@reneegoh.bsky.social
Reposted
January 23, 2025 at 2:31 PM
Reposted
Can we treat patients with low-risk BSI discharged from the ED with a fully-oral course of antibiotics?
[Spoiler: Yes!]
🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...
Food for thought for #AMSsky #IDSky
[Spoiler: Yes!]
🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...
Food for thought for #AMSsky #IDSky
Safety of early oral ambulatory treatment of adult patients with bloodstream infections discharged from the emergency department | Antimicrobial Agents and Chemotherapy
Randomized trials have unanimously shown the benefits of oral antibiotic treatments for stable patients with bacteremia (1). However, transition to oral therapy has been usually performed after several days of intravenous treatment—frequently up to 7 days (2)—highlighting the need for evidence of the safety of earlier oral treatments (3).
journals.asm.org
November 12, 2024 at 7:30 PM
Can we treat patients with low-risk BSI discharged from the ED with a fully-oral course of antibiotics?
[Spoiler: Yes!]
🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...
Food for thought for #AMSsky #IDSky
[Spoiler: Yes!]
🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...
Food for thought for #AMSsky #IDSky
Reposted
My Top 5 Antibiotic Allergy Papers - #3
Cheating.... best cross-reactivity
▶️Strom. NEJM 2003
❌ cross-reactivity b/w antibiotic- & non-anti "sulfurs"
www.nejm.org/doi/10.1056/...
▶️Picard. JACI In Prac 2019
Meta-analysis, 2% cross-reactivity. All great Romano📜
www.jaci-inpractice.org/article/S221...
Cheating.... best cross-reactivity
▶️Strom. NEJM 2003
❌ cross-reactivity b/w antibiotic- & non-anti "sulfurs"
www.nejm.org/doi/10.1056/...
▶️Picard. JACI In Prac 2019
Meta-analysis, 2% cross-reactivity. All great Romano📜
www.jaci-inpractice.org/article/S221...
Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamide Nonantibiotics | NEJM
The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic
reactions to sulfonamide antibiotics. We conducted a retrospective cohort study using
the General Practice Resear...
www.nejm.org
November 12, 2024 at 8:00 AM
My Top 5 Antibiotic Allergy Papers - #3
Cheating.... best cross-reactivity
▶️Strom. NEJM 2003
❌ cross-reactivity b/w antibiotic- & non-anti "sulfurs"
www.nejm.org/doi/10.1056/...
▶️Picard. JACI In Prac 2019
Meta-analysis, 2% cross-reactivity. All great Romano📜
www.jaci-inpractice.org/article/S221...
Cheating.... best cross-reactivity
▶️Strom. NEJM 2003
❌ cross-reactivity b/w antibiotic- & non-anti "sulfurs"
www.nejm.org/doi/10.1056/...
▶️Picard. JACI In Prac 2019
Meta-analysis, 2% cross-reactivity. All great Romano📜
www.jaci-inpractice.org/article/S221...
Reposted
1/11
🤔Why does chronic hepatitis C infection "require" the intermediary of cirrhosis in order to cause hepatocellular carcinoma (HCC)?
Chronic hepatitis B can "skip" this step, going directly from chronic infection to HCC.
Why the difference?
🤔Why does chronic hepatitis C infection "require" the intermediary of cirrhosis in order to cause hepatocellular carcinoma (HCC)?
Chronic hepatitis B can "skip" this step, going directly from chronic infection to HCC.
Why the difference?
November 11, 2024 at 9:02 PM
1/11
🤔Why does chronic hepatitis C infection "require" the intermediary of cirrhosis in order to cause hepatocellular carcinoma (HCC)?
Chronic hepatitis B can "skip" this step, going directly from chronic infection to HCC.
Why the difference?
🤔Why does chronic hepatitis C infection "require" the intermediary of cirrhosis in order to cause hepatocellular carcinoma (HCC)?
Chronic hepatitis B can "skip" this step, going directly from chronic infection to HCC.
Why the difference?
Reposted
Slidedeck from an internal presentation on diabetic kidney disease 👇
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on #Kidney Disease in people with #diabetes #flozin #sglt2i #MRA #GLP1RA
#MedEd #MedSky #NephSky
www.slideshare.net/slideshow/ne...
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on #Kidney Disease in people with #diabetes #flozin #sglt2i #MRA #GLP1RA
#MedEd #MedSky #NephSky
www.slideshare.net/slideshow/ne...
November 11, 2024 at 2:07 PM
Reposted
ICYMI: Stability of clinical prediction models
We raise the concern that many models exhibit instability in the model and its predictions - and recommend instability plots should be presented
-> tinyurl.com/tjnddxr8
#StatsSky #statistics #machinelearning #EpiSky
We raise the concern that many models exhibit instability in the model and its predictions - and recommend instability plots should be presented
-> tinyurl.com/tjnddxr8
#StatsSky #statistics #machinelearning #EpiSky
November 11, 2024 at 3:04 PM
ICYMI: Stability of clinical prediction models
We raise the concern that many models exhibit instability in the model and its predictions - and recommend instability plots should be presented
-> tinyurl.com/tjnddxr8
#StatsSky #statistics #machinelearning #EpiSky
We raise the concern that many models exhibit instability in the model and its predictions - and recommend instability plots should be presented
-> tinyurl.com/tjnddxr8
#StatsSky #statistics #machinelearning #EpiSky
Reposted
Another #MedSky #Skeetorial
Iron deficiency is relatively frequent and seen by all types of physicians.
