Dr. Shivani Ruparel
@shivanibr.bsky.social
Professor & Director of Research. Studies #orofacialpain, #cancerpain,#oralcancer . Love #travel ( blog at http://mytripscripts.com), #tennis and singing.
I was extremely lucky to receive two RO1s in the current climate literally just before the fiscal year end and government shutdown🙏 I so wish this was the story of all academic scientists in the US. #savescience news.uthscsa.edu/school-of-de...
School of Dentistry at UT Health San Antonio awarded $6 million total to study treatment, pain management for oral cancer - UT Health San Antonio
Three multi-year NIH grants target painful disease with low survival rate Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Nov. 7, 2025 – Researchers at the School of Dentistry at ...
news.uthscsa.edu
November 7, 2025 at 3:06 PM
I was extremely lucky to receive two RO1s in the current climate literally just before the fiscal year end and government shutdown🙏 I so wish this was the story of all academic scientists in the US. #savescience news.uthscsa.edu/school-of-de...
Reposted by Dr. Shivani Ruparel
Original: Drs. Merlo, @shivanibr.bsky.social et al. discovered that TrkBT1, not full-length TrkB, is the main isoform in trigeminal nociceptors. It modulates BDNF-induced sensitization and survival, redefining TrkBT1 as an active player in pain signaling
Full: www.jpain.org/article/S152...
Full: www.jpain.org/article/S152...
June 23, 2025 at 12:31 PM
Original: Drs. Merlo, @shivanibr.bsky.social et al. discovered that TrkBT1, not full-length TrkB, is the main isoform in trigeminal nociceptors. It modulates BDNF-induced sensitization and survival, redefining TrkBT1 as an active player in pain signaling
Full: www.jpain.org/article/S152...
Full: www.jpain.org/article/S152...
My latest travel Post on Sedona AZ: A Relaxing getaway for all age groups. #travel #sedona #arizona trips #redrocks #americandesert mytripscripts.com/2025/05/26/c...
Cool Trails & Red Rock Tales: A December Getaway to Sedona
There are some places that wrap you in a warm hug the moment you arrive, and Sedona in December is one of them. Nestled amidst towering red rock formations, this Arizona gem offers a tranquil retre…
mytripscripts.com
May 26, 2025 at 6:20 PM
My latest travel Post on Sedona AZ: A Relaxing getaway for all age groups. #travel #sedona #arizona trips #redrocks #americandesert mytripscripts.com/2025/05/26/c...
What we do in the newly established Center of Pain Therapeutics and Addiction Research (CPTAR) in School of Dentistry @uthealthsa.bsky.social #painresearch magazines.uthscsa.edu/schools/2025...
Looking beyond opioids - Magazines of the Schools at UT Health San Antonio
A revolution in pain exploration has been launched with the school’s new Center for Pain Therapeutics and Addiction Research. Interdisciplinary collaboration is helping investigators study non-opioid ...
magazines.uthscsa.edu
May 21, 2025 at 7:54 PM
What we do in the newly established Center of Pain Therapeutics and Addiction Research (CPTAR) in School of Dentistry @uthealthsa.bsky.social #painresearch magazines.uthscsa.edu/schools/2025...
For early-stage investigators grants.nih.gov/grants/guide...
NOT-OD-25-114: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period NOT-OD-25-114. OD
grants.nih.gov
May 21, 2025 at 5:53 PM
For early-stage investigators grants.nih.gov/grants/guide...
Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...
Truncated TrkB: The predominant TrkB isoform in nociceptors
Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral…
www.sciencedirect.com
May 17, 2025 at 10:49 PM
Our paper in Journal of Pain challenges old labels: TrkB isnt just an A-LTMR marker. Its truncated isoform is expressed and functional in trigeminal nociceptors, opening new avenues for studying the receptor in pathological pain #painresearch www.sciencedirect.com/science/arti...
