Rui Santalla
@ruisantalla.bsky.social
PhD student | Immunology, cancer and TME.
ESR at MSCA Evomet ITN and @joycelab.bsky.social @unil.bsky.social 🧪🧬
ESR at MSCA Evomet ITN and @joycelab.bsky.social @unil.bsky.social 🧪🧬
Reposted by Rui Santalla
Celebrating our annual international lab dinner 🎉 👨🏽🍳 🧑🏻🍳
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
September 25, 2025 at 1:46 PM
Celebrating our annual international lab dinner 🎉 👨🏽🍳 🧑🏻🍳
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
Reposted by Rui Santalla
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
September 3, 2025 at 12:56 PM
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Reposted by Rui Santalla
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
August 14, 2025 at 6:35 PM
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
Reposted by Rui Santalla
Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), please reach out if you know someone interested!
July 16, 2025 at 7:19 AM
Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), please reach out if you know someone interested!
Beyond the (v cool) paper itself, I am intrigued by a few facts:
- 80% (!!!) of never-smoker lung cancer patients are women. Are the molecular mechanisms driving this susceptibility known?
- First time I read about aristolochic acid– in which plants is this compound present? What are these used for?
- 80% (!!!) of never-smoker lung cancer patients are women. Are the molecular mechanisms driving this susceptibility known?
- First time I read about aristolochic acid– in which plants is this compound present? What are these used for?
Nature research paper: The mutagenic forces shaping the genomes of lung cancer in never smokers
go.nature.com/4l5HkfD
go.nature.com/4l5HkfD
The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature
An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.
go.nature.com
July 10, 2025 at 3:41 PM
Beyond the (v cool) paper itself, I am intrigued by a few facts:
- 80% (!!!) of never-smoker lung cancer patients are women. Are the molecular mechanisms driving this susceptibility known?
- First time I read about aristolochic acid– in which plants is this compound present? What are these used for?
- 80% (!!!) of never-smoker lung cancer patients are women. Are the molecular mechanisms driving this susceptibility known?
- First time I read about aristolochic acid– in which plants is this compound present? What are these used for?
I never thought this was even possible. I have a thousand questions and a few concerns. Fascinating.
In vivo CAR T cell generation to treat cancer and autoimmune disease | Science www.science.org/doi/10.1126/...
In vivo CAR T cell generation to treat cancer and autoimmune disease
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...
www.science.org
June 20, 2025 at 8:40 AM
I never thought this was even possible. I have a thousand questions and a few concerns. Fascinating.
Reposted by Rui Santalla
Celebrating 2️⃣0️⃣ years of the Joyce Lab 🎉
We had an amazing reunion, bringing together past & present lab members from Lausanne & NYC 🏔️🗽
Huge thanks to everyone who came from around the world, shared science & happy memories and together made this milestone really special 😍
#JoyceLab20 #ProudMentor
We had an amazing reunion, bringing together past & present lab members from Lausanne & NYC 🏔️🗽
Huge thanks to everyone who came from around the world, shared science & happy memories and together made this milestone really special 😍
#JoyceLab20 #ProudMentor
June 11, 2025 at 2:05 PM
Celebrating 2️⃣0️⃣ years of the Joyce Lab 🎉
We had an amazing reunion, bringing together past & present lab members from Lausanne & NYC 🏔️🗽
Huge thanks to everyone who came from around the world, shared science & happy memories and together made this milestone really special 😍
#JoyceLab20 #ProudMentor
We had an amazing reunion, bringing together past & present lab members from Lausanne & NYC 🏔️🗽
Huge thanks to everyone who came from around the world, shared science & happy memories and together made this milestone really special 😍
#JoyceLab20 #ProudMentor
Reposted by Rui Santalla
Wishing our amazing postdoc @lbejarano.bsky.social continued success and happiness - as she leaves us to start her own lab in Spain 🎉🥳
Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!
#NewPI 🤩
#ProudMentor 😊
Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!
#NewPI 🤩
#ProudMentor 😊
May 27, 2025 at 6:07 PM
Wishing our amazing postdoc @lbejarano.bsky.social continued success and happiness - as she leaves us to start her own lab in Spain 🎉🥳
Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!
#NewPI 🤩
#ProudMentor 😊
Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!
#NewPI 🤩
#ProudMentor 😊
Reposted by Rui Santalla
Congratulations to @annagavrilenko.bsky.social, a wonderful scientist in our lab for successfully defending her master's thesis on brain metastasis & completing her MSc degree with flying colours at @unil.bsky.social 🤩🎉
Special thanks also to @ruisantalla.bsky.social her super MSc lab supervisor 🙏
Special thanks also to @ruisantalla.bsky.social her super MSc lab supervisor 🙏
April 8, 2025 at 11:01 AM
Congratulations to @annagavrilenko.bsky.social, a wonderful scientist in our lab for successfully defending her master's thesis on brain metastasis & completing her MSc degree with flying colours at @unil.bsky.social 🤩🎉
Special thanks also to @ruisantalla.bsky.social her super MSc lab supervisor 🙏
Special thanks also to @ruisantalla.bsky.social her super MSc lab supervisor 🙏
Reposted by Rui Santalla
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
March 31, 2025 at 12:20 PM
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
🧵 1/
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Reposted by Rui Santalla
It’s just bad news all the time now.
February 24, 2025 at 11:11 PM
It’s just bad news all the time now.
Reposted by Rui Santalla
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
scim.ag
February 24, 2025 at 2:59 PM
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
Reposted by Rui Santalla
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.
https://go.nature.com/43ao2zq
https://go.nature.com/43ao2zq
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
go.nature.com
February 24, 2025 at 9:39 PM
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.
https://go.nature.com/43ao2zq
https://go.nature.com/43ao2zq
Reposted by Rui Santalla
Excited to share a new paper from our lab 😀
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
February 10, 2025 at 2:03 PM
Excited to share a new paper from our lab 😀
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪
So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠?
Massara et al 2025
www.cell.com/iscience/ful...
Reposted by Rui Santalla
Devastating for scientists and their research, and everyone who benefits from that research.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research.
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 11:24 PM
Devastating for scientists and their research, and everyone who benefits from that research.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
Reposted by Rui Santalla
Celebrating the start of the holiday season with our wonderful lab 🎄🎅 🎁
Grateful for this incredible, fun team - and a great year of science together 🤩🙏
Happy holidays!! 🌟🥂❄️🎉
Grateful for this incredible, fun team - and a great year of science together 🤩🙏
Happy holidays!! 🌟🥂❄️🎉
December 9, 2024 at 8:57 AM
Celebrating the start of the holiday season with our wonderful lab 🎄🎅 🎁
Grateful for this incredible, fun team - and a great year of science together 🤩🙏
Happy holidays!! 🌟🥂❄️🎉
Grateful for this incredible, fun team - and a great year of science together 🤩🙏
Happy holidays!! 🌟🥂❄️🎉
Jacco came to Lausanne a few months ago and presented this beautiful story from his lab. I love the additional layer of complexity regarding biological cycles in cancer, beyond (now more common) circadian rhythms
"The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy"
🧪
www.nature.com/articles/s41...
🧪
www.nature.com/articles/s41...
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy - Nature
In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus s...
www.nature.com
December 4, 2024 at 5:03 PM
Jacco came to Lausanne a few months ago and presented this beautiful story from his lab. I love the additional layer of complexity regarding biological cycles in cancer, beyond (now more common) circadian rhythms