Brad Spellberg
@bradspellberg.bsky.social
Reposted by Brad Spellberg
📢📢📢 We are delighted to announce that we are assembling team for our next project, Pharyngitis WikiGuideline
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
November 3, 2025 at 12:07 AM
📢📢📢 We are delighted to announce that we are assembling team for our next project, Pharyngitis WikiGuideline
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Thanks to @abimfoundation.bsky.social ation for posting the video of my recent lecture on the LA General Policy to Override Policies. For those of you who know my lectures, this one is among the most entertaining. And it's only 10 min. Check it out & implement the policy!
youtu.be/RuKAKH8A604?...
youtu.be/RuKAKH8A604?...
Administrator/Clinician Collaboration: Policies to Put Patients First
YouTube video by ABIM Foundation
youtu.be
September 5, 2025 at 2:05 AM
Thanks to @abimfoundation.bsky.social ation for posting the video of my recent lecture on the LA General Policy to Override Policies. For those of you who know my lectures, this one is among the most entertaining. And it's only 10 min. Check it out & implement the policy!
youtu.be/RuKAKH8A604?...
youtu.be/RuKAKH8A604?...
Reposted by Brad Spellberg
Another plug for #wikiguidelines @bradspellberg.bsky.social
When guidelines don’t keep up with medicine
When guidelines don’t keep up with medicine
UNMC ID faculty Dr. Jenn Davis and 🌟 resident Dr. Gigi Green joined up to publish an interesting case in @cidjournal.bsky.social as part of the Clinical Delimmas in ID series:
"A Blurry Line: Navigating Treatment Decisions When the Guidelines Don't Fit"
#IDSky
academic.oup.com/cid/advance-...
"A Blurry Line: Navigating Treatment Decisions When the Guidelines Don't Fit"
#IDSky
academic.oup.com/cid/advance-...
A Blurry Line: Navigating Treatment Decisions When the Guidelines Don’t Fit
A 45-year-old female was referred to the infectious diseases (ID) clinic for interpretation of discordant human immunodeficiency virus (HIV) test results.
academic.oup.com
August 22, 2025 at 3:38 PM
Another plug for #wikiguidelines @bradspellberg.bsky.social
When guidelines don’t keep up with medicine
When guidelines don’t keep up with medicine
Reposted by Brad Spellberg
Reposted by Brad Spellberg
I love Dalba
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
a white monkey with a blue face is sitting on a blue blanket .
ALT: a white monkey with a blue face is sitting on a blue blanket .
media.tenor.com
August 13, 2025 at 11:41 PM
I love Dalba
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
Reposted by Brad Spellberg
As @bradspellberg.bsky.social would say CRP is missing a letter as a test "A" (CRAP) - www.sciencedirect.com/science/arti...
Revisiting diagnostics: erythrocyte sedimentation rate and C-reactive protein: it is time to stop the zombie tests
www.sciencedirect.com
August 12, 2025 at 5:07 AM
As @bradspellberg.bsky.social would say CRP is missing a letter as a test "A" (CRAP) - www.sciencedirect.com/science/arti...
Reposted by Brad Spellberg
International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding.
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis
This systematic review and meta-analysis evaluates the evidence supporting the current guidelines antibiotic prophylaxis use in patients with cirrhosis and upper gastrointestinal bleeding.
jamanetwork.com
August 11, 2025 at 4:20 PM
International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding.
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
Reposted by Brad Spellberg
#IDsky The Infectious Disease Brad Boy himself, @bradspellberg.bsky.social , has an updated Oral vs IV table, now including the Plague (Y really) and Lyme!
Link here:
www.bradspellberg.com/oral-antibio...
Link here:
www.bradspellberg.com/oral-antibio...
Oral Antibiotic RCTs | mysite
www.bradspellberg.com
August 9, 2025 at 6:48 PM
#IDsky The Infectious Disease Brad Boy himself, @bradspellberg.bsky.social , has an updated Oral vs IV table, now including the Plague (Y really) and Lyme!
Link here:
www.bradspellberg.com/oral-antibio...
Link here:
www.bradspellberg.com/oral-antibio...
