Simone Appenzeller
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sappenzeller.bsky.social
Simone Appenzeller
@sappenzeller.bsky.social
81 followers 110 following 4 posts
Adult and Pediatric Rheumatologist/Medical Education Specialist
Professor of Rheumatology Universidade Estadual de Campinas.
Loves cats/dogs and travel.
Posts Replies Media Videos
Reposted by Simone Appenzeller
rheumnow.bsky.social
Metanalysis of 376 studies, 347 468 pts w/ chronic pain (mean 51yrs; 70%F) finds ~40% had clinically significant depression and anxiety (more common in Women, younger people, pts w nociplastic pain). Depression common in FM (54%) & OA/RA (~28%).
buff.ly
March 10, 2025 at 10:13 PM
Reposted by Simone Appenzeller
nejm.org
The addition of combined oral and topical antimicrobial therapy for male partners to treatment of women for bacterial vaginosis resulted in a lower rate of recurrence within 12 weeks than treatment of the woman alone. Full StepUp trial results and Research Summary: nej.md/3QJIVKn

#MedSky #IDSky
The New England Journal of Medicine Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis A Research Summary based on Vodstrcil LA et al. | 10.1056/NEJMoa2405404 | Published on March 6, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
March 9, 2025 at 7:58 PM
Reposted by Simone Appenzeller
natrevrheum.nature.com
Connecting the structure and function of cartilage using spatial ‘-omics’
Nature Reviews Rheumatology, Published online: 14 February 2025; doi:10.1038/s41584-025-01225-wAdvances in spatial ‘-omics’, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular…
bit.ly
February 16, 2025 at 7:03 PM
Reposted by Simone Appenzeller
vasculitides.bsky.social
Vertebral artery involvement in giant cell arteritis: Symptoms, treatment and outcome
Vertebral artery involvement in giant cell arteritis: Symptoms, treatment and outcome - PubMed
One-third-of patients with cranial GCA were VA+, 19 % of whom had vertebrobasilar stroke, of which most had severe VA occlusive disease. Significant rates of stenosis progression and recurrent stroke ...
pubmed.ncbi.nlm.nih.gov
February 16, 2025 at 5:06 AM
Reposted by Simone Appenzeller
acr-journals.bsky.social
Clinical images in ACR Open Rheumatology
doi.org/10.1002/acr2...
Clinical Images: Back pain, flattened vertebral bodies, and a novel mutation in the TRAPPC2 gene
Click on the article title to read more.
doi.org
February 16, 2025 at 1:42 PM
Reposted by Simone Appenzeller
acr-journals.bsky.social
A 28-year-old man with a 5-year history of progressive hip and back pain was admitted to the clinic. He reported bilateral hip joint pain exacerbated by squatting and standing up. Over time, he developed back pain without morning stiffness
#Medsky #Orthosky
(A)Photograph of the patient showing the generalized body atrophy, short stature, anterior lumbar lordosis and a barrel chest. (B)Spinal radiograph exhibiting thoracolumbar scoliosis. (C)Spinal radiograph demonstrates flattened vertebral bodies, increased horizontal diameter, and central protrusion with concave changes at the anterior upper and lower edges of some vertebrae(red arrow). (D)Gene sequencing of the homozygous frameshift mutation p.Q131Vfs*37 (c.391_392del) in the TRAPPC2 gene within the patient's family.
February 16, 2025 at 1:42 PM
Reposted by Simone Appenzeller
drluiso.bsky.social
If you are an NIH or CDC scientist that lost your job, we have a home for you at UTHealth. I’m hiring physician scientists and we also have transplant ID fellowship slots open. Contact me. #IDSky #MedSky
February 15, 2025 at 11:17 AM
Reposted by Simone Appenzeller
katharinehayhoe.com
Canada’s new Rural Community Immigration Pilot offers permanent residence to skilled workers who want to work and settle in rural and more remote communities.

14 pilot communities will approve certain employers to hire for jobs that they can’t fill with local workers.

