Sean Czerwinski
@sczerwinski.bsky.social
Ph.D. Candidate at GSU with @jamesgurney.bsky.social - Phage researcher that is open to losing a capsid and genome on occasion. Evolutionary medicine in the face of AMR #PhageSteering #HAs
Avid concert goer. Footy fan. Phage phan.
Avid concert goer. Footy fan. Phage phan.
Reposted by Sean Czerwinski
Started / going
Here's a view of Jupiter from NASA's Juno spacecraft, now in orbit there. science.nasa.gov/mission/juno
Image processed from raw data by @kevinmgill.bsky.social
Here's a view of Jupiter from NASA's Juno spacecraft, now in orbit there. science.nasa.gov/mission/juno
Image processed from raw data by @kevinmgill.bsky.social
November 10, 2025 at 9:51 PM
Started / going
Here's a view of Jupiter from NASA's Juno spacecraft, now in orbit there. science.nasa.gov/mission/juno
Image processed from raw data by @kevinmgill.bsky.social
Here's a view of Jupiter from NASA's Juno spacecraft, now in orbit there. science.nasa.gov/mission/juno
Image processed from raw data by @kevinmgill.bsky.social
Reposted by Sean Czerwinski
Happy to see this paper finally out in @pnas.org!
#phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬
Gift link: www.pnas.org/eprint/YYDZ9...
#phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬
Gift link: www.pnas.org/eprint/YYDZ9...
September 8, 2025 at 7:51 PM
Happy to see this paper finally out in @pnas.org!
#phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬
Gift link: www.pnas.org/eprint/YYDZ9...
#phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬
Gift link: www.pnas.org/eprint/YYDZ9...
Reposted by Sean Czerwinski
Happy World Phage Day! Tiny viruses have mighty roles, shaping our environment and life on Earth. Phages maintain microbial community stability, impact primary production, nutrient cycle and pathogen virulence. We can also use phages in phage therapy to combat bacterial infections. #PhageSky
October 22, 2025 at 10:24 AM
Happy World Phage Day! Tiny viruses have mighty roles, shaping our environment and life on Earth. Phages maintain microbial community stability, impact primary production, nutrient cycle and pathogen virulence. We can also use phages in phage therapy to combat bacterial infections. #PhageSky
Reposted by Sean Czerwinski
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway
Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025
www.jobbnorge.no
August 8, 2025 at 7:52 AM
Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Reposted by Sean Czerwinski
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Protein Structure Informed Bacteriophage Genome Annotation with Phold
Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...
www.biorxiv.org
August 8, 2025 at 7:11 AM
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sean Czerwinski
Scientists!
@skypeascientist.bsky.social matches scientists with classrooms, libraries, & more for virtual Q&As! It's easy and fun!
We are looking for 750 more volunteers by 8/15
If you're down to chat with 1-5 classrooms this semester, sign up here
www.skypeascientist.com/sign-up.html
@skypeascientist.bsky.social matches scientists with classrooms, libraries, & more for virtual Q&As! It's easy and fun!
We are looking for 750 more volunteers by 8/15
If you're down to chat with 1-5 classrooms this semester, sign up here
www.skypeascientist.com/sign-up.html
August 7, 2025 at 3:10 PM
Scientists!
@skypeascientist.bsky.social matches scientists with classrooms, libraries, & more for virtual Q&As! It's easy and fun!
We are looking for 750 more volunteers by 8/15
If you're down to chat with 1-5 classrooms this semester, sign up here
www.skypeascientist.com/sign-up.html
@skypeascientist.bsky.social matches scientists with classrooms, libraries, & more for virtual Q&As! It's easy and fun!
We are looking for 750 more volunteers by 8/15
If you're down to chat with 1-5 classrooms this semester, sign up here
www.skypeascientist.com/sign-up.html
Reposted by Sean Czerwinski
Incredible conversations at #ASMicrobe2025! Thank you to everyone who stopped by to talk phages, evolution, and the potential of phage steering in complex infections! @asm.org #PhageSky #PhageSteering
June 23, 2025 at 6:46 PM
Incredible conversations at #ASMicrobe2025! Thank you to everyone who stopped by to talk phages, evolution, and the potential of phage steering in complex infections! @asm.org #PhageSky #PhageSteering
Reposted by Sean Czerwinski
Phage tRNAs: decoding the enigma
Phage tRNAs: decoding the enigma
The presence of tRNAs in bacteriophage genomes has intrigued scientists since their discovery in the early 1960s, as phages were believed to rely on the host tRNAs for their translation. Over the years, a multitude of hypotheses have been explored, providing evidence that phages with different lifestyles utilize tRNAs in distinct ways. In recent years, several studies have provided evidence that phage tRNAs play a crucial role in evading phage defense systems. In this review we summarize the current state of the field of phage tRNAs, highlighting their diverse roles in phage infection. We also discuss the host response to phage tRNAs and the application of this knowledge to improve phage-based therapeutics to combat bacterial infections.
dlvr.it
June 17, 2025 at 11:37 PM
Phage tRNAs: decoding the enigma
Reposted by Sean Czerwinski
Going to ASM Microbe 2025?
