Rajan Singh
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rajansingh.bsky.social
Rajan Singh
@rajansingh.bsky.social
790 followers 1.8K following 28 posts
Asst Prof (R) #unrmed 🇺🇸 #DGBIs #Microbiome
#Gut-Brain-Microbiome #NeuroGastro #DGBIs #MetabolicHealth
#SoMe ✍️ #NGMJournal #INMAssociation #GutBrainScience
Alumnus #Gastro #SGPGIMS 🇮🇳
https://scholar.google.com/citations?hl=en&user=TBjcHp8AAAAJ
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rajansingh.bsky.social
🆕🔥The Path Forward: Assessing a Pilot Competency-Based Curriculum on #DGBIs for Gastroenterology Trainees‼️ #NGMJournal 👉 onlinelibrary.wiley.com/doi/10.1111/nm… ✅DGBI education curriculum ✅Pre-&Post-individual knowledge scores 🎯Attitudes in managing DGBIs#ANMSocietyt#ESNMNM
June 12, 2025 at 4:14 PM
rajansingh.bsky.social
🆕🔥#NeuroGastroMotil
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
May 26, 2025 at 2:14 AM
rajansingh.bsky.social
🚨The Red Section: How I Approach it
✅The Management of #Gastroparesis Symptoms‼️
@amcollegegastro.bsky.social 🆕🔥
🎯Practical approaches to managing gastroparesis👏
✳️Choice of therapy in gastroparesis based on possible #pathophysiolocal correlates
✳️Dietary management👏
👉
journals.lww.com/ajg/citation...
🎯#Practical approaches to managing gastroparesis👏 #BMoshiree #joytorious #DoerflerBethany #MichaelCline🎉 ✳️Choice of therapy in gastroparesis based on possible #pathophysiolocal correlates ✅Dietary management ⏩#Nutrient drinks commonly used in gastroparesis👏 🎯Healthy diet & tips to reduce particle size in gastroparesis💡 🎯Red flags for disordered eating behaviors 🎯Alternate diagnoses to gastroparesis✨ #ViceralHypersensitivity #PyloricDysfunction #ImpairedGastricAccomodation #DecreasedAntralContractility #VagalNerveDysfunction⚡️
February 4, 2025 at 2:08 PM
rajansingh.bsky.social
🆕🔥Yoga, Meditation, Mindfulness, or Hypnotherapy for GI disorders: Similar Mechanisms of Action?
🎯Evidence is building for mind body medicine in gut diseases‼️ @drvantilburg.bsky.social
✅Yoga, meditation & hypnotherapy may be beneficial for GI disorders👏
👉 onlinelibrary.wiley.com/doi/full/10....
• Evidence is building for mind body medicine in gut diseases. • Yoga, meditation and hypnotherapy may be beneficial because they create a deeply focused state of attention while introducing ideas or suggestions that encourage positive change. • More studies are need to examine the overlapping and shared mechanisms of mind-body approaches.
February 4, 2025 at 1:53 PM
rajansingh.bsky.social
See who is here today #UNRMed
Dr. Subhash Kulkarni @klab.bsky.social 🙏
What an amazing talk on Age-associated gut dysmotility-linking development to aging👏
🎯ENS plasticity-Replacing the ENS through neurogenesis
So much learning in the field😇
Thanks a bunch for sharing ENS insights #Halloween mouse🔥
January 31, 2025 at 6:03 AM
rajansingh.bsky.social
🚨Utmost importance the food we eat & the #GutMicrobiota
we have🔥
Fascinating study #CellCellPress 🆕
🎯#Metagenome-informed metaproteomics of the human #GutMicrobiome,🦠 host, & #dietary exposome uncovers signatures of #health & #InflammatoryBowelDisease‼️
👉 www.cell.com/cell/abstrac...
