Seamus Curran
@seamuscurran.bsky.social
Researcher at the John Innes Centre studying the biochemistry of meiosis // hiking // running // birding // Leicester city fc fan 🌼🐦🦊
Exciting opportunity for a 4-year fully funded PhD Studentship (starting Oct 2025) with the Morgan lab to study the link between temperature and meiotic crossover rate in plants!
www.findaphd.com/phds/project...
John Innes Centre/Meiosis/crop development
www.findaphd.com/phds/project...
John Innes Centre/Meiosis/crop development
Investigating the influence of temperature on meiotic recombination (MORGAN_J25RS) at John Innes Centre on FindAPhD.com
PhD Project - Investigating the influence of temperature on meiotic recombination (MORGAN_J25RS) at John Innes Centre, listed on FindAPhD.com
www.findaphd.com
March 13, 2025 at 1:19 PM
Exciting opportunity for a 4-year fully funded PhD Studentship (starting Oct 2025) with the Morgan lab to study the link between temperature and meiotic crossover rate in plants!
www.findaphd.com/phds/project...
John Innes Centre/Meiosis/crop development
www.findaphd.com/phds/project...
John Innes Centre/Meiosis/crop development
Reposted by Seamus Curran
ChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...
March 6, 2025 at 11:06 PM
ChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Seamus Curran
New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Molecular determinants of condensate composition
Biomolecular condensates are non-stochiometric assemblies that organize cellular matter
in space and time. Despite much work, many questions remain regarding what determines
the recruitment and exclus...
www.cell.com
January 17, 2025 at 10:23 AM
New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Seamus Curran
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
January 17, 2025 at 11:17 AM
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Reposted by Seamus Curran
🔥🔥🔥🔥🔥🔥
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
science.org
January 18, 2025 at 2:27 AM
🔥🔥🔥🔥🔥🔥
Reposted by Seamus Curran
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Reposted by Seamus Curran
Nucleosome spacing can fine-tune higher order chromatin assembly [labs of Rosana Collepardo-Guevara and Michael Rosen]
www.biorxiv.org/content/10.1...
▶️phase separation is decided by trade-off between inter- and intramolecular nucleosome stacking, favoured by 10N+5 and 10N bp linkers, respectively
www.biorxiv.org/content/10.1...
▶️phase separation is decided by trade-off between inter- and intramolecular nucleosome stacking, favoured by 10N+5 and 10N bp linkers, respectively
December 28, 2024 at 8:13 PM
Nucleosome spacing can fine-tune higher order chromatin assembly [labs of Rosana Collepardo-Guevara and Michael Rosen]
www.biorxiv.org/content/10.1...
▶️phase separation is decided by trade-off between inter- and intramolecular nucleosome stacking, favoured by 10N+5 and 10N bp linkers, respectively
www.biorxiv.org/content/10.1...
▶️phase separation is decided by trade-off between inter- and intramolecular nucleosome stacking, favoured by 10N+5 and 10N bp linkers, respectively
Reposted by Seamus Curran
The more I think about it, the more convinced I am that the holy grail here is if this can go beyond predicting ratio of folded to unfolded, to also predicting ratio of folded state A to folded states B, C, D, etc. Example from doi.org/10.1016/j.molcel.2024.04.008 w/ changes in the transporter OCT1
December 11, 2024 at 7:52 AM
The more I think about it, the more convinced I am that the holy grail here is if this can go beyond predicting ratio of folded to unfolded, to also predicting ratio of folded state A to folded states B, C, D, etc. Example from doi.org/10.1016/j.molcel.2024.04.008 w/ changes in the transporter OCT1
Reposted by Seamus Curran
It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates
Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...
pubs.acs.org
December 10, 2024 at 5:14 PM
It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏
Reposted by Seamus Curran
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 6, 2024 at 8:52 PM
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Reposted by Seamus Curran
My latest Research Highlight is now online @natrevmcb.bsky.social!
The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics.
🔗 go.nature.com/3ZpwGH7
OG Paper: go.nature.com/3Baxpnn
The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics.
🔗 go.nature.com/3ZpwGH7
OG Paper: go.nature.com/3Baxpnn
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates - Nature Communications
Cell migration through narrow constrictions during cancer metastasis significantly deforms the nucleus, creating mechanical stress on chromatin. Here, the authors reveal that such chromatin deformatio...
go.nature.com
December 5, 2024 at 2:31 PM
My latest Research Highlight is now online @natrevmcb.bsky.social!
The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics.
🔗 go.nature.com/3ZpwGH7
OG Paper: go.nature.com/3Baxpnn
The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics.
🔗 go.nature.com/3ZpwGH7
OG Paper: go.nature.com/3Baxpnn
Reposted by Seamus Curran
Meet the CALVADOS RNA model
Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪
Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪
November 29, 2024 at 8:25 AM
Meet the CALVADOS RNA model
Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪
Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪
Reposted by Seamus Curran
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
A timely release of this story... as it is a great setup to the next one, coming soon!!
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM - Nature Communications
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...
www.nature.com
December 2, 2024 at 11:57 PM
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
A timely release of this story... as it is a great setup to the next one, coming soon!!
Reposted by Seamus Curran
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology
Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...
www.nature.com
November 28, 2024 at 12:48 PM
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Reposted by Seamus Curran
This is pretty impressive--closing the gap between superresolution microscopy and structural biology is one of the Holy Grails and this is a big step in that direction--check out the nuclear pore imaging
November 29, 2024 at 12:27 AM
This is pretty impressive--closing the gap between superresolution microscopy and structural biology is one of the Holy Grails and this is a big step in that direction--check out the nuclear pore imaging
Reposted by Seamus Curran
This week in @science.org Molecular basis of #mRNA delivery to the bacterial #ribosome www.science.org/doi/10.1126/...
Molecular basis of mRNA delivery to the bacterial ribosome
Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the Shine-Da...
www.science.org
November 29, 2024 at 12:37 PM
This week in @science.org Molecular basis of #mRNA delivery to the bacterial #ribosome www.science.org/doi/10.1126/...
Reposted by Seamus Curran
Very nice article by Danielle Gerhard in The Scientist on
“The Dynamic Lives of Intrinsically Disordered Proteins”
with quotes from Gabi Heller, @alexholehouse.bsky.social and myself about our shared love of and fascination with these proteins
www.the-scientist.com/the-dynamic-...
“The Dynamic Lives of Intrinsically Disordered Proteins”
with quotes from Gabi Heller, @alexholehouse.bsky.social and myself about our shared love of and fascination with these proteins
www.the-scientist.com/the-dynamic-...
The Dynamic Lives of Intrinsically Disordered Proteins
Shapeshifting proteins challenge a long-standing maxim in biology.
www.the-scientist.com
September 16, 2024 at 5:02 PM
Very nice article by Danielle Gerhard in The Scientist on
“The Dynamic Lives of Intrinsically Disordered Proteins”
with quotes from Gabi Heller, @alexholehouse.bsky.social and myself about our shared love of and fascination with these proteins
www.the-scientist.com/the-dynamic-...
“The Dynamic Lives of Intrinsically Disordered Proteins”
with quotes from Gabi Heller, @alexholehouse.bsky.social and myself about our shared love of and fascination with these proteins
www.the-scientist.com/the-dynamic-...
Reposted by Seamus Curran
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
November 23, 2024 at 4:00 PM
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
Reposted by Seamus Curran
Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z
This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...
This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...
November 23, 2024 at 6:44 AM
Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z
This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...
This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...