Roopali Khanna
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roopsiek.bsky.social
Roopali Khanna
@roopsiek.bsky.social
Integrated Ph.D student @samratmukhopadhyaylab @Iisermohali
Reposted by Roopali Khanna
The mice could be used to better understand and treat heavy menstrual bleeding, and study reproductive health conditions such as endometriosis. https://scim.ag/473mwRw
Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
scim.ag
October 22, 2025 at 10:30 PM
Reposted by Roopali Khanna
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
www.biorxiv.org
October 7, 2025 at 11:32 PM
Reposted by Roopali Khanna
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
October 6, 2025 at 1:36 PM
Reposted by Roopali Khanna
Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social.

www.science.org/doi/10.1126/...
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils
A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.
www.science.org
June 7, 2025 at 12:28 AM