Shane Herbert
@shaneherbert.bsky.social
Cell & developmental biologist. Exploring instructive cues encoded in cell shape – in vascular development, morphogenesis and beyond. https://herbertlab.com/ @uniofmanchester.bsky.social @fbmh-uom.bsky.social @mcf-uom.bsky.social
Pinned
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by Shane Herbert
🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control.
bit.ly/4mhMvsU
bit.ly/4mhMvsU
Cell state-specific cytoplasmic density controls spindle architecture and scaling - Nature Cell Biology
Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...
bit.ly
August 2, 2025 at 6:54 PM
🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control.
bit.ly/4mhMvsU
bit.ly/4mhMvsU
If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, and what happens when this goes wrong, please check out our new manuscript – mRNA trafficking controls cell-size-scaled organelle dynamics! www.nature.com/articles/s41...
mRNA trafficking directs cell-size-scaling of mitochondria distribution and function - Nature Communications
How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-sca...
www.nature.com
August 1, 2025 at 6:30 AM
If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, and what happens when this goes wrong, please check out our new manuscript – mRNA trafficking controls cell-size-scaled organelle dynamics! www.nature.com/articles/s41...
Reposted by Shane Herbert
Looking foward to the Northern(ish) Developmental Biology Meeting 2025 next week @sheffielduni.bsky.social! Thanks to the organisers @shaneherbert.bsky.social Raman Das @tsakiridis.bsky.social @kyracampbelllab.bsky.social
July 3, 2025 at 8:58 AM
Looking foward to the Northern(ish) Developmental Biology Meeting 2025 next week @sheffielduni.bsky.social! Thanks to the organisers @shaneherbert.bsky.social Raman Das @tsakiridis.bsky.social @kyracampbelllab.bsky.social
Frictiotaxis - amazing!
Check out our new work @natcomms.nature.com! @mayorlab.bsky.social discovered that cells perform durotaxis even without focal adhesions. How? Well, we found that they actually follow friction gradients — a new mode of directed cell migration that we call frictiotaxis!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Frictiotaxis underlies focal adhesion-independent durotaxis - Nature Communications
Cells typically migrate toward stiffer substrates via durotaxis, relying on focal adhesions. Here, the authors show that confined cells can migrate up friction gradients without focal adhesions, revea...
www.nature.com
May 9, 2025 at 8:36 PM
Frictiotaxis - amazing!
Cool - ever multitalented endothelial cells!
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
May 9, 2025 at 9:07 AM
Cool - ever multitalented endothelial cells!
It's great to have media attention on our recent paper, but, some of these 'news' articles are completely wacky! 🤣
May 9, 2025 at 7:08 AM
It's great to have media attention on our recent paper, but, some of these 'news' articles are completely wacky! 🤣
I really hope I can make this - and seems crazy that this is the 1st UK meeting! Should be excellent!
Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! 🐠 Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...
May 9, 2025 at 6:05 AM
I really hope I can make this - and seems crazy that this is the 1st UK meeting! Should be excellent!
Bit of a nerdy dream for our paper to be covered by @newscientist.com! And lovely kind words from @buzzbaum.bsky.social. Just a shame that the daughter cells on the cover image are round and symmetric 🤣. www.newscientist.com/article/2478... www.newscientist.com/article/2478...
Our cells can divide in a completely unexpected way
A different kind of human cell division could improve our understanding of cancer and help us grow specific tissues
www.newscientist.com
May 7, 2025 at 5:40 PM
Bit of a nerdy dream for our paper to be covered by @newscientist.com! And lovely kind words from @buzzbaum.bsky.social. Just a shame that the daughter cells on the cover image are round and symmetric 🤣. www.newscientist.com/article/2478... www.newscientist.com/article/2478...
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...