Reposted by Brad Spellberg
WikiGuidelines lapel pins are available for purchase on
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
August 3, 2025 at 5:02 PM
WikiGuidelines lapel pins are available for purchase on
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
Reposted by Brad Spellberg
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
Bactericidal vs Bacteriostatic Antibiotics. This controversial topic has important conceptual ramifications to treat severe infections. youtu.be/3z4BItBrzbk
Bactericidal vs Bacteriostatic Antibiotics - Editors in Conversation Podcast, Live from ASM Microbe
YouTube video by American Society for Microbiology
youtu.be
July 10, 2025 at 4:26 PM
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
Really compelling story by @corinnepurtill: "Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center". This short video tells the powerful story of the unidentified admissions to one of the busiest trauma centers in the US.
www.latimes.com/00000197-c35...
www.latimes.com/00000197-c35...
LA Times Today: Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center
Watch L.A.
www.latimes.com
July 3, 2025 at 12:19 AM
Really compelling story by @corinnepurtill: "Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center". This short video tells the powerful story of the unidentified admissions to one of the busiest trauma centers in the US.
www.latimes.com/00000197-c35...
www.latimes.com/00000197-c35...
Reposted by Brad Spellberg
Great article on dogma in ID (with parallels to critical care)
We have HUGE problems re: guidelines making recommendations & *redefining* entire diseases based on minimal data.
Gov't metrics exacerbate this further.
@bradspellberg.bsky.social @absteward.bsky.social @drtoddlee.bsky.social #EMIMCC
We have HUGE problems re: guidelines making recommendations & *redefining* entire diseases based on minimal data.
Gov't metrics exacerbate this further.
@bradspellberg.bsky.social @absteward.bsky.social @drtoddlee.bsky.social #EMIMCC
June 26, 2025 at 11:47 AM
Great article on dogma in ID (with parallels to critical care)
We have HUGE problems re: guidelines making recommendations & *redefining* entire diseases based on minimal data.
Gov't metrics exacerbate this further.
@bradspellberg.bsky.social @absteward.bsky.social @drtoddlee.bsky.social #EMIMCC
We have HUGE problems re: guidelines making recommendations & *redefining* entire diseases based on minimal data.
Gov't metrics exacerbate this further.
@bradspellberg.bsky.social @absteward.bsky.social @drtoddlee.bsky.social #EMIMCC
Reposted by Brad Spellberg
Oh snap! I hope this conversation happened near a hospital that has a burn unit @bradspellberg.bsky.social
June 26, 2025 at 12:08 AM
Oh snap! I hope this conversation happened near a hospital that has a burn unit @bradspellberg.bsky.social
Reposted by Brad Spellberg
How much evidence is needed to revise established clinical practices? and, can data alone truly catalyze such shifts?
Our 🆕🔥 Article at @cidjournal.bsky.social with 🌟s @bradspellberg.bsky.social
Practicing With Intent: How to Teach an Old Dogma New Tricks #IDSky
academic.oup.com/cid/article/...
Our 🆕🔥 Article at @cidjournal.bsky.social with 🌟s @bradspellberg.bsky.social
Practicing With Intent: How to Teach an Old Dogma New Tricks #IDSky
academic.oup.com/cid/article/...
June 24, 2025 at 1:12 PM
How much evidence is needed to revise established clinical practices? and, can data alone truly catalyze such shifts?
Our 🆕🔥 Article at @cidjournal.bsky.social with 🌟s @bradspellberg.bsky.social
Practicing With Intent: How to Teach an Old Dogma New Tricks #IDSky
academic.oup.com/cid/article/...
Our 🆕🔥 Article at @cidjournal.bsky.social with 🌟s @bradspellberg.bsky.social
Practicing With Intent: How to Teach an Old Dogma New Tricks #IDSky
academic.oup.com/cid/article/...
Thank you to @jamanetworkopen.com for publishing economic analysis of our Safer@Home virtual acute care program! Modeling shows simple reimbursement would enable a win-win-win: patients get better patient-centered care, hospitals save money/free beds, and payors save!