Check out the in-depth symposium "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" hosted by Dr. Hernandez (@cathyhernandez.bsky.social) and I!
We have some really cool talks lined up.
Hope to see you there!
🧪🦠🔬
#Phagesky
#Microsky
Check out the in-depth symposium "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" hosted by Dr. Hernandez (@cathyhernandez.bsky.social) and I!
We have some really cool talks lined up.
Hope to see you there!
🧪🦠🔬
#Phagesky
#Microsky
June 16, 2025 at 6:23 PM
Going to ASM Microbe 2025?
Check out the in-depth symposium "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" hosted by Dr. Hernandez (@cathyhernandez.bsky.social) and I!
We have some really cool talks lined up.
Hope to see you there!
🧪🦠🔬
#Phagesky
#Microsky
Check out the in-depth symposium "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" hosted by Dr. Hernandez (@cathyhernandez.bsky.social) and I!
We have some really cool talks lined up.
Hope to see you there!
🧪🦠🔬
#Phagesky
#Microsky
Reposted by Sean Czerwinski
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
It's out! We used the T4P-dependent phage Luz19 to select against the type IV pilus virulence factor in P. aeruginosa, despite the presence of competing S. aureus.
Big day for the Gurney lab, first paper from the lab is now published. @sczerwinski.bsky.social led this work and answered a simple question does phage steering work when other bacteria are around? Tldr: yes! journals.asm.org/doi/epub/10....
Phage steering in the presence of a competing bacterial pathogen
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journals.asm.org
June 10, 2025 at 8:40 PM
It's out! We used the T4P-dependent phage Luz19 to select against the type IV pilus virulence factor in P. aeruginosa, despite the presence of competing S. aureus.
Reposted by Sean Czerwinski
🦑 This baby is COLOSSAL! 🦑
First confirmed live observation of the colossal squid, Mesonychoteuthis hamiltoni, in its natural habitat. Filmed at about 600m near the South Sandwich Islands during the #SouthSandwichIslands expedition. youtu.be/lzPoG9H8Hlo
First confirmed live observation of the colossal squid, Mesonychoteuthis hamiltoni, in its natural habitat. Filmed at about 600m near the South Sandwich Islands during the #SouthSandwichIslands expedition. youtu.be/lzPoG9H8Hlo
Colossal Squid, 1st Live Observation | Searching for New Species in the South Sandwich Islands
YouTube video by Schmidt Ocean
youtu.be
April 15, 2025 at 8:01 PM
🦑 This baby is COLOSSAL! 🦑
First confirmed live observation of the colossal squid, Mesonychoteuthis hamiltoni, in its natural habitat. Filmed at about 600m near the South Sandwich Islands during the #SouthSandwichIslands expedition. youtu.be/lzPoG9H8Hlo
First confirmed live observation of the colossal squid, Mesonychoteuthis hamiltoni, in its natural habitat. Filmed at about 600m near the South Sandwich Islands during the #SouthSandwichIslands expedition. youtu.be/lzPoG9H8Hlo
Reposted by Sean Czerwinski
#NASA's #Chandra X-ray Observatory
Vela Pulsar
chandra.harvard.edu/photo/2013/v...
NASA/CXC/Univ of Toronto/M.Durant/j. Roger
Vela Pulsar
chandra.harvard.edu/photo/2013/v...
NASA/CXC/Univ of Toronto/M.Durant/j. Roger
April 12, 2025 at 5:27 PM
#NASA's #Chandra X-ray Observatory
Vela Pulsar
chandra.harvard.edu/photo/2013/v...
NASA/CXC/Univ of Toronto/M.Durant/j. Roger
Vela Pulsar
chandra.harvard.edu/photo/2013/v...
NASA/CXC/Univ of Toronto/M.Durant/j. Roger
Reposted by Sean Czerwinski
Susan today explains contractile injection systems of Streptomyces
- see their cool paper in @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
#KNVM2025
- see their cool paper in @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
#KNVM2025
Cytoplasmic contractile injection systems mediate cell death in Streptomyces - Nature Microbiology
Characterization of a contractile injection system (CIS) in the Gram-positive multicellular model organism Streptomyces coelicolor finds that CIS mediate cell death in response to stress that impacts ...
www.nature.com
April 2, 2025 at 11:54 AM
Susan today explains contractile injection systems of Streptomyces
- see their cool paper in @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
#KNVM2025
- see their cool paper in @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
#KNVM2025
Reposted by Sean Czerwinski
Fantastic new preprint of Vaughn Cooper's lab @vscooper.micropopbio.org - filamentous phages can get cancer and it's contagious. 🔥👇🏼
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Filamentous cheater phages drive bacterial and phage populations to lower fitness
Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...
www.biorxiv.org
April 2, 2025 at 6:25 AM
Fantastic new preprint of Vaughn Cooper's lab @vscooper.micropopbio.org - filamentous phages can get cancer and it's contagious. 🔥👇🏼
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sean Czerwinski
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology
Genomic and functional analyses of healthcare-associated vancomycin-resistant Enterococcus faecium reveal that bacteriocin T8 is enriched in emergent lineages and provides a competitive advantage in v...
www.nature.com
March 21, 2025 at 1:46 PM
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
Reposted by Sean Czerwinski
Beautiful video of inter-cellular signaling in a swarming response that I pulled from the other place, produced by @strickland-evelyn.bsky.social in collaboration with D. Irimia lab.
