Sergio Dellepiane
@sergiodellep.bsky.social
Nephrologist in pharma industry.
I’m reading about Gene and her difficulties in expressing herself.. great book. Nice storytelling and fluent writing. The cat loves it too
November 23, 2025 at 1:26 PM
I’m reading about Gene and her difficulties in expressing herself.. great book. Nice storytelling and fluent writing. The cat loves it too
This is the future. Cheap, clean, stable. I never thought that solar could ever prevent more than 30-40% of the emissions. Here there is a 100% potential
Geothermal’s time has finally come
economist.com/interactive/...
from The Economist
Geothermal’s time has finally come
economist.com/interactive/...
from The Economist
Geothermal’s time has finally come
This source of energy could become bigger than nuclear
economist.com
November 21, 2025 at 10:00 PM
This is the future. Cheap, clean, stable. I never thought that solar could ever prevent more than 30-40% of the emissions. Here there is a 100% potential
Geothermal’s time has finally come
economist.com/interactive/...
from The Economist
Geothermal’s time has finally come
economist.com/interactive/...
from The Economist
Reposted by Sergio Dellepiane
Advice on how to be miserable: the key is insecure selfishness
November 21, 2025 at 1:04 PM
Advice on how to be miserable: the key is insecure selfishness
I remember practicing in Italy and writing 12-page discharge summaries addressed to the PCP. The patient was used as mail delivery system. One day I read a Swedish 1 page letter starting: “Dear Ms Xxx you were diagnosed with a kidney infection, what does that mean?..”
💬 Viewpoint: Trust in medicine has declined due to the #COVID19 pandemic and abundant online health information, highlighting the need for transparent, patient-focused communication. ja.ma/49Qp9aQ
November 16, 2025 at 1:41 PM
I remember practicing in Italy and writing 12-page discharge summaries addressed to the PCP. The patient was used as mail delivery system. One day I read a Swedish 1 page letter starting: “Dear Ms Xxx you were diagnosed with a kidney infection, what does that mean?..”
Reposted by Sergio Dellepiane
Promising results from a new malaria drug offer hope against emerging drug resistance in Africa. In a clinical trial, ganaplacide–lumefantrine (GanLum) cured 97.4% of participants, outperforming an existing treatment, which cured 94%.
go.nature.com/3WTGxnx
go.nature.com/3WTGxnx
First new type of malaria treatment in decades shows promise against drug resistance
If approved, GanLum could be available within a year and a half, according to maker.
go.nature.com
November 12, 2025 at 11:00 PM
Promising results from a new malaria drug offer hope against emerging drug resistance in Africa. In a clinical trial, ganaplacide–lumefantrine (GanLum) cured 97.4% of participants, outperforming an existing treatment, which cured 94%.
go.nature.com/3WTGxnx
go.nature.com/3WTGxnx
Reposted by Sergio Dellepiane
Nature research paper: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
go.nature.com/3LARwjy
go.nature.com/3LARwjy
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology - Nature
An analysis of rare genetic variants identifies three genes—MAP1A, ANO8 and ANK2—that have a role in attention deficit hyperactivity disorder (ADHD) and investigates the potential underlying biological mechanisms.
go.nature.com
November 12, 2025 at 5:40 PM
Nature research paper: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
go.nature.com/3LARwjy
go.nature.com/3LARwjy
You never heard of it also because they change its name every 2 years
Metabolic dysfunction-associated steatotic liver disease, or #MASLD, is the common “noncommunicable disease you’ve probably never heard of.”
Read on to learn more about the push for greater awareness.
Read on to learn more about the push for greater awareness.
“How Many of You Have Heard of MASLD?”
This Medical News article discusses the relatively unknown condition called metabolic dysfunction–associated steatotic liver disease, or MASLD, which is thought to affect approximately a third of adul...
jamanetwork.com
November 11, 2025 at 12:58 AM
You never heard of it also because they change its name every 2 years
Nothing makes @theeconomistnews.bsky.social happy! That’s why I love the journal.. always finding a different angle 📐
November 10, 2025 at 9:02 PM
Nothing makes @theeconomistnews.bsky.social happy! That’s why I love the journal.. always finding a different angle 📐
Blue light exposure during the day improves sleep quality. So the famous “blue filters” are not useless.. are harmful!
open.spotify.com/episode/51en...
open.spotify.com/episode/51en...