For years, iron supplements were given multiple times a day.
Now we know that should never happen.
So why the change?
1/n
Iron deficiency is relatively frequent and seen by all types of physicians.
For years, iron supplements were given multiple times a day.
Now we know that should never happen.
So why the change?
1/n
November 9, 2024 at 2:00 PM
Another #MedSky #Skeetorial
Iron deficiency is relatively frequent and seen by all types of physicians.
For years, iron supplements were given multiple times a day.
Now we know that should never happen.
So why the change?
1/n
Iron deficiency is relatively frequent and seen by all types of physicians.
For years, iron supplements were given multiple times a day.
Now we know that should never happen.
So why the change?
1/n
Reposted
#NephSky
🎯Target emulation trial, nationwide 🏴
❓To stop vs not metformin in patients with DM type2 and incident eGFR<30ml/min?
⛔stopping metformin- associated with ⬇️ 3-year survival HR 1.26, 95% CI 1.10 to 1.44
⚖️No difference in MACE
🚫Limitation: residual confounding
www.ajkd.org/article/S027...
🎯Target emulation trial, nationwide 🏴
❓To stop vs not metformin in patients with DM type2 and incident eGFR<30ml/min?
⛔stopping metformin- associated with ⬇️ 3-year survival HR 1.26, 95% CI 1.10 to 1.44
⚖️No difference in MACE
🚫Limitation: residual confounding
www.ajkd.org/article/S027...
DEFINE_ME
www.ajkd.org
November 11, 2024 at 10:38 AM
#NephSky
🎯Target emulation trial, nationwide 🏴
❓To stop vs not metformin in patients with DM type2 and incident eGFR<30ml/min?
⛔stopping metformin- associated with ⬇️ 3-year survival HR 1.26, 95% CI 1.10 to 1.44
⚖️No difference in MACE
🚫Limitation: residual confounding
www.ajkd.org/article/S027...
🎯Target emulation trial, nationwide 🏴
❓To stop vs not metformin in patients with DM type2 and incident eGFR<30ml/min?
⛔stopping metformin- associated with ⬇️ 3-year survival HR 1.26, 95% CI 1.10 to 1.44
⚖️No difference in MACE
🚫Limitation: residual confounding
www.ajkd.org/article/S027...
Reposted
In Lancet ID www.thelancet.com/journals/lan... Shiranee Sriskandan & I discuss what observational data can & can't tell us about anti-toxin therapy in Invasive Group A Strep & why we need to find ways to deliver trials that can truly answer these questions. @drtoddlee.bsky.social
Time to turn off the toxins: adjuvant suppression of group A streptococcus
Streptococcus pyogenes, or group A streptococcus, remains a major global pathogen,
responsible for a wide spectrum of diseases ranging from pharyngitis to severe invasive
group A streptococcus (iGAS) ...
www.thelancet.com
October 11, 2024 at 6:47 AM
In Lancet ID www.thelancet.com/journals/lan... Shiranee Sriskandan & I discuss what observational data can & can't tell us about anti-toxin therapy in Invasive Group A Strep & why we need to find ways to deliver trials that can truly answer these questions. @drtoddlee.bsky.social
Reposted
💉Extended infusion vs intermittent infusion of betalactams for febrile neutropenia: 🤼♀️ draw0️⃣➖️0️⃣
#IDSky
#IDSky
Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomised, multicentre, open-label, superiority clinical trial
www.clinicalmicrobiologyandinfection.com/article/S119...
www.clinicalmicrobiologyandinfection.com/article/S119...
DEFINE_ME
www.clinicalmicrobiologyandinfection.com
October 20, 2024 at 3:36 AM
💉Extended infusion vs intermittent infusion of betalactams for febrile neutropenia: 🤼♀️ draw0️⃣➖️0️⃣
#IDSky
#IDSky
Reposted
My first #IDSky post will be a shameless promotion of our new UTI WikiGuideline!
jamanetwork.com/journals/jam...
Of 37 questions, only 6 had enough data to fully meet criteria for a clear recommendation!
jamanetwork.com/journals/jam...
Of 37 questions, only 6 had enough data to fully meet criteria for a clear recommendation!
Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections
This consensus statement creates a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation strength.
jamanetwork.com
November 8, 2024 at 3:04 AM
My first #IDSky post will be a shameless promotion of our new UTI WikiGuideline!
jamanetwork.com/journals/jam...
Of 37 questions, only 6 had enough data to fully meet criteria for a clear recommendation!
jamanetwork.com/journals/jam...
Of 37 questions, only 6 had enough data to fully meet criteria for a clear recommendation!