Thanks a lot 😊

Thanks ☺️

Thanks ☺️

Apply and join my lab at @umeauniversitet.bsky.social 🇸🇪 and #WCMM, generously funded by #SSMF #Consolidator @vetenskapsradet.bsky.social #Cancerfonden @kawresearch.bsky.social

Thanks to all speakers, including bsky users @winklerlab.bsky.social @claudiakleinman.bsky.social @nelander-lab.bsky.social @gocastelobranco.bsky.social, the Ragnar Söderberg foundation, and co-hosts @remeseiro-lab.bsky.social, @maawim.bsky.social, and Fredrik Swartling.

High-grade gliomas integrate into neural circuits in the human brain affecting cognition, language and decreasing survival. Fascinating field!
See you at #PALS2025

Work funded by @kawresearch.bsky.social @vetenskapsradet.bsky.social #Cancerfonden #StratNeuro #Kempestiftelsen #CancerforskningsfondenNorrland

📍 @umeauniversitet.bsky.social #WCMM_Umeå

Collab with #CemalErdem @kirkebylab.bsky.social @hornblad-lab.bsky.social

With these studies we have showed that #epigenetic regulators of the #neuron-to-glioma axis can serve as actionable #targets in #GB.

Viewing neuron-glioma interactions through an epigenetic lens helped us understand how glioma cells exploit neural signals to fuel their growth.

#ARX, #GSX2 and members of the #DLX family were identified as key #TFs regulating #GABAergic related networks in #GB.

AMPAR antagonist NBQX reduces GB cell proliferation in co-culture with glutamatergic neurons, as expected. But the GABAAR antagonist picrotoxin doesn’t affect GB growth in the setting with GABAergic interneurons. This suggests #GABA signalling drives #GB growth through non-synaptic mechanisms.

#GABAergic neuron-to-glioma synapses were recently found in #DMG/#DIPG, but not #GB @michellemonje.bsky.social @tarabarron.bsky.social

Yet our ML-based analysis flagged #GABA signalling as key in #GB. Notably, we showed that #GABAergic neurons promote #GB cell proliferation in co-culture assays.