Audio long read: How to get the best night’s sleep — what the science says
open.spotify.com
November 9, 2025 at 11:56 AM
Blue light exposure during the day improves sleep quality. So the famous “blue filters” are not useless.. are harmful!
open.spotify.com/episode/51en...
open.spotify.com/episode/51en...
Reposted by Sergio Dellepiane
COMMENT | J Trevaskis, DG Parkes, AA Young:
On the 20th anniversary of exenatide, three former employees of Amylin Pharmaceuticals tell the story behind the first approved GLP-1RA 🧪
On the 20th anniversary of exenatide, three former employees of Amylin Pharmaceuticals tell the story behind the first approved GLP-1RA 🧪
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals - Nature Metabolism
The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta), three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs.
bit.ly
October 29, 2025 at 5:04 PM
COMMENT | J Trevaskis, DG Parkes, AA Young:
On the 20th anniversary of exenatide, three former employees of Amylin Pharmaceuticals tell the story behind the first approved GLP-1RA 🧪
On the 20th anniversary of exenatide, three former employees of Amylin Pharmaceuticals tell the story behind the first approved GLP-1RA 🧪
Conference in Medicine:
- always on the weekend to allow dr to do shifts
- cool stuff at the end to force ppl to stay
Conference in Finance:
- never weekend for work life balance
- cool stuff in the middle to maximize guest experience
- always on the weekend to allow dr to do shifts
- cool stuff at the end to force ppl to stay
Conference in Finance:
- never weekend for work life balance
- cool stuff in the middle to maximize guest experience
October 29, 2025 at 1:03 PM
Conference in Medicine:
- always on the weekend to allow dr to do shifts
- cool stuff at the end to force ppl to stay
Conference in Finance:
- never weekend for work life balance
- cool stuff in the middle to maximize guest experience
- always on the weekend to allow dr to do shifts
- cool stuff at the end to force ppl to stay
Conference in Finance:
- never weekend for work life balance
- cool stuff in the middle to maximize guest experience
open.substack.com/pub/sergiode...
L’epidemia di ADHD potrebbe essere meno reale di quanto si pensi. Ecco il mio articolo numero 3
L’epidemia di ADHD potrebbe essere meno reale di quanto si pensi. Ecco il mio articolo numero 3
Le diagnosi di ADHD dell’adulto sono completamente fuori controllo
Un sacco di individui ricevono una diagnosi scorretta, spesso gratificante, e con conseguenze problematiche
open.substack.com
October 24, 2025 at 2:58 PM
open.substack.com/pub/sergiode...
L’epidemia di ADHD potrebbe essere meno reale di quanto si pensi. Ecco il mio articolo numero 3
L’epidemia di ADHD potrebbe essere meno reale di quanto si pensi. Ecco il mio articolo numero 3
Reposted by Sergio Dellepiane
Is science getting too competitive?
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
October 19, 2025 at 3:55 PM
Is science getting too competitive?
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Grant applications are skyrocketing and funding rates are decreasing.
Yet the article in Nature fails to mention the potential role that AI/LLMs in driving up grant applications.
It's becoming a lottery.
www.nature.com/articles/d41...).
Secondo post! Parlare di scienza è difficile, e spesso i giornali fanno un sacco di errori
open.substack.com/pub/sergiode...
open.substack.com/pub/sergiode...
Come i giornali torturano la scienza
Scovare e interpretare i dati in modo corretto non è per nulla facile, suscitare stupore sì
open.substack.com
October 10, 2025 at 4:05 PM
Secondo post! Parlare di scienza è difficile, e spesso i giornali fanno un sacco di errori
open.substack.com/pub/sergiode...
open.substack.com/pub/sergiode...
Reposted by Sergio Dellepiane
Longitudinal study in Japanese women found increased serum urate levels several years before menopause, with the largest increase occurring during peri-menopause, particularly in overweight or obese women and those with lower eGFR
Arthritis & Rheumatology
doi.org/10.1002/art....
