Glioblastoma (GBM) is the most common & aggressive brain tumor - with almost no progress for patients in decades

We asked - what if we could flip the switch on an immune pathway normally used to fight viruses, and turn it against GBM? 🦠🧠

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By impairing ADAR1, a key RNA-sensing regulator, we uncovered a one-two punch:

- Cancer-cell intrinsic mechanisms slowed tumor proliferation in a PKR-dependent manner

- The immune microenvironment was reprogrammed into a pro-inflammatory, anti-tumoral state via type I IFN

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🧐 Why does this matter?

GBM remains one of the deadliest cancers.

Targeting ADAR1 could simultaneously stop tumors from the inside - and mobilize the immune system from the outside.

These are questions that @alvarezprado.bsky.social is now pursuing in his new lab in Luxembourg

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