Subhojit Roy MD, PhD
@roylab-ucsd.bsky.social
Reposted by Subhojit Roy MD, PhD
🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons.
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
November 18, 2025 at 4:46 PM
🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons.
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social.
🔗 Check out the full #publication: bit.ly/43YpVyL
"Until recently, the reality check would come when very poor scores on the SAT and ACT. They would not have made it into a university like UCSD, which is one of the top-ranked and most selective public universities in the country"
www.theargumentmag.com/p/when-grade...
www.theargumentmag.com/p/when-grade...
When grades stop meaning anything
The UC San Diego math scandal is a warning
www.theargumentmag.com
November 19, 2025 at 3:07 AM
"Until recently, the reality check would come when very poor scores on the SAT and ACT. They would not have made it into a university like UCSD, which is one of the top-ranked and most selective public universities in the country"
www.theargumentmag.com/p/when-grade...
www.theargumentmag.com/p/when-grade...
Keying the note in Singapore on Friday Nov 28
sfn.sg/sfn-sg-annua...
sfn.sg/sfn-sg-annua...
SfN.SG Annual Symposium 2025 - Society for Neuroscience Singapore Chapter
The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will
sfn.sg
November 18, 2025 at 5:40 PM
Keying the note in Singapore on Friday Nov 28
sfn.sg/sfn-sg-annua...
sfn.sg/sfn-sg-annua...
Last ditch experiments before starting new journey!
November 5, 2025 at 1:45 AM
Last ditch experiments before starting new journey!
Transformative medical discoveries from utterly basic science is not an exception. Its the rule.
nature.com/articles/d41...
nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
nature.com
November 3, 2025 at 4:23 PM
Transformative medical discoveries from utterly basic science is not an exception. Its the rule.
nature.com/articles/d41...
nature.com/articles/d41...
"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"
November 3, 2025 at 12:10 AM
"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"
Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.
November 1, 2025 at 12:51 AM
Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.
Yup. That outta do it.
October 27, 2025 at 6:08 PM
Yup. That outta do it.
Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com
October 24, 2025 at 3:38 PM
Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com
New lab pic with people who happened to be in the area...messy, so let's assume work is getting done.
October 23, 2025 at 2:39 AM
New lab pic with people who happened to be in the area...messy, so let's assume work is getting done.
"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones"
nature.com/articles/d41...
nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
nature.com
October 22, 2025 at 3:22 PM
"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones"
nature.com/articles/d41...
nature.com/articles/d41...
lol yes...i still remember most of them
If anyone needs me I will be in the museum, lying down next to the bog bodies.
October 13, 2025 at 11:15 PM
lol yes...i still remember most of them
4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC.
www.universityofcalifornia.edu/news/uc-wins...
www.universityofcalifornia.edu/news/uc-wins...
UC wins 5 Nobel Prizes in 3 days — and sets a new world record
These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.
www.universityofcalifornia.edu
October 11, 2025 at 3:55 PM
4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC.
www.universityofcalifornia.edu/news/uc-wins...
www.universityofcalifornia.edu/news/uc-wins...
Case of the missing Lab Tupperware!
October 10, 2025 at 12:32 AM
Case of the missing Lab Tupperware!
Reposted by Subhojit Roy MD, PhD
It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 4 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re...
#forscientists
#notforprofit
#forscientists
#notforprofit
October 9, 2025 at 4:24 PM
It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 4 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re...
#forscientists
#notforprofit
#forscientists
#notforprofit
I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14: sfn.sg/sfn-sg-annua...
SfN.SG Annual Symposium 2025 - Society for Neuroscience Singapore Chapter
The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will
sfn.sg
October 7, 2025 at 1:45 AM
I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14: sfn.sg/sfn-sg-annua...
“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world"
October 3, 2025 at 11:24 PM
“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world"
"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes.
www.bbc.com/news/article...
www.bbc.com/news/article...
Huntington's disease breakthrough 'is like winning the lottery 10 times over'
Families are elated by news of the first treatment for Huntington's disease - but when and how will the NHS fund it?
www.bbc.com
September 28, 2025 at 1:11 AM
"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes.
www.bbc.com/news/article...
www.bbc.com/news/article...
Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! www.nature.com/articles/s41...
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial - Nature Medicine
Interim trial results of MYR-101, a novel recombinant vector with selective tropism for oligodendrocytes, support its tolerability and indicate improved myelination and reduced cerebrospinal fluid N-a...
www.nature.com
September 21, 2025 at 2:49 PM
Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! www.nature.com/articles/s41...
We wrote a book chapter on #CRISPR and #Alzheimers if anyone is still reading books.
link.springer.com/chapter/10.1...
link.springer.com/chapter/10.1...
CRISPR Therapies for Alzheimer’s Disease
Engineered CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) have gone from proof-of-concept to an FDA-approved drug in little more than a decade (Fig. 1). This shrunken bench-to-bes...
link.springer.com
September 4, 2025 at 7:00 PM
We wrote a book chapter on #CRISPR and #Alzheimers if anyone is still reading books.
link.springer.com/chapter/10.1...
link.springer.com/chapter/10.1...
So what are the #1 &2 journals in biochemistry ranked by impact factor? Brace yourself...1/2
www.science.org/content/blog...
www.science.org/content/blog...
September 4, 2025 at 3:22 PM
So what are the #1 &2 journals in biochemistry ranked by impact factor? Brace yourself...1/2
www.science.org/content/blog...
www.science.org/content/blog...
If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.
August 22, 2025 at 11:05 PM
If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.
Silence of the labs
www.washingtonpost.com/business/202...
www.washingtonpost.com/business/202...
Inside science labs trying to survive in the Trump era
Anastasia Khvorova’s lab at the University of Massachusetts Chan Medical School shows how quickly the administration is dismantling an 80-year partnership that made the U.S. a scientific superpower.
www.washingtonpost.com
August 12, 2025 at 1:00 AM
Silence of the labs
www.washingtonpost.com/business/202...
www.washingtonpost.com/business/202...