#Medsky
Arthritis & Rheumatology
doi.org/10.1002/art....
#Medsky
October 7, 2025 at 8:36 PM
Longitudinal study in Japanese women found increased serum urate levels several years before menopause, with the largest increase occurring during peri-menopause, particularly in overweight or obese women and those with lower eGFR
Arthritis & Rheumatology
doi.org/10.1002/art....
#Medsky
Arthritis & Rheumatology
doi.org/10.1002/art....
#Medsky
Il mio primo sub-post. Come il dibattito sul maschilismo in Italia ha abbandonato la scienza
substack.com/@sergiodelle...
substack.com/@sergiodelle...
Su testosterone e patriarcato ci sono molte informazioni inaccurate
Due spiegazioni non necessariamente si escludono a vicenda
substack.com
September 30, 2025 at 2:25 PM
Il mio primo sub-post. Come il dibattito sul maschilismo in Italia ha abbandonato la scienza
substack.com/@sergiodelle...
substack.com/@sergiodelle...
Great episode from the @dwarkesh.bsky.social, by far the best contemporary interviewer, and I mean beyond podcasters, chapeau (pls speak slowly!). The host is simply brilliant.. and a voice out of the choir about “AI, LLM and how you will lose your job tomorrow”
open.spotify.com/episode/3zAX...
open.spotify.com/episode/3zAX...
Richard Sutton – Father of RL thinks LLMs are a dead end
Spotify video
open.spotify.com
September 30, 2025 at 12:23 AM
Great episode from the @dwarkesh.bsky.social, by far the best contemporary interviewer, and I mean beyond podcasters, chapeau (pls speak slowly!). The host is simply brilliant.. and a voice out of the choir about “AI, LLM and how you will lose your job tomorrow”
open.spotify.com/episode/3zAX...
open.spotify.com/episode/3zAX...
Con buone intenzioni, a @ilpost.it state promuovendo stereotipi molto problematici sull’ADHD. In questo momento si sta andando verso una mercificazione della diagnosi e un’esplosione delle diagnosi scorrette. Vi chiedo pubblicamente di rivedere la vostra policy su questo tratto complesso 1/2
Per gli adulti con ADHD non è facile farsi aiutare
Per gli adulti con ADHD non è facile farsi aiutare
In Italia sono più di un milione ad avere il disturbo da deficit di attenzione e iperattività, ma è difficile trovare medici e farmaci giusti
ilpost.link
September 29, 2025 at 10:24 PM
Con buone intenzioni, a @ilpost.it state promuovendo stereotipi molto problematici sull’ADHD. In questo momento si sta andando verso una mercificazione della diagnosi e un’esplosione delle diagnosi scorrette. Vi chiedo pubblicamente di rivedere la vostra policy su questo tratto complesso 1/2
Reposted by Sergio Dellepiane
One of my favorite neuroscience lessons:
When you start something new, it feels like a struggle and requires your entire focus. But it gets easier and you need far less brain power. Things become automatic.
The brain becomes more efficient in a single hour: mrbartonmaths.com/resourcesnew...
When you start something new, it feels like a struggle and requires your entire focus. But it gets easier and you need far less brain power. Things become automatic.
The brain becomes more efficient in a single hour: mrbartonmaths.com/resourcesnew...
September 23, 2025 at 7:44 PM
One of my favorite neuroscience lessons:
When you start something new, it feels like a struggle and requires your entire focus. But it gets easier and you need far less brain power. Things become automatic.
The brain becomes more efficient in a single hour: mrbartonmaths.com/resourcesnew...
When you start something new, it feels like a struggle and requires your entire focus. But it gets easier and you need far less brain power. Things become automatic.
The brain becomes more efficient in a single hour: mrbartonmaths.com/resourcesnew...