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Health Economic Analysis of an All-Virtual, At-Home Acute Care Model
This economic evaluation estimates hospital and payer costs associated with an all-virtual, at-home acute care program.
jamanetwork.com
June 23, 2025 at 7:45 PM
Thank you to @jamanetworkopen.com for publishing economic analysis of our Safer@Home virtual acute care program! Modeling shows simple reimbursement would enable a win-win-win: patients get better patient-centered care, hospitals save money/free beds, and payors save!
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Brad Spellberg
The work has been deeply collaborative. The idea to crowdsource controlled vaccine trials came from
@bradspellberg.bsky.social, and we've had a phenomenal team - @abhaydhand.bsky.social, @alejodiaz81.bsky.social, Dr. Ali Meza Vazquez, Neal Fox, and help from many contributors from around the world.
@bradspellberg.bsky.social, and we've had a phenomenal team - @abhaydhand.bsky.social, @alejodiaz81.bsky.social, Dr. Ali Meza Vazquez, Neal Fox, and help from many contributors from around the world.
June 6, 2025 at 9:48 PM
The work has been deeply collaborative. The idea to crowdsource controlled vaccine trials came from
@bradspellberg.bsky.social, and we've had a phenomenal team - @abhaydhand.bsky.social, @alejodiaz81.bsky.social, Dr. Ali Meza Vazquez, Neal Fox, and help from many contributors from around the world.
@bradspellberg.bsky.social, and we've had a phenomenal team - @abhaydhand.bsky.social, @alejodiaz81.bsky.social, Dr. Ali Meza Vazquez, Neal Fox, and help from many contributors from around the world.
Reposted by Brad Spellberg
Reposted by Brad Spellberg
Your Role: Review existing guidelines across all specialties to evaluate whether or not recommendations are based on high-quality, adequately powered, peer-reviewed, and publicly accessible prospective studies, including at least one randomized controlled trial
June 5, 2025 at 3:23 PM
Your Role: Review existing guidelines across all specialties to evaluate whether or not recommendations are based on high-quality, adequately powered, peer-reviewed, and publicly accessible prospective studies, including at least one randomized controlled trial
Reposted by Brad Spellberg
📢📢📢Join our team appraising the level of evidence used to make consensus guideline recommendations across all specialties
Deadline to sign up: 6/20/25
New to WikiGuidelines?
Use the link below to complete WikiGuidelines New Participant application. forms.office.com/r/Tyb8R0iM8X
Deadline to sign up: 6/20/25
New to WikiGuidelines?
Use the link below to complete WikiGuidelines New Participant application. forms.office.com/r/Tyb8R0iM8X
June 5, 2025 at 3:23 PM
📢📢📢Join our team appraising the level of evidence used to make consensus guideline recommendations across all specialties
Deadline to sign up: 6/20/25
New to WikiGuidelines?
Use the link below to complete WikiGuidelines New Participant application. forms.office.com/r/Tyb8R0iM8X
Deadline to sign up: 6/20/25
New to WikiGuidelines?
Use the link below to complete WikiGuidelines New Participant application. forms.office.com/r/Tyb8R0iM8X
Amazing job, summarizing 260 RCTs of vaccines with nearly 2.5 million patients randomized! We will turn this into a peer reviewed manuscript, but the table summarizing the trials can be seen on the web:
www.bradspellberg.com/vaccine-rcts
www.bradspellberg.com/vaccine-rcts
May 29, 2025 at 5:39 PM
Amazing job, summarizing 260 RCTs of vaccines with nearly 2.5 million patients randomized! We will turn this into a peer reviewed manuscript, but the table summarizing the trials can be seen on the web:
www.bradspellberg.com/vaccine-rcts
www.bradspellberg.com/vaccine-rcts
Reposted by Brad Spellberg
Just wrapped data extraction for our global vaccine RCT review:
260 trials (1951 to 2025)
2,468,751 trial participants
Possibly the most comprehensive dataset of its kind.
Huge thanks to the team that powered through to this milestone.
@bradspellberg.bsky.social
docs.google.com/spreadsheets/d…
260 trials (1951 to 2025)
2,468,751 trial participants
Possibly the most comprehensive dataset of its kind.
Huge thanks to the team that powered through to this milestone.
