Rajat Kumar Jha
@rajat-jha.bsky.social
Biochemistry PhD candidate in @smithlabumbc.bsky.social at UMBC. Studying aminoacyl transferases. Love ⚽
Reposted by Rajat Kumar Jha
Congrats to the newly-minted Ph.D. from the @smithlabumbc.bsky.social Dr. Misti Cartwright @chemisti.bsky.social ! Way to go on an excellent thesis defense!!
August 19, 2025 at 6:07 PM
Congrats to the newly-minted Ph.D. from the @smithlabumbc.bsky.social Dr. Misti Cartwright @chemisti.bsky.social ! Way to go on an excellent thesis defense!!
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...
www.science.org
May 23, 2025 at 4:08 AM
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
Reposted by Rajat Kumar Jha
Using laboratory-evolved versions of enzymes called CASTs, researchers have achieved a long-standing goal of genome editing: inserting entire healthy genes into human cells efficiently enough for potential therapeutic applications. @isaacwitte.bsky.social @eitzingersimon.bsky.social
Evolved gene editor inserts entire genes in human cells
The new system is the first to use a DNA-mobilizing enzyme called a CRISPR-associated transposase to make targeted gene-sized edits at therapeutically useful levels in human cells.
broad.io
May 15, 2025 at 7:05 PM
Using laboratory-evolved versions of enzymes called CASTs, researchers have achieved a long-standing goal of genome editing: inserting entire healthy genes into human cells efficiently enough for potential therapeutic applications. @isaacwitte.bsky.social @eitzingersimon.bsky.social
Reposted by Rajat Kumar Jha
Here's one to add to your Friday reading list! 🚨Just in press in J. Mol. Biol.🚨: a beautiful review on the structures, mechanisms, regulation, and open questions of aminoacyl-tRNA-protein transferases by Misti and Rajat who work on amino acid transferases! Read the paper here:
tinyurl.com/mr386wsn
tinyurl.com/mr386wsn
Structure and mechanism of aminoacyl-tRNA-protein L/F- and R-transferases
The aminoacyl-tRNA-protein transferases (also known as aa-transferases) are a class of enzymes that utilize a highly conserved GCN5-related N-acetyltr…
tinyurl.com
May 16, 2025 at 12:44 PM
Here's one to add to your Friday reading list! 🚨Just in press in J. Mol. Biol.🚨: a beautiful review on the structures, mechanisms, regulation, and open questions of aminoacyl-tRNA-protein transferases by Misti and Rajat who work on amino acid transferases! Read the paper here:
tinyurl.com/mr386wsn
tinyurl.com/mr386wsn
Reposted by Rajat Kumar Jha
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:00 AM
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Reposted by Rajat Kumar Jha
So excited to get this work out there! We have been working hard to "crack the CIA code" - more to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes...
www.biorxiv.org
March 27, 2025 at 11:49 AM
So excited to get this work out there! We have been working hard to "crack the CIA code" - more to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rajat Kumar Jha
Wow. This is really stunning . www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 6:02 PM
Wow. This is really stunning . www.science.org/doi/10.1126/...
Reposted by Rajat Kumar Jha
At least some meetings essential to approving new grants by the National Institutes of Health will be back on track later this month. scim.ag/41FbfEg
NIH announces some key grant-review meetings will restart in late March
Trump policy blocking required notices has frozen reviews of thousands of grants
scim.ag
March 3, 2025 at 7:33 PM
At least some meetings essential to approving new grants by the National Institutes of Health will be back on track later this month. scim.ag/41FbfEg
Reposted by Rajat Kumar Jha
AlphaFold has achieved significant success in protein prediction, even winning a Nobel Prize. AlphaFold3 now includes predictions for different molecules. What are the current limitations in predicting RNA structure? #3DRNAStructure #AlphaFold3 doi.org/10.1107/S205...
March 4, 2025 at 3:28 PM
AlphaFold has achieved significant success in protein prediction, even winning a Nobel Prize. AlphaFold3 now includes predictions for different molecules. What are the current limitations in predicting RNA structure? #3DRNAStructure #AlphaFold3 doi.org/10.1107/S205...