Johanna Joyce Lab
@joycelab.bsky.social
We are dedicated to understanding and ultimately helping treat cancer
Led by @johannajoyce.bsky.social
@unil.bsky.social, @ludwigcancer.bsky.social, @fbm-unil.bsky.social
www.joycelab.org; https://agora-cancer.ch/laboratory/joyce-lab/
Led by @johannajoyce.bsky.social
@unil.bsky.social, @ludwigcancer.bsky.social, @fbm-unil.bsky.social
www.joycelab.org; https://agora-cancer.ch/laboratory/joyce-lab/
Pinned
Johanna Joyce Lab
@joycelab.bsky.social
· Nov 17
Hi friends 👋
We are a lab of curious researchers - dedicated to understanding and ultimately helping treat cancer
Our lab is led by Johanna Joyce, and we are students, postdocs & technicians from all over the world
🇮🇪🇨🇭🇪🇸🇫🇷🇵🇹🇮🇹🇨🇦🇲🇽🇪🇬🇬🇧🇩🇪
We love doing science 🧪🔬 and living in beautiful Lausanne, Switzerland!
We are a lab of curious researchers - dedicated to understanding and ultimately helping treat cancer
Our lab is led by Johanna Joyce, and we are students, postdocs & technicians from all over the world
🇮🇪🇨🇭🇪🇸🇫🇷🇵🇹🇮🇹🇨🇦🇲🇽🇪🇬🇬🇧🇩🇪
We love doing science 🧪🔬 and living in beautiful Lausanne, Switzerland!
Reposted by Johanna Joyce Lab
Wonderful kick-off meeting this week in Barcelona for our new @adaptmet.bsky.social PhD ITN!
So inspiring to meet our 16 new PhD students, welcome new PIs and reconnect with friends from Evomet ITN - a true celebration of diversity and excellence in #metastasis research across Europe 🙌
adaptmet.eu
So inspiring to meet our 16 new PhD students, welcome new PIs and reconnect with friends from Evomet ITN - a true celebration of diversity and excellence in #metastasis research across Europe 🙌
adaptmet.eu
November 14, 2025 at 12:27 PM
Wonderful kick-off meeting this week in Barcelona for our new @adaptmet.bsky.social PhD ITN!
So inspiring to meet our 16 new PhD students, welcome new PIs and reconnect with friends from Evomet ITN - a true celebration of diversity and excellence in #metastasis research across Europe 🙌
adaptmet.eu
So inspiring to meet our 16 new PhD students, welcome new PIs and reconnect with friends from Evomet ITN - a true celebration of diversity and excellence in #metastasis research across Europe 🙌
adaptmet.eu
Reposted by Johanna Joyce Lab
Join us behind the scenes at the EACR Congress!
Go inside the decision-making process - how the programme comes together, what the committee looks for in cutting-edge science, and how the meeting sparks the next big ideas in cancer research.
magazine.eacr.org/behind-the-s...
Go inside the decision-making process - how the programme comes together, what the committee looks for in cutting-edge science, and how the meeting sparks the next big ideas in cancer research.
magazine.eacr.org/behind-the-s...
Behind the scenes at the EACR Congress - Episode 26 of The Cancer Researcher Podcast - The Cancer Researcher
In this episode, we go behind the scenes of the Annual Congress of the European Association for Cancer Research, a four day congress dedicated to basic, preclinical and translational cancer research…
magazine.eacr.org
November 12, 2025 at 10:01 AM
Join us behind the scenes at the EACR Congress!
Go inside the decision-making process - how the programme comes together, what the committee looks for in cutting-edge science, and how the meeting sparks the next big ideas in cancer research.
magazine.eacr.org/behind-the-s...
Go inside the decision-making process - how the programme comes together, what the committee looks for in cutting-edge science, and how the meeting sparks the next big ideas in cancer research.
magazine.eacr.org/behind-the-s...
Reposted by Johanna Joyce Lab
Honored to be among the #HighlyCited2025 researchers - which is truly a testament to the brilliant, dedicated scientists in my lab, and our many generous collaborators in Lausanne and beyond 🙏
@fbm-unil.bsky.social
@unil.bsky.social
@ludwigcancer.bsky.social
clarivate.com/highly-cited...