#IPHOMED #IBD
Highlights • Metagenome-informed metaproteomics (MIM) concurrently assesses diet, host, and microbiome • MIM distinguishes compositional from functional dysbiosis in multiple disease contexts • MIM links host IBD cues to commensal suppression and uncovers trans-kingdom biomarkers • MIM gauges IBD-related dietary shifts, EEN compliance, and small intestinal malabsorption ⏬Dive into to learn more about how dietary-bacterial-host metagenome-informed metaproteomics #MIM assessment functionally uncovers trans-kingdom interactomes shaping #GI ecology while offering #personalized diagnostic & therapeutic insights into #MicrobiomeAssociatedDisease💡 🎯#IPHOMED (Integrated Proteo-genomics of HOst-MicrobiomE-Diet) may contribute to the decoding of the pathogenesis of microbiome-associated diseases, while unveiling promising diagnostic and therapeutic opportunities👏 ✨Benchmarking⏩In vitro, In silico, & In vivo #Disease compliance #Disease biomarkers #Therapeutics targets #Antibiotics💊 perturbation🙌
January 20, 2025 at 9:33 PM
rajansingh.bsky.social
🆕🔥Youth with #FunctionalAbdominalPainDisorders have more #Sleep disturbances. A school-based study‼️
🎯 #Youth with functional abdominal pain disorders have worse sleep ▶️Sleep disturbances are associated with #abdominal #pain👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM
Youth with functional abdominal pain disorders have worse sleep than healthy youth and sleep disturbances are associated with abdominal pain. This highlights the need for investigation of mechanisms by which sleep disturbances affect abdominal pain and vice versa.
January 12, 2025 at 4:55 PM
rajansingh.bsky.social
🆕🔥Classification of #IBS using Brain #FunctionalConnectivityStrength & #MachineLearning‼️ #NGMJournal
🎯A unique pattern of #FCS alterations in brain areas governs #Pain regulation & #Emotional processing in IBS patients
👉 onlinelibrary.wiley.com/doi/10.1111/...
#GutBrain🧠Axis #fMRI
#ANMS #ESNM
Summary The research employs resting-state functional mag- netic resonance imaging (fMRI) to assess brain function in Irritable Bowel Syndrome (IBS) patients noninvasively. A unique pattern of FCS alterations in brain areas govern pain regulation and emotional processing in IBS patients The identified abnormal FCS features have the potential to serve as effective biomarkers for IBS classification.
January 9, 2025 at 2:31 PM
rajansingh.bsky.social
🆕🔥 #NGMJournal
✳️Changes in the #Pannexin Channel in Ileum Myenteric Plexus & Intestinal Motility Following Ischemia & Reperfusion‼️
🎯Pannexin channel blockage by probenecid is effective in attenuating the effects of I/R damage👏
👉 onlinelibrary.wiley.com/doi/full/10....
#ANMS #ESNM
Summary Intestinal ischemia and reperfusion causes intestinal damage as a whole. Here, we demonstrate that this condition also affects enteric neurons that control intestinal motility. The pannexin-1 channel is a membrane protein important in cellular communication and also in controlling ATP levels. In this work, we treated animals subjected to ischemia and reperfusion with probenecid, a pannexin-1 inhibitor. PB was able to attenuate the harmful effects of I/R, recovering the number of enteric neurons and improving intestinal motility.
January 8, 2025 at 2:44 PM
rajansingh.bsky.social
Excellent review @naturerevmicro.bsky.social 🆕🔥
🚨Microbiota🦠–neuroepithelial signalling across the #Gut–#Brain axis‼️
#GutConnectome🔁#BrainConnectome🧠
👉 www.nature.com/articles/s41...
