Sarah Melville
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Sarah Melville
@sarahkmels.bsky.social
odd, when I registered for that session last night it said it was on Monday… & I didn’t receive an email after registering to join, 🤔🤷🏼‍♀️
November 19, 2025 at 9:38 PM
Reposted by Sarah Melville
Yes! It can be hard but most folks don't get a lot of symptoms on 0.25 dose. If they go to 0.5 and have issues, go back to 0.25 and go up by "clicks" instead of full dose! See: diabetesjournals.org/care/article...
One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens
Glucagon-like peptide 1 receptor agonists (GLP-1RA) have transformed the landscape of type 2 diabetes and chronic weight management (1). Clinical trials ha
diabetesjournals.org
March 6, 2025 at 12:30 PM
Thanks @shelliefravel.bsky.social for a grrreat #nephjc chat tonight on this big IgAN topic!!, 🤓😀🙏💛
November 19, 2025 at 3:10 AM
Reposted by Sarah Melville
I love this tradition #NephJC
a man in a suit and tie is saying stay classy .
ALT: a man in a suit and tie is saying stay classy .
media.tenor.com
November 19, 2025 at 3:01 AM
Reposted by Sarah Melville
We likely will have to treat IgA patients differently based on their disease timeline. New, flaring patients need upstream treatment, chronic patients that have damage that can’t be unfibrosed need a different therapy plan. There are plenty of patients for all our therapy options. #nephjc
November 19, 2025 at 2:59 AM
Reposted by Sarah Melville
I think Aliza Thompson is an unsung hero in this story for spearheading the albuminuria acceptance at FDA

journals.lww.com/cjasn/pages/...

#NephJC
journals.lww.com
November 19, 2025 at 3:00 AM
wow!, @nephroseeker.medsky.social that's a very great comparison table!!, thank you!, 🤓😀🙏💛
November 19, 2025 at 3:01 AM
Reposted by Sarah Melville
None. HC does not currently accept proteinuria or eGFR slope - this is being worked on. #NephJC
November 19, 2025 at 2:44 AM
Reposted by Sarah Melville
Surrogate markers great for manuscripts but terrible for bragging rights!!
#NephJC
November 19, 2025 at 2:46 AM
am going to mention this information at our IgAN journal club next week!

#nephjc
November 19, 2025 at 2:53 AM
ooh, can you please keep me posted on any potential initiative for that too...? there might be some nephs. here interested in an initiative too

#nephjc
November 19, 2025 at 2:52 AM
ooh, wow!, thanks!, that is interesting to know... seems crazy- HC often seems so far behind in a lot of areas...

#nephjc
November 19, 2025 at 2:46 AM
Reposted by Sarah Melville
November 19, 2025 at 2:37 AM
Reposted by Sarah Melville
This is now a cookie cutter template for all IgA trials

We can copy and paste 🤪

#NephJC
a cartoon penguin is riding a pogo stick on top of a ctrl and v key
Alt: a cartoon penguin is riding a pogo stick on top of a ctrl and v key
media.tenor.com
November 19, 2025 at 2:25 AM
Reposted by Sarah Melville
100% agree

Perfect field for platform trials

My thread on GRACE bsky.app/profile/hswa...

#NephJC
Ongoing late posts from @theisn.org #ISNWCN

from the high impact trial session - this was a great study design

The India ALLIANCE GRACE IgAN trial

Lead by Succeena Alexander from CMC Vellore

#NephSky
1/
November 19, 2025 at 2:39 AM
as learned in the #nephjc IgAN g/l's chat, it should be IgA IgB IgC etc.. but uses Greek alphabet- thread: bsky.app/profile/kidn...
Joel Topf, just out of the shower where I was wondering why it is:
IgG
IgM
IgA
IgE
Rather than
IgA
IgB
IgC
IgD
IgE

#NephJC
November 19, 2025 at 2:40 AM
Are those 4 licensed by Health Canada too?

#nephjc
November 19, 2025 at 2:35 AM
Reposted by Sarah Melville
AFAIK correct. And sibeprenlimab is expected Nov. 28. #NephJC
November 19, 2025 at 2:24 AM