More info here:
Rural Community Immigration Pilot - Canada.ca
How to apply for the Rural community immigration pilot as a candidate.
www.canada.ca
February 15, 2025 at 2:39 PM
Reposted by Simone Appenzeller
medicine.stitches.today
Targeting a systolic blood pressure reduction of 55-85 mm Hg within the first two hours improves outcomes in intracerebral hemorrhage patients.

by Li Q, Lv X (...) Goldstein JN et 8 al. in Neurology #MedSky

📖 read the article: https://www.neurology.org/doi/10.1212/WNL.0000000000213412
February 15, 2025 at 2:53 AM
Reposted by Simone Appenzeller
vasculitides.bsky.social
Enhancement within the orbits and superficial temporal artery: MRI clues to the diagnosis of giant cell arteritis
https://pubmed.ncbi.nlm.nih.gov/39931383
Image
February 12, 2025 at 11:17 AM
Reposted by Simone Appenzeller
lupusmadrid.bsky.social
🥺 Malas noticias desde ALUJA Lupus Jaén:

 𝐆𝐮𝐬𝐞𝐥𝐤𝐮𝐦𝐚𝐛, un anticuerpo monoclonal q inhibe la interleucina-23, 𝐧𝐨 𝐬𝐮𝐩𝐞𝐫𝐚 la fase 2 de ensayo clínico para el tratamiento d la nefritis lúpica.

Puedes leer la noticia completa en Medscape
https://t.co/7N1u2SUnA5
February 11, 2025 at 4:42 PM
Reposted by Simone Appenzeller
vasculitides.bsky.social
The giant cell arteritis (GCA) ultrasound score (OGUS) at diagnosis and after initial treatment predicts future relapses in GCA patients: results of a multicentre prospective study
The giant cell arteritis (GCA) ultrasound score (OGUS) at diagnosis and after initial treatment predicts future relapses in GCA patients: results of a multicentre prospective study - PubMed
Ultrasonography has a prognostic role in GCA and can inform risk stratification. Higher OGUS at diagnosis is associated with relapse, while a higher degree and rapidity of improvement in the first wee...
pubmed.ncbi.nlm.nih.gov
February 11, 2025 at 5:25 AM
Reposted by Simone Appenzeller
jama.com
A clinical decision support system from the European Society of Radiology did not reduce the number of inappropriate imaging requests ordered by physicians in academic hospital settings.

ja.ma/3WNquIs

#MedSky
Figure 2. Imaging Request Change Matrix
February 10, 2025 at 8:46 PM
Reposted by Simone Appenzeller
nejm.org
Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh

#MedSky #Nephrology
Iptacopan in IgA Nephropathy A Research Summary based on Perkovic V et al. | 10.1056/NEJMoa2410316 | Published on October 25, 2024
February 10, 2025 at 8:45 PM
Reposted by Simone Appenzeller
jama.com
This Viewpoint discusses recommendations to rethink and redesign the use of race and ethnicity in biomedical research and provides steps to facilitate the process.