@fbm-unil.bsky.social
@unil.bsky.social
@ludwigcancer.bsky.social
clarivate.com/highly-cited...
Clarivate Highly Cited Researchers 2025
The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...
clarivate.com
November 12, 2025 at 2:01 PM
Honored to be among the #HighlyCited2025 researchers - which is truly a testament to the brilliant, dedicated scientists in my lab, and our many generous collaborators in Lausanne and beyond 🙏
@fbm-unil.bsky.social
@unil.bsky.social
@ludwigcancer.bsky.social
clarivate.com/highly-cited...
@fbm-unil.bsky.social
@unil.bsky.social
@ludwigcancer.bsky.social
clarivate.com/highly-cited...
Reposted by Johanna Joyce Lab
💡 A new study in @cp-iscience.bsky.social led by @johannajoyce.bsky.social (@fbm-unil.bsky.social @unil.bsky.social @ludwigcancer.bsky.social) & Jean Hausser (@scilifelab.se @ki.se) tracks how #breast #tumors change over time, cell by cell.
➡️ www.unil.ch/news/1762789...
➡️ www.unil.ch/news/1762789...
Time in the tumor: how cancer and immunity evolve together
By tracking thousands of cells over time, a study in iScience from Johanna Joyce and Jean Hausser exposes how cancer and immunity evolve together and where therapy might strike most effectively. This ...
www.unil.ch
November 11, 2025 at 10:57 AM
💡 A new study in @cp-iscience.bsky.social led by @johannajoyce.bsky.social (@fbm-unil.bsky.social @unil.bsky.social @ludwigcancer.bsky.social) & Jean Hausser (@scilifelab.se @ki.se) tracks how #breast #tumors change over time, cell by cell.
➡️ www.unil.ch/news/1762789...
➡️ www.unil.ch/news/1762789...
Reposted by Johanna Joyce Lab
How does the tumor microenvironment change as cancer progresses - & which cells appear, persist, or disappear along the way?
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Study reveals dynamics of breast tumor microenvironment over time | Johanna Joyce posted on the topic | LinkedIn
How does the tumor microenvironment change as cancer progresses — and which cells appear, persist, or disappear along the way?
In this new study, a wonderful collaboration with Jean Hausser and his l...
www.linkedin.com
November 10, 2025 at 3:06 PM
How does the tumor microenvironment change as cancer progresses - & which cells appear, persist, or disappear along the way?
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Reposted by Johanna Joyce Lab
Researchers led by Ludwig @unil.bsky.social’s @johannajoyce.bsky.social, Spenser Watson and alumnus Jean Hausser have captured the temporal cellular dynamics of the tumor microenvironment over four weeks following tumor induction in a mouse model of breast cancer. bit.ly/4nCzA59
#CanSky #OncoSky
#CanSky #OncoSky
November 10, 2025 at 2:59 PM
Researchers led by Ludwig @unil.bsky.social’s @johannajoyce.bsky.social, Spenser Watson and alumnus Jean Hausser have captured the temporal cellular dynamics of the tumor microenvironment over four weeks following tumor induction in a mouse model of breast cancer. bit.ly/4nCzA59
#CanSky #OncoSky
#CanSky #OncoSky
Reposted by Johanna Joyce Lab
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr
#tumorbiology
#tumorbiology
November 5, 2025 at 12:12 PM
Could understanding how #cancer cells talk to their neighbours help stop the disease? Johanna Joyce, a regular at #VIBConf, will uncover these new ways to predict, prevent, and treat cancer. Join #THPT25 before 26 Nov and decode the therapies that outsmart cancer: vibbio.tech/3Le9oAr
#tumorbiology
#tumorbiology
Reposted by Johanna Joyce Lab
Love our university campus in autumn 🍂🧡♥️
October 14, 2025 at 5:19 PM
Love our university campus in autumn 🍂🧡♥️
Reposted by Johanna Joyce Lab
The Mark Foundation for Cancer Research is making a huge impact - in the US and globally 🙌
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
$34.5 million in awarded grants. 7 new interventional trials. 212 peer-reviewed publications. Read our newly released 2024 Annual Report to catch up on our grantees’ achievements and discover how we’re accelerating progress in the fight against cancer.