Congratulations to my student Priya Narayanan for an excellent performance on defending her MS thesis focused on the molecular mechanisms underlying oral mucositis @uthealthsa.bsky.social. I am a proud mentor today. #teachingisrewarding #graduateeducation
May 14, 2025 at 1:58 AM
Congratulations to my student Priya Narayanan for an excellent performance on defending her MS thesis focused on the molecular mechanisms underlying oral mucositis @uthealthsa.bsky.social. I am a proud mentor today. #teachingisrewarding #graduateeducation
New paper out from my lab and Dr. Akopian's lab. First of its kind to characterize mechanically-gated trigeminal neurons in non-rodent higher order species. #painresearch #nonrodentmodels www.eneuro.org/content/earl...
Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates
Pain sensation often involves mechanical modalities. Mechanically activated (MA) ion channels on sensory neurons underly responsiveness to mechanical stimuli. MA current properties have mainly been de...
www.eneuro.org
May 3, 2025 at 12:33 PM
New paper out from my lab and Dr. Akopian's lab. First of its kind to characterize mechanically-gated trigeminal neurons in non-rodent higher order species. #painresearch #nonrodentmodels www.eneuro.org/content/earl...
UT Health San Antonio ranks among the top 50 medical schools in the nation for National Institutes of Health research funding.
news.uthscsa.edu/ut-health-sa...
news.uthscsa.edu/ut-health-sa...
UT Health San Antonio’s accelerated rise: Advancing innovation, research and national impact - UT Health San Antonio
UT Health San Antonio’s Accelerated Rise: Advancing Innovation, Research and National Impact
news.uthscsa.edu
April 1, 2025 at 10:36 PM
UT Health San Antonio ranks among the top 50 medical schools in the nation for National Institutes of Health research funding.
news.uthscsa.edu/ut-health-sa...
news.uthscsa.edu/ut-health-sa...
Reposted by Dr. Shivani Ruparel
Had a blast speaking and catching up w/ Nicole Scheff, @flybottleescape.bsky.social @robgereau.bsky.social @laurenslosky.bsky.social et al at the Center for Adv PainTher and Res (CAPToR) @ufresearch.bsky.social.Thank you @khannalabuf.bsky.social and @maykhanna.bsky.social for hosting us.
April 1, 2025 at 6:12 PM
Had a blast speaking and catching up w/ Nicole Scheff, @flybottleescape.bsky.social @robgereau.bsky.social @laurenslosky.bsky.social et al at the Center for Adv PainTher and Res (CAPToR) @ufresearch.bsky.social.Thank you @khannalabuf.bsky.social and @maykhanna.bsky.social for hosting us.
Reposted by Dr. Shivani Ruparel
#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer research needs neuroscience and neuroscientists - Nature Neuroscience
The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...
www.nature.com
March 21, 2025 at 7:11 AM
#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Yet another reason to be proud of @uthealthsa.bsky.social news.uthscsa.edu/ut-health-sa...
UT Health San Antonio earns top Carnegie classification for research, doctorate awards - UT Health San Antonio
The University of Texas Health Science Center at San Antonio earned a Research 1 (R1) designation from the American Council on Education and the Carnegie Foundation for the Advancement of Teaching in ...
news.uthscsa.edu
February 20, 2025 at 12:03 PM
Yet another reason to be proud of @uthealthsa.bsky.social news.uthscsa.edu/ut-health-sa...
Interesting article "suggesting a need to recalibrate recruitment expectations. Even moderately above-average individuals on these key dimensions may merit greater recognition due to their scarcity".
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The number of exceptional people: Fewer than 85 per 1 million across key traits
Cognitive biases can lead to overestimating the expected prevalence of exceptional multi-talented candidates, leading to potential dissatisfaction in …
www.sciencedirect.com
February 2, 2025 at 3:54 AM
Interesting article "suggesting a need to recalibrate recruitment expectations. Even moderately above-average individuals on these key dimensions may merit greater recognition due to their scarcity".
