Rasmus Hartmann-Petersen
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rhp-lab.bsky.social
Rasmus Hartmann-Petersen
@rhp-lab.bsky.social
380 followers 380 following 3 posts
Professor at the Linderstrøm-Lang Centre for Protein Science, University of Copenhagen.
Interests: Protein Quality Control, Genetics, Molecular Chaperones, Degrons.
Posts Replies Media Videos
Reposted by Rasmus Hartmann-Petersen
lindorfflarsen.bsky.social
The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...
Fig. 1 – UBQLN2 is a conserved lysine-depleted protein. (A) Sequence comparison of UBQLN2 orthologs in the indicated species. Intrinsically disordered regions in human UBQLN2 based on MobiDB are shown as a blue bar. The domain organization based on the SMART database is marked. Lysine residues are marked as black squares. (B) ESM-2 predictions of all possible single amino acid substitutions of human UBQLN2 presented as a heat map. The wild-type residues are marked in blue. ESM-2 scores close to zero (light yellow colors) indicate that the amino acid substitution is compatible with the ESM-2 language model, whereas negative scores (dark orange colors) indicate that the variant is incompatible with the ESM-2 model. The domain organization (based on SMART) is aligned above the map. Note that substitutions to lysine or cysteine in general appear detrimental, in particular downstream of the UBL domain. (C) The AlphaFold2 predicted structured of human UBQLN2 (AF-Q9UHD9-F1) (left panel). The UBL domain is colored blue, and the UBA domain is colored orange and the STI1 regions green. Zoom in on the UBL domain (right panel) with the lysine residues highlighted as stick representations and colored based on the relative accessible surface area (rASA, dark red exposed; grey, buried).
October 7, 2025 at 9:20 PM
Reposted by Rasmus Hartmann-Petersen
lindorfflarsen.bsky.social
Martin Grønbæk-Thygesen in @rhp-lab.bsky.social measured abundance and toxicity (both independently of function) of missense variants in aspartoacylase, and found that a subset of the low-abundance variants were toxic, induced a stress response which correlated with toxicity

doi.org/10.1038/s414...
September 19, 2025 at 8:57 PM
Reposted by Rasmus Hartmann-Petersen
lindorfflarsen.bsky.social
I’m biased 🇩🇰, but this is quite nice to read:

I thought science hinged on prestige. Moving abroad made me reassess my priorities

www.science.org/content/arti...
I thought science hinged on prestige. Moving abroad made me reassess my priorities
In Denmark, this Ph.D. student fell in love with an egalitarian society that values work-life balance
www.science.org
September 12, 2025 at 7:50 AM
Reposted by Rasmus Hartmann-Petersen
pmc-modularity.bsky.social
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
August 15, 2025 at 3:36 PM
Reposted by Rasmus Hartmann-Petersen
eliweinstein.bsky.social
I'm looking for my first PhD student! We will push the frontiers of probabilistic machine learning for the molecular sciences, and study how to design new algorithms that exploit the unique properties of molecular systems to learn about the world.

efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
PhD scholarship in Machine Learning for Molecules - DTU Chemistry
Advance large scale data generation for chemical and biological AI in a 3 year PhD. Work on the frontier of active learning, and develop novel probabilistic machine learning techniques for experiment ...
efzu.fa.em2.oraclecloud.com
July 24, 2025 at 8:25 PM
Reposted by Rasmus Hartmann-Petersen
carolinefwright.bsky.social
Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social
www.ft.com/content/25dd...
Curiosity underlies a breakthrough in rare disease
We must recognise and protect the pipelines that lead from research to real-world benefit
www.ft.com
May 29, 2025 at 8:44 AM
Reposted by Rasmus Hartmann-Petersen
isabellease.bsky.social
@lindorfflarsen.bsky.social at #VariantEffect25
May 23, 2025 at 8:46 AM
rhp-lab.bsky.social
With the @lindorfflarsen.bsky.social group we present our map of degrons in all human transcription factors, incl. examples of constitutive degrons in exposed regions & buried degrons that are exposed upon mutation. In addition, we show that most TADs overlap with degrons. Work led by Fia Larsen.
Comprehensive degron mapping in human transcription factors
Gene expression is regulated by the targeted degradation of transcription factors through the ubiquitin-proteasome system. Transcription factors destined for degradation are recognized by E3 ubiquitin...
www.biorxiv.org
May 18, 2025 at 4:59 AM
rhp-lab.bsky.social
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
www.biorxiv.org
May 15, 2025 at 11:56 AM
Reposted by Rasmus Hartmann-Petersen
hemmo-lab.bsky.social
We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin
April 23, 2025 at 9:56 PM
Reposted by Rasmus Hartmann-Petersen
cp-trendsbiochem.bsky.social
... wait! There's more great Review content!
☘️ mechanisms of #SAM homeostasis (Ben Tu et al)
☘️ glucose sensing by #glucokinase and how disease variants impact its function @sarahgersing.bsky.social @lindorfflarsen.bsky.social @rhp-lab.bsky.social
March 6, 2025 at 4:43 PM
Reposted by Rasmus Hartmann-Petersen
cp-trendsbiochem.bsky.social
Now online - the Review "#Glucokinase: from allosteric glucose sensing to disease variants" from @sarahgersing.bsky.social, Torben Hansen, @lindorfflarsen.bsky.social, and @rhp-lab.bsky.social.

#GlucoseHomeostasis #GlucoseSensor #GCKMODY #CooperativeKinetics

authors.elsevier.com/a/1kN5M3S6Gf...
January 3, 2025 at 4:40 PM
Reposted by Rasmus Hartmann-Petersen
sarahgersing.bsky.social
Happy to share our review, 'Glucokinase: from allosteric glucose sensing to disease variants', published in @cp-trendsbiochem.bsky.social, which explores the fascinating enzyme glucokinase. authors.elsevier.com/a/1kN5M3S6Gf...
authors.elsevier.com
January 2, 2025 at 7:35 PM
rhp-lab.bsky.social
In our new paper we characterize the effects of indel variants on protein folding and stability using a new yeast-based protein folding sensor. The work was led by Sven Larsen-Ledet and supported by the @novo-nordisk.bsky.social.
Link to paper: www.cell.com/structure/fu...
Systematic characterization of indel variants using a yeast-based protein folding sensor
Larsen-Ledet et al. developed a yeast-based protein folding sensor to determine the effects of indel variants in DHFR. Using a saturated indel library, it was found that most indels are not tolerated. Several are temperature sensitive and folding is rescued by methotrexate. Rosetta and AlphaFold2 predictions correlate with the observed effects.
www.cell.com
December 20, 2024 at 7:26 AM