@bradspellberg.bsky.social
docs.google.com/spreadsheets/d…
https://docs.google.com/spreadsheets/d…
May 29, 2025 at 5:34 PM
Just wrapped data extraction for our global vaccine RCT review:
260 trials (1951 to 2025)
2,468,751 trial participants
Possibly the most comprehensive dataset of its kind.
Huge thanks to the team that powered through to this milestone.
@bradspellberg.bsky.social
docs.google.com/spreadsheets/d…
260 trials (1951 to 2025)
2,468,751 trial participants
Possibly the most comprehensive dataset of its kind.
Huge thanks to the team that powered through to this milestone.
@bradspellberg.bsky.social
docs.google.com/spreadsheets/d…
LA General is seeking a Director of Inflammatory Bowel Disease and Director of GI Ambulatory Care in the Division of Gastroenterology and Hepatology. See job description attached!
May 27, 2025 at 8:18 PM
LA General is seeking a Director of Inflammatory Bowel Disease and Director of GI Ambulatory Care in the Division of Gastroenterology and Hepatology. See job description attached!
Thanks to @absteward.bsky.social for finding the most recent Shorter is Better: TB Is Complex Study. Shows 8 week regimens are inferior to 24 week for cure. Sets a lower boundary for TB. Slides and website updated.
www.bradspellberg.com/shorter-is-b...
www.bradspellberg.com/shorter-is-b...
May 25, 2025 at 6:05 PM
Thanks to @absteward.bsky.social for finding the most recent Shorter is Better: TB Is Complex Study. Shows 8 week regimens are inferior to 24 week for cure. Sets a lower boundary for TB. Slides and website updated.
www.bradspellberg.com/shorter-is-b...
www.bradspellberg.com/shorter-is-b...
Reposted by Brad Spellberg
Our crowd-sourced spreadsheet of controlled vaccine RCTs just hit 189 trials - spanning Adenovirus to Zika & 2.1 million participants. Every row links to the primary paper.
More to come...
docs.google.com/spreadsheets/d…
@bradspellberg.bsky.social
@apnews.com @statnews.com @nytimes.com
More to come...
docs.google.com/spreadsheets/d…
@bradspellberg.bsky.social
@apnews.com @statnews.com @nytimes.com
https://docs.google.com/spreadsheets/d…
May 25, 2025 at 12:57 PM
Our crowd-sourced spreadsheet of controlled vaccine RCTs just hit 189 trials - spanning Adenovirus to Zika & 2.1 million participants. Every row links to the primary paper.
More to come...
docs.google.com/spreadsheets/d…
@bradspellberg.bsky.social
@apnews.com @statnews.com @nytimes.com
More to come...
docs.google.com/spreadsheets/d…
@bradspellberg.bsky.social
@apnews.com @statnews.com @nytimes.com
Reposted by Brad Spellberg
The results of this study call into question the accuracy of susceptibility testing for organisms containing MBLs when conducted in nutrient-rich media and reiterate the need for clinical validation of in vitro susceptibility testing results #idsky
🆕🌟Super interesting!
The study challenges IDSA guidance which recommend against the use of CAZ for treatment of S.maltophilia
Ceftazidime retains in vivo efficacy against strains of Stenotrophomonas maltophilia for which traditional testing predicts resistance #idsky
journals.asm.org/doi/10.1128/...
The study challenges IDSA guidance which recommend against the use of CAZ for treatment of S.maltophilia
Ceftazidime retains in vivo efficacy against strains of Stenotrophomonas maltophilia for which traditional testing predicts resistance #idsky
journals.asm.org/doi/10.1128/...
Ceftazidime retains in vivo efficacy against strains of Stenotrophomonas maltophilia for which traditional testing predicts resistance | mSphere
Breakpoint interpretation criteria for ceftazidime against S. maltophilia were recently removed by CLSI and the FDA. It was noted that clinical data were insufficient
to validate the current breakpoin...
journals.asm.org
May 23, 2025 at 11:59 AM
The results of this study call into question the accuracy of susceptibility testing for organisms containing MBLs when conducted in nutrient-rich media and reiterate the need for clinical validation of in vitro susceptibility testing results #idsky