New year new start! My group has moved to the Dept of Biosystems Science and Engineering in ETH Zurich - very excited to work with new colleagues here! We’re also hiring soon, if interested in a PhD/postdoc in quantitative genetics and genomics, esp with focus in psych disorders, pls get in touch!

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?

I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos

Among pregnant/postpartum persons who received unusual/unreportable cfDNA for fetal aneuploidy, 1 in 2 had occult cancer! Most variants were CNVs across multiple chromosomes www.nejm.org/doi/full/10....

Finally my startup to do point-of-meal sequence verification of fish cuts has a name.

Fillet MinION

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.

Our paper: A comprehensive overview of neuropsychiatric symptoms in adolescents with 22q11.2 deletion syndrome, highlights the importance of looking beyond labels in psychiatry.
The majority of our cohort (n=208) experience mental health symptoms across various domains.

doi.org/10.1111/jir....