Roger Borràs
@rogerborras.bsky.social
Mathematician, biostatistician, gamer, skier, violinist & R lover. Evidence-Based Medicine. Hospital Clínic de BCN. @idibaps @CIBER_ESP. Professor @UABBarcelona
Reposted by Roger Borràs
You categorised patients as responders or non responders by dichotomising a change from baseline?
You triple criminal!
You triple criminal!
November 8, 2025 at 7:33 PM
You categorised patients as responders or non responders by dichotomising a change from baseline?
You triple criminal!
You triple criminal!
Reposted by Roger Borràs
I just posted a critique of this paper at discourse.datamethods.org/t/critique-o... where I hope others will add their thoughts #StatsSky #EpiSky #Statistics #rct
November 9, 2025 at 3:56 PM
I just posted a critique of this paper at discourse.datamethods.org/t/critique-o... where I hope others will add their thoughts #StatsSky #EpiSky #Statistics #rct
Reposted by Roger Borràs
The advances we've made in statistics, experimental study design, and causal inference over the past century are remarkably useful for understanding our world. But there is never been a push to make people use them like we are seeing with generative AI. Perhaps take a moment to consider why.
November 7, 2025 at 9:07 AM
The advances we've made in statistics, experimental study design, and causal inference over the past century are remarkably useful for understanding our world. But there is never been a push to make people use them like we are seeing with generative AI. Perhaps take a moment to consider why.
Reposted by Roger Borràs
Stop interpreting clinical trials as if they were surveys.
www.linkedin.com/pulse/illegi...
www.linkedin.com/pulse/illegi...
Illegible Eligible
Several times recently, in published papers and in papers I have been asked to review, I have come across the quite incorrect claim that the eligibility criteria of a clinical trial define the target ...
www.linkedin.com
November 2, 2025 at 10:50 AM
Stop interpreting clinical trials as if they were surveys.
www.linkedin.com/pulse/illegi...
www.linkedin.com/pulse/illegi...
Reposted by Roger Borràs
Miguel Hernán is presenting at EFSPI and giving a frankly embarrassing rant about (addendum-style) estimands. While lots of people are constructively using it to complement causal inference, he is sticking to basic & straw-man gripes that are easily addressed by thinking or listening to others.
September 10, 2025 at 1:29 PM
Miguel Hernán is presenting at EFSPI and giving a frankly embarrassing rant about (addendum-style) estimands. While lots of people are constructively using it to complement causal inference, he is sticking to basic & straw-man gripes that are easily addressed by thinking or listening to others.
Reposted by Roger Borràs
Terrific @scientificdiscovery.dev post on randomized controlled trials in @ourworldindata.org.
Including this important chart on the impact of pre-registration.
Magically, when people had to pre-register outcomes, many of the benefits disappeared.
ourworldindata.org/randomized-c...
Including this important chart on the impact of pre-registration.
Magically, when people had to pre-register outcomes, many of the benefits disappeared.
ourworldindata.org/randomized-c...
September 24, 2025 at 5:52 PM
Terrific @scientificdiscovery.dev post on randomized controlled trials in @ourworldindata.org.
Including this important chart on the impact of pre-registration.
Magically, when people had to pre-register outcomes, many of the benefits disappeared.
ourworldindata.org/randomized-c...
Including this important chart on the impact of pre-registration.
Magically, when people had to pre-register outcomes, many of the benefits disappeared.
ourworldindata.org/randomized-c...
Reposted by Roger Borràs
Thanks Paul. It’s nice to have a paper that’s both elegant (if I may say so) and practically useful. The conclusion is that using a particular covariate balancing PS estimator — inverse probability tilting — renders IPW, AIPW, and IPWRA all numerically identical with a linear conditional mean.
This new CESifo working paper on covariate balancing looks very interesting. @jmwooldridge.bsky.social
Link: www.ifo.de/DocDL/cesifo...
Link: www.ifo.de/DocDL/cesifo...
September 23, 2025 at 6:45 PM
Thanks Paul. It’s nice to have a paper that’s both elegant (if I may say so) and practically useful. The conclusion is that using a particular covariate balancing PS estimator — inverse probability tilting — renders IPW, AIPW, and IPWRA all numerically identical with a linear conditional mean.
Reposted by Roger Borràs
Perfectly stated Darren. Don’t anyone think this is an exaggeration. I’ve seen this in supposedly reputable cardiology journals, sometimes even with omission of “by drawing a DAG”.
We didn't randomize, and there was no allocation concealment or blinding, and we can't really be sure what intervention they got or how the outcomes were measured, but we emulated a trial by drawing a DAG.
September 1, 2025 at 12:57 PM
Perfectly stated Darren. Don’t anyone think this is an exaggeration. I’ve seen this in supposedly reputable cardiology journals, sometimes even with omission of “by drawing a DAG”.
Reposted by Roger Borràs
We didn't randomize, and there was no allocation concealment or blinding, and we can't really be sure what intervention they got or how the outcomes were measured, but we emulated a trial by drawing a DAG.
August 31, 2025 at 3:21 PM
We didn't randomize, and there was no allocation concealment or blinding, and we can't really be sure what intervention they got or how the outcomes were measured, but we emulated a trial by drawing a DAG.
Reposted by Roger Borràs
Pleased to report on two papers on #ANVOVA with @poschm.bsky.social and Franz König
The first lnkd.in/eKmjiQdk
looks at median stratification for a single covariate.
The second lnkd.in/e3DH96G8
considers adjustment for many covariates.
Variance inflation factors are key.
The first lnkd.in/eKmjiQdk
looks at median stratification for a single covariate.
The second lnkd.in/e3DH96G8
considers adjustment for many covariates.