2024.themarkfoundation.org
2024.themarkfoundation.org
October 7, 2025 at 8:43 PM
The Mark Foundation for Cancer Research is making a huge impact - in the US and globally 🙌
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
Reposted by Johanna Joyce Lab
Delighted to join the annual #ASEICA cancer research congress in Bilbao 🇪🇸
An exciting agenda sharing our team's science in the opening keynote on Oct 8, joining a "Meet the Expert" on Wed evening, and the "Women Leading Science" roundtable Oct 9 lunchtime
@aseica.bsky.social @helloeacr.bsky.social
An exciting agenda sharing our team's science in the opening keynote on Oct 8, joining a "Meet the Expert" on Wed evening, and the "Women Leading Science" roundtable Oct 9 lunchtime
@aseica.bsky.social @helloeacr.bsky.social
Join us next Thursday in the ASEICA woman round table with two inspirational women in science #AnaJanic and @johannajoyce.bsky.social at the 20th ASEICA Congress in Bilbao! @aseica.bsky.social @nuriaferrandiz.bsky.social
October 3, 2025 at 4:08 PM
Delighted to join the annual #ASEICA cancer research congress in Bilbao 🇪🇸
An exciting agenda sharing our team's science in the opening keynote on Oct 8, joining a "Meet the Expert" on Wed evening, and the "Women Leading Science" roundtable Oct 9 lunchtime
@aseica.bsky.social @helloeacr.bsky.social
An exciting agenda sharing our team's science in the opening keynote on Oct 8, joining a "Meet the Expert" on Wed evening, and the "Women Leading Science" roundtable Oct 9 lunchtime
@aseica.bsky.social @helloeacr.bsky.social
Reposted by Johanna Joyce Lab
Celebrating our annual international lab dinner 🎉 👨🏽🍳 🧑🏻🍳
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
September 25, 2025 at 1:46 PM
Celebrating our annual international lab dinner 🎉 👨🏽🍳 🧑🏻🍳
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏
Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
Reposted by Johanna Joyce Lab
A team led by Ludwig Lausanne’s @johannajoyce.bsky.social & former postdoc @alvarezprado.bsky.social reports a potential drug target whose loss in certain GBM cells triggers antiviral alarms to stall cell proliferation & makes GBM tumors in mice more amenable to anti-cancer immunity.
bit.ly/4nhZ7Bj
bit.ly/4nhZ7Bj
September 23, 2025 at 5:21 PM
A team led by Ludwig Lausanne’s @johannajoyce.bsky.social & former postdoc @alvarezprado.bsky.social reports a potential drug target whose loss in certain GBM cells triggers antiviral alarms to stall cell proliferation & makes GBM tumors in mice more amenable to anti-cancer immunity.
bit.ly/4nhZ7Bj
bit.ly/4nhZ7Bj
Reposted by Johanna Joyce Lab
A pleasure to speak at the amazing #ImmunoRad meeting in the heart of Paris, at the beautiful Sorbonne Université, and to share the research of our wonderful team!
Many thanks to all the organisers for such a stimulating conference at the intersection of #cancer #radiotherapy and #immunity 🙏 ☢️⚕️🧪🔬
Many thanks to all the organisers for such a stimulating conference at the intersection of #cancer #radiotherapy and #immunity 🙏 ☢️⚕️🧪🔬
"Unraveling the complexity of cancer ecosystems following therapeutic intervention" from Pr Johanna Joyce in the "Immunosuppression" session.
Highlights of the talk on Linkedin➡️ www.linkedin.com/feed/update/...
Highlights of the talk on Linkedin➡️ www.linkedin.com/feed/update/...
September 18, 2025 at 12:19 PM
A pleasure to speak at the amazing #ImmunoRad meeting in the heart of Paris, at the beautiful Sorbonne Université, and to share the research of our wonderful team!