The dye detects calcium flux that indicates a signal being received by each cell: you're seeing the 'alarm' go out.
The dye detects calcium flux that indicates a signal being received by each cell: you're seeing the 'alarm' go out.
February 23, 2025 at 3:11 PM
Beautiful video of inter-cellular signaling in a swarming response that I pulled from the other place, produced by @strickland-evelyn.bsky.social in collaboration with D. Irimia lab.
The dye detects calcium flux that indicates a signal being received by each cell: you're seeing the 'alarm' go out.
The dye detects calcium flux that indicates a signal being received by each cell: you're seeing the 'alarm' go out.
Reposted by Sean Czerwinski
Just because its fun~ This is one of my favorite videos I've taken in my PhD! Here is 60x imaging of neutrophils swarming to attack yeast targets in blue :)
November 6, 2024 at 8:34 PM
Just because its fun~ This is one of my favorite videos I've taken in my PhD! Here is 60x imaging of neutrophils swarming to attack yeast targets in blue :)
Reposted by Sean Czerwinski
We developed a microscopy-based technique🔬 to measure attachment of viruses #phages to host cells. 🦠
The paper was posted online today:
www.pnas.org/doi/10.1073/...
#phagesky #microsky
The paper was posted online today:
www.pnas.org/doi/10.1073/...
#phagesky #microsky
December 19, 2024 at 10:10 PM
We developed a microscopy-based technique🔬 to measure attachment of viruses #phages to host cells. 🦠
The paper was posted online today:
www.pnas.org/doi/10.1073/...
#phagesky #microsky
The paper was posted online today:
www.pnas.org/doi/10.1073/...
#phagesky #microsky
Reposted by Sean Czerwinski
I had images in my head of what I wanted to capture on my recent adventure to the southern USA. I wanted storms and sprites with Bayou foregrounds. Man, it is a tough place to chase- dark skies are hard to find as are accessible, treeless areas to get a view.
December 30, 2024 at 7:59 PM
I had images in my head of what I wanted to capture on my recent adventure to the southern USA. I wanted storms and sprites with Bayou foregrounds. Man, it is a tough place to chase- dark skies are hard to find as are accessible, treeless areas to get a view.
Reposted by Sean Czerwinski
Happy to see this out now in @asn-amnat.bsky.social!
We combined experimental evolution and mathematical modeling to ask: can bacteria evolve to swim away from their viral parasites?
1/n #evosky 🦠 #phage 🧪
(gift link:)
www.journals.uchicago.edu/eprint/TETM9...
We combined experimental evolution and mathematical modeling to ask: can bacteria evolve to swim away from their viral parasites?
1/n #evosky 🦠 #phage 🧪
(gift link:)
www.journals.uchicago.edu/eprint/TETM9...
University of Chicago Press Journals: Cookie absent
www.journals.uchicago.edu
December 17, 2024 at 12:52 AM
Happy to see this out now in @asn-amnat.bsky.social!
We combined experimental evolution and mathematical modeling to ask: can bacteria evolve to swim away from their viral parasites?
1/n #evosky 🦠 #phage 🧪
(gift link:)
www.journals.uchicago.edu/eprint/TETM9...
We combined experimental evolution and mathematical modeling to ask: can bacteria evolve to swim away from their viral parasites?
1/n #evosky 🦠 #phage 🧪
(gift link:)
www.journals.uchicago.edu/eprint/TETM9...
Reposted by Sean Czerwinski
Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...
Starter packs
BIOLOGY General Science community https://go.bsky.app/HVYAMEA Research Institutions in Life Sciences https://go.bsky.app/LxXpcvJ LGBTQIA+ in STEM https://go.bsky.app/BFc4wgf LGBTQIA+ in STEM 2 h...
docs.google.com
November 26, 2024 at 2:47 AM
Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...
Is anyone knowledgeable, or knows someone that is, about deciduousness in conifers? I’m curious what were the selective pressure(s) and evolutionary pathways that result in it. I’ve seen a few Tamarack larch (Larix laricina) here in Alaska, they’re amazing!
November 26, 2024 at 8:33 PM
Is anyone knowledgeable, or knows someone that is, about deciduousness in conifers? I’m curious what were the selective pressure(s) and evolutionary pathways that result in it. I’ve seen a few Tamarack larch (Larix laricina) here in Alaska, they’re amazing!