✅Most recent advances in pathways that connect the gut & brain🧠
#DGBIs #Neuropsychiatric health #Serotonin #GLP-1
✳️So much to learn in the field😇 ✅Most recent advances in pathways that connect the gut & brain🧠 ⏩Complex dialogue between microorganisms & neurons at intestinal #neuroepithelial interface👏 🎯#Microbial factors, #endocrine cells & neural mechanisms that govern Gut microbiota–Brain interactions💡 💊Potential of microbiota-based therapies targeting intestinal neuroepithelial pathways✨ #DGBIs #Neuropsychiatric health #GutSensory system #Serotonin #GLP-1
January 4, 2025 at 6:30 PM
rajansingh.bsky.social
🆕🔥Global epidemiology study shows symptom differences within 5 most common #DGBIs based on #sex #menopause #age & #menses‼️ #NGMJournal
🎯Sex hormone-mediated effects may contribute to ⏫symptom burden in women than men with #DGBI👏
👉 onlinelibrary.wiley.com/doi/epdf/10....
#ANMS #ESNM
Our global epidemiological study showed sex differences in individual disorders of gut–brain interaction(DGBI) symptoms, where women experienced higher prevalence in the vast majority of symptoms. This may indicate sex-specific abnormal regulation in women that increases symptoms compared to men. We found that both premenopausal women and comparably aged younger men tended to have greater symptom burden compared to their older counter-parts, which supports that there is an age effect on DGBI symptoms that is possibly independent of sex. Some indicators of visceral perception were increased in premenopausal women compared to postmenopausal women, and others of outlet dysfunction were increased in postmenopausal compared to premenopausal women, both of which differences were not shared by men. This, together with our finding that menses-related symptoms tend to be most bothersome and most co-morbid in pain-predominant DGBI (irritable bowel syndrome and functional dyspepsia), suggests that sex hormone-mediated effects on visceral perception and GI function may contribute to a greater symptom burden in women than men with DGBI.
January 4, 2025 at 5:04 AM
rajansingh.bsky.social
Excellent review🆕🔥Chemotherapy-induced neuropathy affecting the #GI tract‼️
✳️Most recent advances⏩#Neurotoxic effects of #chemotherapy on #ENS & #gut extrinsic innervation
🎯Long-term GI dysfunctions #Gut–brain🧠axis disorders
👉https://onlinelibrary.wiley.com/doi/10.1111/nmo.14976
#ANMSociety #esnm_eu
• Cancer survivorship is increasing, thanks to early detection, more effective therapies, and supportive care, but sequelae of treatment may occur in the long term in these patients. • Chemotherapy (with/without immunotherapy/radiotherapy) may induce neurotoxic effects on the gastrointestinal innervation. • Chemotherapy-induced enteric neuropathy (CIEN) and, probably, neurotoxicity affecting the extrinsic innervation of the gut and the brain underlie the frequent and impactful gut dysfunctions and brain–gut axis (BGA) disorders occurring in the long term in cancer survivors.
December 21, 2024 at 5:16 PM
rajansingh.bsky.social
🆕🔥Elevated #FecalBiomarkers of colo‐rectal #EpithelialCell activity in #IBS‼️ #NGMJournal
🎯Activity of #GutEpithelialCells rather than #inflammation driven by #neutrophils and/or #eosinophils, is a key #pathogenetic mechanism in #IBS👏
👉https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.14984
✅The measurement in feces of a panel of biomarkers reflecting inflammatory and epithelial cell activities is important for understanding the underlying pathophysiology of IBS. ✅The absence of signs of involvement of neutrophils and eosinophils in IBS suggests that increased activity of intestinal epithelial cells rather than inflammation is a major determinant of the disease. ✅The negative correlation between the novel biomarker human phospholipase BII-precursor (HPLBII-P) and bloating and the presence of this biomarker in intestinal epithelial cells suggest a physiological role of HPLBII-P in intestinal activities.