Many thanks to all the organisers for such a stimulating conference at the intersection of #cancer #radiotherapy and #immunity 🙏 ☢️⚕️🧪🔬
Many thanks to all the organisers for such a stimulating conference at the intersection of #cancer #radiotherapy and #immunity 🙏 ☢️⚕️🧪🔬
Reposted by Johanna Joyce Lab
Dear friends at the University of Lausanne - please consider signing this petition
This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼🎓 - and have a knock-on effect on the local economy
All students, staff, faculty can sign ⏬
This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼🎓 - and have a knock-on effect on the local economy
All students, staff, faculty can sign ⏬
Let’s reject budget cuts in education and research!
We, researchers, students, and members of the administrative and technical staff of
the University of Lausanne (UNIL), firmly oppose the budget cuts announced for
UNIL by the government of Vaud on 24t...
vaud.ssp-vpod.ch
September 12, 2025 at 1:58 PM
Dear friends at the University of Lausanne - please consider signing this petition
This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼🎓 - and have a knock-on effect on the local economy
All students, staff, faculty can sign ⏬
This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼🎓 - and have a knock-on effect on the local economy
All students, staff, faculty can sign ⏬
A warm welcome to our new lab members!
Matteo Poncina 🇮🇹 starting his PhD in the Adaptmet ITN
Inés Panigua Cabana 🇪🇸 joining us for her postdoc
Alessandro Gigliotti 🇨🇭 & Juan Daniel Martin del Campo Flores 🇲🇽 doing their master thesis research with us
Looking forward to exciting science together 🙌 🧪
Matteo Poncina 🇮🇹 starting his PhD in the Adaptmet ITN
Inés Panigua Cabana 🇪🇸 joining us for her postdoc
Alessandro Gigliotti 🇨🇭 & Juan Daniel Martin del Campo Flores 🇲🇽 doing their master thesis research with us
Looking forward to exciting science together 🙌 🧪
September 10, 2025 at 9:35 AM
A warm welcome to our new lab members!
Matteo Poncina 🇮🇹 starting his PhD in the Adaptmet ITN
Inés Panigua Cabana 🇪🇸 joining us for her postdoc
Alessandro Gigliotti 🇨🇭 & Juan Daniel Martin del Campo Flores 🇲🇽 doing their master thesis research with us
Looking forward to exciting science together 🙌 🧪
Matteo Poncina 🇮🇹 starting his PhD in the Adaptmet ITN
Inés Panigua Cabana 🇪🇸 joining us for her postdoc
Alessandro Gigliotti 🇨🇭 & Juan Daniel Martin del Campo Flores 🇲🇽 doing their master thesis research with us
Looking forward to exciting science together 🙌 🧪
Reposted by Johanna Joyce Lab
𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄: 𝐅𝐥𝐢𝐩𝐩𝐢𝐧𝐠 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐠𝐥𝐢𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚
#BrainTIME 🧠🦠🔬🧪
UNIL news 📰: www.unil.ch/news/1757312...
#OpenAccess article 🔗: www.sciencedirect.com/science/arti...
@alvarezprado.bsky.social @ahernandezb.bsky.social
@joycelab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
#BrainTIME 🧠🦠🔬🧪
UNIL news 📰: www.unil.ch/news/1757312...
#OpenAccess article 🔗: www.sciencedirect.com/science/arti...
@alvarezprado.bsky.social @ahernandezb.bsky.social
@joycelab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
#adar1 #adar1 | Oncologie | UNIL-CHUV
𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄: 𝐅𝐥𝐢𝐩𝐩𝐢𝐧𝐠 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐠𝐥𝐢𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚
🧠 Glioblastoma is one of the deadliest cancers. A new study in 𝑪𝒆𝒍𝒍 𝑹𝒆𝒑𝒐𝒓𝒕𝒔 by Ángel Álvarez-Prado and Johanna Joyce shows how reawakenin...
www.linkedin.com
September 8, 2025 at 5:33 PM
𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄: 𝐅𝐥𝐢𝐩𝐩𝐢𝐧𝐠 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐠𝐥𝐢𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚
#BrainTIME 🧠🦠🔬🧪
UNIL news 📰: www.unil.ch/news/1757312...