Reposted by Sergio Dellepiane
Brazil hopes to turn the tide of dengue with a home-grown vaccine and an army of mosquitoes
go.nature.com/4pveeJf
go.nature.com/4pveeJf
How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus
Outbreaks of dengue are killing thousands of people in South America each year and getting worse. Brazil hopes to turn the tide with a home-grown vaccine and an army of mosquitoes infected with Wolbachia bacteria.
go.nature.com
September 20, 2025 at 1:48 PM
Brazil hopes to turn the tide of dengue with a home-grown vaccine and an army of mosquitoes
go.nature.com/4pveeJf
go.nature.com/4pveeJf
Italy populist government ignored all financial promises, implemented soft austerity and for the first time in forever improved the country rating 😱😱😱. Unexpected twist!
September 20, 2025 at 12:03 AM
Italy populist government ignored all financial promises, implemented soft austerity and for the first time in forever improved the country rating 😱😱😱. Unexpected twist!
Must read. ChatBots can effectively calculate the weight of each source in their answers (backpropagation).
To be best, Chatbots need the best sources.
Thus Chatbots could pay and foster a better internet. A win-win!
But, experience tells us this is usually not the outcome
on.ft.com/47OZ2QV
To be best, Chatbots need the best sources.
Thus Chatbots could pay and foster a better internet. A win-win!
But, experience tells us this is usually not the outcome
on.ft.com/47OZ2QV
September 15, 2025 at 4:03 PM
Must read. ChatBots can effectively calculate the weight of each source in their answers (backpropagation).
To be best, Chatbots need the best sources.
Thus Chatbots could pay and foster a better internet. A win-win!
But, experience tells us this is usually not the outcome
on.ft.com/47OZ2QV
To be best, Chatbots need the best sources.
Thus Chatbots could pay and foster a better internet. A win-win!
But, experience tells us this is usually not the outcome
on.ft.com/47OZ2QV
So many times we heard that Biology folks were behind.. clearly not as smart of tech bros. Then tech people came to pharma and had a humbling experience. So far AI companies are delivering at a slower pace. It may change really soon.
on.ft.com/48ay8D0 Why is AI struggling to discover new drugs?
on.ft.com/48ay8D0 Why is AI struggling to discover new drugs?
September 10, 2025 at 12:22 PM
So many times we heard that Biology folks were behind.. clearly not as smart of tech bros. Then tech people came to pharma and had a humbling experience. So far AI companies are delivering at a slower pace. It may change really soon.
on.ft.com/48ay8D0 Why is AI struggling to discover new drugs?
on.ft.com/48ay8D0 Why is AI struggling to discover new drugs?
Reposted by Sergio Dellepiane
Extreme views are heavily over-represented on social media
Social platforms’ tendency to reward hostile content creates incentives that systematically reward simplistic messages and extreme positions and this fuels populism www.ft.com/content/9251... via @jburnmurdoch.ft.com
Social platforms’ tendency to reward hostile content creates incentives that systematically reward simplistic messages and extreme positions and this fuels populism www.ft.com/content/9251... via @jburnmurdoch.ft.com
September 8, 2025 at 10:02 PM
Extreme views are heavily over-represented on social media
Social platforms’ tendency to reward hostile content creates incentives that systematically reward simplistic messages and extreme positions and this fuels populism www.ft.com/content/9251... via @jburnmurdoch.ft.com
Social platforms’ tendency to reward hostile content creates incentives that systematically reward simplistic messages and extreme positions and this fuels populism www.ft.com/content/9251... via @jburnmurdoch.ft.com
And you don’t even need to be in the ICU.. once I had a very salty meal right before my PCP appointment. I drank possibly 1.5 L of water. My creatinine was the lowest ever.
The serum creatinine level is a concentration, amount per volume.
If you quickly expand plasma volume by 20%, the Cr will decrease by ~20%, saying nothing of GFR.
Same goes for ALT, WBC, CRP, and other values that we trend and sometimes overinterpret small fluctuations of.
If you quickly expand plasma volume by 20%, the Cr will decrease by ~20%, saying nothing of GFR.
Same goes for ALT, WBC, CRP, and other values that we trend and sometimes overinterpret small fluctuations of.
September 7, 2025 at 5:01 PM
And you don’t even need to be in the ICU.. once I had a very salty meal right before my PCP appointment. I drank possibly 1.5 L of water. My creatinine was the lowest ever.