How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?

Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)

www.nature.com/articles/s41...

Réparer l’ADN cassé : comment les polymérases X peuvent-elles sauver nos cellules ?

🤝 @ipbstoulouse.bsky.social‬ ‪ @sebastien-britton.bsky.social‬
👉 Lire l'article dans ‪ @natcomms.nature.com‬
buff.ly/n2gO2qZ

The Institute of Pharmacology and Structural Biology (IPBS) of Toulouse, France, is seeking for motivated postdoctoral researchers to apply for Marie Skłodowska-Curie and/or EMBO fellowships on specific projects (including one in the DDR team 😉 ) www.ipbs.fr/call-for-pos... Plse circulate or apply!

Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...

I'm honoured to speak at the upcoming Genome Instability & Cancer Conference, celebrating the legacy of Angelos Constantinou. His pioneering work transformed our understanding of DNA repair. Register now to join us near his home town in France in March! www.tribute2angelos.fr/page/home/

Hi DNA/RNA folks!
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested

Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go!
go.bsky.app/DDpDuvo

ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone!
go.bsky.app/9jdDNxG

New updates to the upcoming DNA repair/Genome Stability conferences over 2024/2025. Please let me know if you have meetings to add:
docs.google.com/spreadsheets...