#OpenAccess article 🔗: www.sciencedirect.com/science/arti...
@alvarezprado.bsky.social @ahernandezb.bsky.social
@joycelab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
#BrainTIME 🧠🦠🔬🧪
UNIL news 📰: www.unil.ch/news/1757312...
#OpenAccess article 🔗: www.sciencedirect.com/science/arti...
@alvarezprado.bsky.social @ahernandezb.bsky.social
@joycelab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
Reposted by Johanna Joyce Lab
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Álvarez-Prado et al. report that targeting ADAR1 triggers cancer-cell-intrinsic anti-proliferative mechanisms and fosters anti-tumoral immune responses, blocking tumor growth and extending survival in preclinical mouse models of glioblastoma.
dlvr.it
September 8, 2025 at 2:38 PM
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Reposted by Johanna Joyce Lab
Congratulations to all the ERC Starting Grant awardees 🧪 including @alvarezprado.bsky.social & @lbejarano.bsky.social, two brilliant former postdocs from my lab who have started their own labs this year in 🇱🇺 and 🇪🇸
Could not be more proud of Leire and Ángel 🤩 🎉 🎉 🎉
#proudmentor 😊
#ERCStartingGrant
Could not be more proud of Leire and Ángel 🤩 🎉 🎉 🎉
#proudmentor 😊
#ERCStartingGrant
September 4, 2025 at 12:18 PM
Congratulations to all the ERC Starting Grant awardees 🧪 including @alvarezprado.bsky.social & @lbejarano.bsky.social, two brilliant former postdocs from my lab who have started their own labs this year in 🇱🇺 and 🇪🇸
Could not be more proud of Leire and Ángel 🤩 🎉 🎉 🎉
#proudmentor 😊
#ERCStartingGrant
Could not be more proud of Leire and Ángel 🤩 🎉 🎉 🎉
#proudmentor 😊
#ERCStartingGrant
Reposted by Johanna Joyce Lab
Thrilled to share that I’ve been awarded an ERC Starting Grant for the METAVASC project, focused on studying the vasculature in brain mets 🙏🎉
Huge thanks to the ERC, mentors & collaborators that made this possible!
We’ll soon recruit PhDs, postdocs & techs, stay tuned😊
@erc.europa.eu #ERCStG
Huge thanks to the ERC, mentors & collaborators that made this possible!
We’ll soon recruit PhDs, postdocs & techs, stay tuned😊
@erc.europa.eu #ERCStG
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 12:50 PM
Thrilled to share that I’ve been awarded an ERC Starting Grant for the METAVASC project, focused on studying the vasculature in brain mets 🙏🎉
Huge thanks to the ERC, mentors & collaborators that made this possible!
We’ll soon recruit PhDs, postdocs & techs, stay tuned😊
@erc.europa.eu #ERCStG
Huge thanks to the ERC, mentors & collaborators that made this possible!
