regulation at Penn State!
Come join the fantastic collaborative environment in the Center for Eukaryotic Gene Regulation ( www.cegr.psu.edu )!
Review of applications starts Nov. 1st
🧪🧬🔄🖥️
psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...
Come join the fantastic collaborative environment in the Center for Eukaryotic Gene Regulation ( www.cegr.psu.edu )!
Review of applications starts Nov. 1st
🧪🧬🔄🖥️
psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...
Reposted by Siddu
Chromatin folds into dynamic loops that are continuously created, extended and positioned by structural maintenance of chromosomes protein complexes, such as condensin & cohesin, & their regulators, including CTCF, in a highly dynamic process known as loop extrusion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 5, 2023 at 2:10 AM
Chromatin folds into dynamic loops that are continuously created, extended and positioned by structural maintenance of chromosomes protein complexes, such as condensin & cohesin, & their regulators, including CTCF, in a highly dynamic process known as loop extrusion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Siddu
Hello BlueSky 👋. Time for our first paper alert 🚨: Thrilled to share the latest work from my group revealing how a host RNA-binding protein orchestrates SARS-CoV-2 RNA synthesis in human cells. Now out in Cell @CellPress: www.cell.com/cell/fulltex...
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Mapping of subgenome-resolved SARS-CoV-2 RNA-protein interactions reveals that the
host protein SND1 binds negative-sense SARS-CoV-2 RNA and promotes viral RNA synthesis
by recruiting NSP9, which like...
www.cell.com
October 4, 2023 at 8:39 AM
Hello BlueSky 👋. Time for our first paper alert 🚨: Thrilled to share the latest work from my group revealing how a host RNA-binding protein orchestrates SARS-CoV-2 RNA synthesis in human cells. Now out in Cell @CellPress: www.cell.com/cell/fulltex...
Reposted by Siddu
The world of contagious cancer keeps getting weirder. Here's my story on how these quasi-parasites have been floating through the ocean for perhaps thousands of years. tinyurl.com/5xubysfw [Gift link] 🧪
October 2, 2023 at 3:06 PM
The world of contagious cancer keeps getting weirder. Here's my story on how these quasi-parasites have been floating through the ocean for perhaps thousands of years. tinyurl.com/5xubysfw [Gift link] 🧪