Roman Doll
@romanmdoll.bsky.social
PhD Student in Medical Sciences at the University of Oxford.
If it has a genome, we can do genome editing on it, right? 🧬
If it has a genome, we can do genome editing on it, right? 🧬
Excited to share that a part of my PhD work is online now on BioRxiv!
www.biorxiv.org/content/10.6...
We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells.
Thread 👇
www.biorxiv.org/content/10.6...
We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells.
Thread 👇
December 20, 2025 at 9:37 AM
Excited to share that a part of my PhD work is online now on BioRxiv!
www.biorxiv.org/content/10.6...
We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells.
Thread 👇
www.biorxiv.org/content/10.6...
We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells.
Thread 👇
Check out the latest work from the @davieslab.bsky.social led by Hangpeng!
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 6, 2025 at 10:11 AM
Check out the latest work from the @davieslab.bsky.social led by Hangpeng!
Reposted by Roman Doll
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 15, 2025 at 8:32 PM
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Roman Doll
Our new preprint is out - please share!
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
December 2, 2024 at 3:16 PM
Our new preprint is out - please share!
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
Feels like the migration of science twitter is actually working this time? Exciting!
November 20, 2024 at 2:24 PM
Feels like the migration of science twitter is actually working this time? Exciting!
Some quite interesting observations on length bias of different PCR polymerases, from www.nature.com/articles/s41...
Maybe I need to reconsider my unconditional love for Q5...
Maybe I need to reconsider my unconditional love for Q5...
November 11, 2024 at 6:25 PM
Some quite interesting observations on length bias of different PCR polymerases, from www.nature.com/articles/s41...
Maybe I need to reconsider my unconditional love for Q5...
Maybe I need to reconsider my unconditional love for Q5...