December 17, 2024 at 2:40 PM
rajansingh.bsky.social
Genome-Wide DNA #Methylation identifies potential disease-specific #biomarkers & #pathophysiologic mechanisms in #IBS #IBD & #CeliacDisease‼️ #NGMJournal🆕🔥
🎯#CellAdhesion & #Neuronal pathways ⏩IBS
🎯#Inflammation ⏩IBD
🎯MHC class II pathways ⏩CeD
👉https://onlinelibrary.wiley.com/doi/10.1111/nmo.14980👏
1. Blood-based DNA methylation biomarkers show promise in distinguishing between gastrointestinal (GI) disorders with overlapping symptoms, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease, and in differentiating these conditions from healthy individuals, thus offering a novel diagnostic approach for these GI disorders. 2. Gene ontology analysis identified distinct pathways associated with each disorder, such as cell adhesion and neuronal pathways for IBS, inflammation for IBD, and MHC class II pathways for celiac disease, underscoring the biological relevance of these biomarkers.
December 15, 2024 at 5:20 PM
rajansingh.bsky.social
📢Elegant study @gastroenterology.bsky.social 🆕🔥
Intestinal Epithelial #Serotonin as a Novel Target for Treating #DGBI & #Mood‼️ #GutConnectome🔁#BrainConnectome🧠#Serotonin
@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social
🎉
👉https://www.gastrojournal.org/article/S0016-5085(24)05751-2/fulltext
✳️The most recent advances into how the #GI tract modulates #EmotionalBehaviors ⏩A novel #gut-targeted therapeutic approach for mood modulation ⏩A new link in humans between in utero #SSRI exposure & #DGBI development👏 ▶️Targeted deletion of the #SERT in the intestinal epithelium reduced #anxiety & #depressive-like behaviors✨ ▶️Increased serotonin in the gut epithelium is #anxiolytic & anti-depressive which is mediated through #vagal signaling 🎯 ▶️Maternal #SSRI exposure is associated with a risk of developing #constipation in the first year of life⚡️
December 12, 2024 at 2:43 PM
rajansingh.bsky.social
Fascinating study@natureportfolio.bsky.social🆕🔥
✳️Organ-specific #sympathetic innervation defines visceral functions‼️ #GutFunctions
⏬Dive into to learn more about how brain🧠 controls visceral organs through #brain-to-body sympathetic signals
www.nature.com/articles/s41...
#GutBrainScience #GastroSky
November 30, 2024 at 3:32 AM
rajansingh.bsky.social
🚨Elegant study! @science.org 🆕🔥
✳️ #PIEZO-dependent #mechanosensing is essential for intestinal #stem cell fate decision and maintenance‼️
👉 www.science.org/doi/10.1126/...
#GutScience #GISky #GastroSky
November 30, 2024 at 2:52 AM
rajansingh.bsky.social
📢Utmost importance the #food we eat & the #GutMicrobiota we have‼️
👉#Gut #physiology & #environment explain variations in human gut #microbiome🦠 composition & #metabolism🆕🔥
@naturemicrobiol.bsky.social
🔍Zoom in to uncover the insights within
👉https://www.nature.com/articles/s41564-024-01856-x
November 29, 2024 at 4:24 PM
rajansingh.bsky.social
#Interoception & #Gut–#Brain🧠 communication‼️
🔊Fascinating Primer @currentbiology.bsky.social🆕🔥
👉https://www.cell.com/current-biology/fulltext/S0960-9822(24)01389-7
✳️Origins of interoception research & how body–brain interactions govern our most critical homeostatic functions⏩From #Motility to #Mood🎯
#GastroSky #GISky #GutBrainScience
November 25, 2024 at 1:01 AM
rajansingh.bsky.social
#Gut–#Brain🧠axis #Pain signalling mechanisms in #GI tract‼️ #GutPain
✅Most recent advances on molecular communication between non-neuronal cell types & #neurons in #VisceralPain
🎯Huge potential of #Neuromodulation in #DGBIs👏
👉https://nature.com/articles/s41575-024-01017-9
@natrevgastrohep.bsky.social
November 23, 2024 at 3:12 AM