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PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com

Nature Reviews Genetics, Published online: 11 April 2025; doi:10.1038/s41576-025-00836-zPost-transcriptional splicing has emerged as a key layer of gene expression regulation but is challenging to differentiate from co-transcriptional splicing. The authors review methodologies to detect post-transcriptional splicing, the mechanisms controlling splicing timing and how the temporal regulation of splicing affects gene expression.

Inaccuracies in RNA splicing may play a significant role in aging and disease. Here, the authors present a comprehensive characterization of splicing accuracy across over 14,000 human samples, offerin...

This Review describes how increasingly sophisticated omics data and computational models of the splicing code are paving the way to more accurate, context-specific splicing predictions, while also pro...

This analysis provides 108 noncoding CRISPR screens collated by the ENCODE4 consortium and establishes experimental guidelines for future CRISPRi screens characterizing functional cis-regulatory eleme...