Variance inflation factors are key.
August 12, 2025 at 1:02 PM
Pleased to report on two papers on #ANVOVA with @poschm.bsky.social and Franz König
The first lnkd.in/eKmjiQdk
looks at median stratification for a single covariate.
The second lnkd.in/e3DH96G8
considers adjustment for many covariates.
Variance inflation factors are key.
The first lnkd.in/eKmjiQdk
looks at median stratification for a single covariate.
The second lnkd.in/e3DH96G8
considers adjustment for many covariates.
Variance inflation factors are key.
Reposted by Roger Borràs
A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine
August 10, 2025 at 12:26 AM
A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine
Reposted by Roger Borràs
It seems like a lot of systematic-reviews/meta-analyses are analogous to money laundering. You run a load of studies that nobody actually reads, many of them "dirty", through some process. On the other end you get "clean" results that the ignorant or deceitful can easily communicate as "evidence".
July 23, 2025 at 10:15 AM
It seems like a lot of systematic-reviews/meta-analyses are analogous to money laundering. You run a load of studies that nobody actually reads, many of them "dirty", through some process. On the other end you get "clean" results that the ignorant or deceitful can easily communicate as "evidence".
Reposted by Roger Borràs
Reposted by Roger Borràs
Even @robcaliff.bsky.social says "real world" data is only at the "promise" stage. The only thing it seems to be "missing" is accuracy, completeness, and the ability to account for bias. Their words not mine! 😜 www.nejm.org/doi/full/10....
ht @emilymoin.com
ht @emilymoin.com
July 24, 2025 at 5:15 AM
Even @robcaliff.bsky.social says "real world" data is only at the "promise" stage. The only thing it seems to be "missing" is accuracy, completeness, and the ability to account for bias. Their words not mine! 😜 www.nejm.org/doi/full/10....
ht @emilymoin.com
ht @emilymoin.com
Reposted by Roger Borràs
@xkcd.com again provides for your meta-science slides (link xkcd.com/3117). I do wish we'd stop talking about a "crisis", bc it's been here for generations. Ppl used to pipette by mouth ffs. Enrico Fermi won a Nobel prize for a false result. But that doesn't mean we can't do better going forward.
July 20, 2025 at 5:27 AM
@xkcd.com again provides for your meta-science slides (link xkcd.com/3117). I do wish we'd stop talking about a "crisis", bc it's been here for generations. Ppl used to pipette by mouth ffs. Enrico Fermi won a Nobel prize for a false result. But that doesn't mean we can't do better going forward.
Reposted by Roger Borràs
Time for your yearly reminder that “We need less research, better research, and research done for the right reasons”. #OTD 1948 Douglas Altman b (d 3 June 2018) “One of the most influential medical statisticians of the past 50 years” he led reforms in medical research reliability & reporting. 1/3
July 12, 2025 at 12:06 PM
Time for your yearly reminder that “We need less research, better research, and research done for the right reasons”. #OTD 1948 Douglas Altman b (d 3 June 2018) “One of the most influential medical statisticians of the past 50 years” he led reforms in medical research reliability & reporting. 1/3
Reposted by Roger Borràs
There is no scientific concept of "real world" data or evidence - there is nothing about this terminology that can't be more accurately and honestly conveyed using other accepted methodological terms.
We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!
July 7, 2025 at 11:42 AM
There is no scientific concept of "real world" data or evidence - there is nothing about this terminology that can't be more accurately and honestly conveyed using other accepted methodological terms.
Reposted by Roger Borràs
Reposted by Roger Borràs
"Do not sneer at those who think that clinical trials enroll representative samples, for internet polls show they are in the majority." Sayings of Confuseus
June 16, 2025 at 10:25 AM
"Do not sneer at those who think that clinical trials enroll representative samples, for internet polls show they are in the majority." Sayings of Confuseus
Reposted by Roger Borràs
La Vanguardia entrevista la investigadora de l'#IDIBAPS Sònia Guedan, finalista dels premis @lavanguardia.com de la ciencia.
La pots votar en aquest enllaç 👉https://f.mtr.cool/eshdnngnre
La pots votar en aquest enllaç 👉https://f.mtr.cool/eshdnngnre
June 10, 2025 at 12:04 PM
La Vanguardia entrevista la investigadora de l'#IDIBAPS Sònia Guedan, finalista dels premis @lavanguardia.com de la ciencia.
La pots votar en aquest enllaç 👉https://f.mtr.cool/eshdnngnre
La pots votar en aquest enllaç 👉https://f.mtr.cool/eshdnngnre
Reposted by Roger Borràs
Starting to look like I might not be able to work at Harvard anymore due to recent funding cuts. If you know of any open statistical consulting positions that support remote work or are NYC-based, please reach out! 😅
June 4, 2025 at 7:02 PM
Starting to look like I might not be able to work at Harvard anymore due to recent funding cuts. If you know of any open statistical consulting positions that support remote work or are NYC-based, please reach out! 😅
Reposted by Roger Borràs
Reposted by Roger Borràs
Amazing job, summarizing 260 RCTs of vaccines with nearly 2.5 million patients randomized! We will turn this into a peer reviewed manuscript, but the table summarizing the trials can be seen on the web:
www.bradspellberg.com/vaccine-rcts
www.bradspellberg.com/vaccine-rcts
May 29, 2025 at 5:39 PM
Amazing job, summarizing 260 RCTs of vaccines with nearly 2.5 million patients randomized! We will turn this into a peer reviewed manuscript, but the table summarizing the trials can be seen on the web:
www.bradspellberg.com/vaccine-rcts
www.bradspellberg.com/vaccine-rcts