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Dr. Shivani Ruparel
Anyone interested in a PhD in pain research, we have a fully-funded position available in the Weir lab.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow on FindAPhD.com
PhD Project - Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling at University of Glasgow, listed on FindAPhD.com
www.findaphd.com
January 17, 2025 at 9:14 AM
Anyone interested in a PhD in pain research, we have a fully-funded position available in the Weir lab.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Dr. Shivani Ruparel
Reposted by Dr. Shivani Ruparel
@dereklowe.bsky.social on the evolving suzetrigine and acute and chronic pain story: www.science.org/content/blog... Certainly going to be some interesting times ahead in this area. I agree with him, I think the patient experience in the real world is going to be a huge determining factor...
The Pain Comes With the Territory
www.science.org
January 14, 2025 at 4:24 PM
@dereklowe.bsky.social on the evolving suzetrigine and acute and chronic pain story: www.science.org/content/blog... Certainly going to be some interesting times ahead in this area. I agree with him, I think the patient experience in the real world is going to be a huge determining factor...
Reposted by Dr. Shivani Ruparel
Hope springs anew in 2025! 🌸 Here's to a year of breakthroughs in pain relief and brighter, pain-free days ahead for chronic pain patients. #PainRelief
NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...
NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...
NaV1.8 inhibitor poised to provide opioid-free pain relief
Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic.
www.nature.com
January 7, 2025 at 1:39 AM
Hope springs anew in 2025! 🌸 Here's to a year of breakthroughs in pain relief and brighter, pain-free days ahead for chronic pain patients. #PainRelief
NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...
NaV1.8 inhibitor poised to provide opioid-free pain relief www.nature.com/articles/d41...
Wishing everyone and your families a very safe, healthy and an uneventful 2025! May the magic continue in all your lives😍
January 1, 2025 at 1:49 PM
Wishing everyone and your families a very safe, healthy and an uneventful 2025! May the magic continue in all your lives😍
My uncle in his retirement graduated from flying school, bought a plane and then built it, to tour around the world. And now I get to ride in it for free. I feel so royal 😬
December 30, 2024 at 2:35 AM
My uncle in his retirement graduated from flying school, bought a plane and then built it, to tour around the world. And now I get to ride in it for free. I feel so royal 😬
Reposted by Dr. Shivani Ruparel
arthritis-research.biomedcentral.com/articles/10.... on the role of macrophages in experimental OA pain
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage - Arthritis Research & Therapy
Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions report...
arthritis-research.biomedcentral.com
December 28, 2024 at 6:17 PM
arthritis-research.biomedcentral.com/articles/10.... on the role of macrophages in experimental OA pain
Reposted by Dr. Shivani Ruparel
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
Truncated TrkB: The predominant TrkB Isoform in Nociceptors
Truncated form of the tropomyosin receptor kinase B isoform (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sens...
www.biorxiv.org
December 27, 2024 at 11:54 PM
BOOM! Great stuff on the truncated TrkB isoform in nociception and nociceptors from @shivanibr.bsky.social's lab #painresearch www.biorxiv.org/content/10.1...
Reposted by Dr. Shivani Ruparel
POG, from dried roots of Saposhnikovia divaricata, may help treat #OA by regulating lncRNA XIST & Nav1.7. POG improves cartilage damage, reduces inflammation & chondrocyte apoptosis.
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of osteoarthritis: Based on lncRNA XIST regulation of Nav1.7
LncRNA XIST and Nav1.7 have been identified to be significantly associated with the onset of osteoarthritis. Prim-O-glucosylcimifugin (POG) has antiin…
www.sciencedirect.com
December 21, 2024 at 10:25 PM
POG, from dried roots of Saposhnikovia divaricata, may help treat #OA by regulating lncRNA XIST & Nav1.7. POG improves cartilage damage, reduces inflammation & chondrocyte apoptosis.
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...
Protective mechanism of Prim-O-glucosylcimifugin in the treatment of o... www.sciencedirect.com/science/arti...
Reposted by Dr. Shivani Ruparel
BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...
eEF2K regulates pain through translational control of BDNF
mRNA translation is integral to pain, yet the key regulatory factors and their target mRNAs are unclear. Here, we uncover a mechanism that bridges nox…
www.sciencedirect.com
December 21, 2024 at 1:30 PM
BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...