ja.ma/413ZDdB

#MedSky #MedEd
Figure. Considerations for Use of Race and Ethnicity in Research
February 10, 2025 at 9:15 PM
Reposted by Simone Appenzeller
vasculitides.bsky.social
OMERACT GCA phantom project: validation of a 3D-printed ultrasound training phantom for diagnosis of giant cell arteritis
OMERACT GCA phantom project: validation of a 3D-printed ultrasound training phantom for diagnosis of giant cell arteritis - PubMed
The study demonstrated high reliability among ultrasound experts in applying the OMERACT ultrasound definitions for GCA and in measuring the IMT using a 3D-printed phantom of the AA and TA. This phant...
pubmed.ncbi.nlm.nih.gov
February 9, 2025 at 2:40 AM
Reposted by Simone Appenzeller
folha.com
O que fazer após alcançar um objetivo sem se desmotivar
Você alcançou seu objetivo. E agora?
Sentir-se desmotivado após uma conquista é normal; saiba como lidar com isso sem perder o ânimo
www1.folha.uol.com.br
February 9, 2025 at 6:42 PM
Reposted by Simone Appenzeller
lupusencyclopedia.bsky.social
Broken bones is a common complication in #lupus #SLE patients. Steroids are among the top causes. However, the inflammation from lupus most likely also plays a role. Fractures can be prevented: www.lupusencyclopedia.com/bisphosphona...
Bisphosphonate Drugs and Lupus
Live Longer and Better with Lupus! Whether you are a lupus patient seeking practical, easy to understand tips, or a healthcare provider wanting to treat your patients better, The Lupus Encyclopedia pr...
www.lupusencyclopedia.com
February 9, 2025 at 6:10 PM
Reposted by Simone Appenzeller
boghuma.bsky.social
TB is a disease of poverty
A new RCT in @thelancetinfdis.bsky.social shows that pre-test & post-test TB counseling + conditional cash transfers significantly improved treatment outcomes in South Africa. The intervention cut unsuccessful TB outcomes nearly in half!
www.thelancet.com/journals/lan...
Effects of conditional cash transfers and pre-test and post-test tuberculosis counselling on patient outcomes and loss to follow-up across the continuum of care in South Africa: a randomised controlle...
The package of interventions consisting of pre-test and post-test tuberculosis counselling with conditional cash transfers significantly reduced the risk of unsuccessful tuberculosis patient outcomes,...
www.thelancet.com
February 9, 2025 at 2:02 PM
Reposted by Simone Appenzeller
lupusencyclopedia.bsky.social
Some #SLE #lupus #Sjogrens patients can have mottled skin. Most of the time it is not dangerous. Other times, it may need treatment, depending on the cause: www.lupusencyclopedia.com/lupus-mottle...
Lupus Mottled Skin and the Symptoms (February 2025 Update)
Live Longer and Better with Lupus! Whether you are a lupus patient seeking practical, easy to understand tips, or a healthcare provider wanting to treat your patients better, The Lupus Encyclopedia pr...
www.lupusencyclopedia.com
February 9, 2025 at 7:53 PM
Reposted by Simone Appenzeller
nejm.org
A 𝗻𝗲𝘂𝗿𝗮𝗹 𝗰𝗿𝗲𝘀𝘁 is a group of ectodermal cells that are pinched off during neural tube closure. The neural crest migrates to various locations to contribute to diverse tissues, including melanocytes, craniofacial bones, and peripheral-nerve ganglia.

#MedSky #ScienceSky
Visual representation of "neural crest."
February 8, 2025 at 9:15 PM
Reposted by Simone Appenzeller
jama.com
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Society of Critical Care Medicine guidelines on use of corticosteroids in sepsis, acute respiratory distress syndrome, and community-acquired pneumonia.

ja.ma/4hL4Kou

#MedSky #MedEd
Preview of PDF.
February 8, 2025 at 7:50 PM
Reposted by Simone Appenzeller
medicine.stitches.today
Hypoxia-induced pulmonary hypertension is driven by interstitial macrophages, revealing potential therapeutic targets for treatment.

by Kumar R, Nolan K (...) Graham BB et 20 al. in J Clin Invest #MedSky

📖 read the article: https://www.jci.org/articles/view/176865
February 8, 2025 at 2:51 AM
Reposted by Simone Appenzeller
lupusencyclopedia.bsky.social
Did you know that #SLE #lupus can cause hives for nonallergic reasons?
www.lupusencyclopedia.com/lupus-and-hi...
Lupus and Hives
Live Longer and Better with Lupus! Whether you are a lupus patient seeking practical, easy to understand tips, or a healthcare provider wanting to treat your patients better, The Lupus Encyclopedia pr...
www.lupusencyclopedia.com
February 8, 2025 at 9:45 PM
Reposted by Simone Appenzeller
lupusencyclopedia.bsky.social
It is that time of year (Winter in the Northern Hemisphere) when dry, itchy skin worsens. #SLE #lupus patients often get #Sjogrens, which causes dryness. Knowing healthy skin habits & which soaps are best for have active cutaneous lupus lesions is important www.lupusencyclopedia.com/the-best-soa...
The Best Soap for Lupus Patients (February 2025 Update)
Live Longer and Better with Lupus! Whether you are a lupus patient seeking practical, easy to understand tips, or a healthcare provider wanting to treat your patients better, The Lupus Encyclopedia pr...
www.lupusencyclopedia.com
February 9, 2025 at 12:18 AM