We’ll soon recruit PhDs, postdocs & techs, stay tuned😊
@erc.europa.eu #ERCStG
Reposted by Johanna Joyce Lab
I’m beyond thrilled to announce that we’ve been awarded the ERC Starting Grant! 🥳🥳🥳
This exceptional support will let us look into how ageing and genetic variation shape responses to therapy against brain metastatic tumors 🧠
Let’s go! 🤩
#ERCStG #Ageing #Immunogenomics #BrainMetastasis
This exceptional support will let us look into how ageing and genetic variation shape responses to therapy against brain metastatic tumors 🧠
Let’s go! 🤩
#ERCStG #Ageing #Immunogenomics #BrainMetastasis
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 10:41 AM
I’m beyond thrilled to announce that we’ve been awarded the ERC Starting Grant! 🥳🥳🥳
This exceptional support will let us look into how ageing and genetic variation shape responses to therapy against brain metastatic tumors 🧠
Let’s go! 🤩
#ERCStG #Ageing #Immunogenomics #BrainMetastasis
This exceptional support will let us look into how ageing and genetic variation shape responses to therapy against brain metastatic tumors 🧠
Let’s go! 🤩
#ERCStG #Ageing #Immunogenomics #BrainMetastasis
Reposted by Johanna Joyce Lab
Thrilled to share our new study from @joycelab.bsky.social on glioblastoma, the most aggressive brain tumor. Targeting ADAR1 slows tumor growth & mobilizes the immune system — a step forward for future treatments. www.sciencedirect.com/science/arti... 🔗 1/3
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Glioblastomas are the most frequent and aggressive primary brain tumors. Current treatments invariably fail, a consequence of the pronounced heterogen…
www.sciencedirect.com
September 4, 2025 at 8:06 AM
Thrilled to share our new study from @joycelab.bsky.social on glioblastoma, the most aggressive brain tumor. Targeting ADAR1 slows tumor growth & mobilizes the immune system — a step forward for future treatments. www.sciencedirect.com/science/arti... 🔗 1/3
Reposted by Johanna Joyce Lab
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
September 3, 2025 at 12:56 PM
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Reposted by Johanna Joyce Lab
Glioblastoma (GBM) is the most common & aggressive brain tumor - with almost no progress for patients in decades
We asked - what if we could flip the switch on an immune pathway normally used to fight viruses, and turn it against GBM? 🦠🧠
2/
We asked - what if we could flip the switch on an immune pathway normally used to fight viruses, and turn it against GBM? 🦠🧠
2/
September 3, 2025 at 12:57 PM
Glioblastoma (GBM) is the most common & aggressive brain tumor - with almost no progress for patients in decades
We asked - what if we could flip the switch on an immune pathway normally used to fight viruses, and turn it against GBM? 🦠🧠
2/
We asked - what if we could flip the switch on an immune pathway normally used to fight viruses, and turn it against GBM? 🦠🧠
2/
Reposted by Johanna Joyce Lab
By impairing ADAR1, a key RNA-sensing regulator, we uncovered a one-two punch:
- Cancer-cell intrinsic mechanisms slowed tumor proliferation in a PKR-dependent manner
- The immune microenvironment was reprogrammed into a pro-inflammatory, anti-tumoral state via type I IFN
3/
- Cancer-cell intrinsic mechanisms slowed tumor proliferation in a PKR-dependent manner
- The immune microenvironment was reprogrammed into a pro-inflammatory, anti-tumoral state via type I IFN
3/
September 3, 2025 at 12:58 PM
By impairing ADAR1, a key RNA-sensing regulator, we uncovered a one-two punch:
- Cancer-cell intrinsic mechanisms slowed tumor proliferation in a PKR-dependent manner
- The immune microenvironment was reprogrammed into a pro-inflammatory, anti-tumoral state via type I IFN
3/
- Cancer-cell intrinsic mechanisms slowed tumor proliferation in a PKR-dependent manner
- The immune microenvironment was reprogrammed into a pro-inflammatory, anti-tumoral state via type I IFN
3/
Reposted by Johanna Joyce Lab
🧐 Why does this matter?
GBM remains one of the deadliest cancers.
Targeting ADAR1 could simultaneously stop tumors from the inside - and mobilize the immune system from the outside.
These are questions that @alvarezprado.bsky.social is now pursuing in his new lab in Luxembourg
4/
GBM remains one of the deadliest cancers.
Targeting ADAR1 could simultaneously stop tumors from the inside - and mobilize the immune system from the outside.
These are questions that @alvarezprado.bsky.social is now pursuing in his new lab in Luxembourg
4/
September 3, 2025 at 12:58 PM
🧐 Why does this matter?
GBM remains one of the deadliest cancers.
Targeting ADAR1 could simultaneously stop tumors from the inside - and mobilize the immune system from the outside.
These are questions that @alvarezprado.bsky.social is now pursuing in his new lab in Luxembourg
4/
GBM remains one of the deadliest cancers.
Targeting ADAR1 could simultaneously stop tumors from the inside - and mobilize the immune system from the outside.
These are questions that @alvarezprado.bsky.social is now pursuing in his new lab in Luxembourg
4/