🧠 New PubMed Article Alert!
Corrigendum to "Neurogranin binds alpha-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease" [Brain Res. 1591 (2014) 102-110].
https://pubmed.ncbi.nlm.nih.gov/39947974/
#neurodegeneration #Parkinsons #alphasynuclein
Corrigendum to "Neurogranin binds alpha-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease" [Brain Res. 1591 (2014) 102-110].
https://pubmed.ncbi.nlm.nih.gov/39947974/
#neurodegeneration #Parkinsons #alphasynuclein
March 15, 2025 at 2:53 PM
🧠 New PubMed Article Alert!
Corrigendum to "Neurogranin binds alpha-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease" [Brain Res. 1591 (2014) 102-110].
https://pubmed.ncbi.nlm.nih.gov/39947974/
#neurodegeneration #Parkinsons #alphasynuclein
Corrigendum to "Neurogranin binds alpha-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease" [Brain Res. 1591 (2014) 102-110].
https://pubmed.ncbi.nlm.nih.gov/39947974/
#neurodegeneration #Parkinsons #alphasynuclein
StressMarq's fibrillar, oligomeric and monomeric #AlphaSynuclein, #Tau & #AmyloidBeta proteins are frequently cited in leading scientific journals.
Learn how our innovative tools for #neurodegenerative disease research are being used around the world 👉 bit.ly/43nfzJm
Learn how our innovative tools for #neurodegenerative disease research are being used around the world 👉 bit.ly/43nfzJm
Product Citations for Neurodegenerative Proteins
StressMarq’s alpha synuclein, tau amyloid beta proteins for neurodegenerative disease research have been cited in many peer-reviewed scientific journals.
bit.ly
March 18, 2025 at 9:06 PM
StressMarq's fibrillar, oligomeric and monomeric #AlphaSynuclein, #Tau & #AmyloidBeta proteins are frequently cited in leading scientific journals.
Learn how our innovative tools for #neurodegenerative disease research are being used around the world 👉 bit.ly/43nfzJm
Learn how our innovative tools for #neurodegenerative disease research are being used around the world 👉 bit.ly/43nfzJm
Product Citation: A neuronal model of #Parkinson's disease was established using StressMarq's #AlphaSynuclein PFFs, to test the efficacy of the decoy peptide CS2 in mitigating αSynuclein toxicity.
Paper 🗞️ bit.ly/4bIQx9Y
Product 🌱 bit.ly/2u9YHV2
Paper 🗞️ bit.ly/4bIQx9Y
Product 🌱 bit.ly/2u9YHV2
March 26, 2025 at 11:24 PM
Product Citation: A neuronal model of #Parkinson's disease was established using StressMarq's #AlphaSynuclein PFFs, to test the efficacy of the decoy peptide CS2 in mitigating αSynuclein toxicity.
Paper 🗞️ bit.ly/4bIQx9Y
Product 🌱 bit.ly/2u9YHV2
Paper 🗞️ bit.ly/4bIQx9Y
Product 🌱 bit.ly/2u9YHV2
Using StressMarq's #BetaSynuclein, #GammaSynuclein & #AmyloidBeta 1-42 PFFs, scientists developed a quiescent seed amplification assay (QSAA) to detect #AlphaSynuclein aggregates in #cerebrospinal fluid & #skin samples.
Read about it on the blog! https://bit.ly/43QvnTN
Read about it on the blog! https://bit.ly/43QvnTN
Optimizing Alpha Synuclein Seed Amplification Assays
Seed amplification assays detect abnormal forms of alpha synuclein. An improved quiescent SAA method streamlines this process and maintains tissue integrity.
bit.ly
June 12, 2025 at 4:46 PM
Using StressMarq's #BetaSynuclein, #GammaSynuclein & #AmyloidBeta 1-42 PFFs, scientists developed a quiescent seed amplification assay (QSAA) to detect #AlphaSynuclein aggregates in #cerebrospinal fluid & #skin samples.
Read about it on the blog! https://bit.ly/43QvnTN
Read about it on the blog! https://bit.ly/43QvnTN
A collaboration between ABL Bio Inc., Sanofi, USC, UCSD, and the National Research Council Canada utilized StressMarq's #AlphaSynuclein PFFs & Monomers to investigate an alpha synuclein antibody engineered for effective delivery across the blood-brain barrier.🩸
Read the blog! bit.ly/3SrWbV8 🌟
Read the blog! bit.ly/3SrWbV8 🌟
Bispecific Antibodies for the Treatment of Synucleinopathies
A bispecific antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies was engineered to effectively cross the blood-brain barrier.
bit.ly
May 28, 2025 at 8:54 PM
A collaboration between ABL Bio Inc., Sanofi, USC, UCSD, and the National Research Council Canada utilized StressMarq's #AlphaSynuclein PFFs & Monomers to investigate an alpha synuclein antibody engineered for effective delivery across the blood-brain barrier.🩸
Read the blog! bit.ly/3SrWbV8 🌟
Read the blog! bit.ly/3SrWbV8 🌟
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
November 22, 2024 at 9:50 AM
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
Product Citation: Scientists probed the correlation between age-related macular degeneration (AMD) & the development of #Parkinson's disease, using StressMarq's #AlphaSynuclein Pre-formed Fibrils.
Paper 🗯️ bit.ly/44nXQlw
Product details 📬 bit.ly/2u9YHV2
Paper 🗯️ bit.ly/44nXQlw
Product details 📬 bit.ly/2u9YHV2
April 16, 2025 at 11:48 PM
Product Citation: Scientists probed the correlation between age-related macular degeneration (AMD) & the development of #Parkinson's disease, using StressMarq's #AlphaSynuclein Pre-formed Fibrils.
Paper 🗯️ bit.ly/44nXQlw
Product details 📬 bit.ly/2u9YHV2
Paper 🗯️ bit.ly/44nXQlw
Product details 📬 bit.ly/2u9YHV2
Voice deficits are common in Parkinson's disease & significantly impact quality of life. Now, Brooke Rodgers & Allison Schaser show that overexpression of alpha-synuclein alone does not result in significant vocalisation deficits. doi.org/10.1242/bio....
#Parkinsonism #AlphaSynuclein
#Parkinsonism #AlphaSynuclein
![USV results averaged over each genotype group (GFP+, A53T SynGFP+; WT, wild type), pooled across sex. Results for simple (left column) and complex (right column) USVs were analyzed and plotted separately as total USV count (A,B), duration (D,E), frequency range (F,G), and maximum intensity (H,I). Group averages for USV complexity ratio are shown in C. Error bars represent the standard error of the mean value (s.e.m.) and points depict values for individual animals. The asterisk above the bars in plot B indicate a statistically significant difference between the group means observed in the analysis of deviance model [Pr(>χ2)<0.05].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ckg56sce76vdnqq4yhdlfbts/bafkreidakyi65skzojcd72yjbg32i4frrxv4kyu7wk2z6mvju5j3766y3i@jpeg)
November 7, 2025 at 5:01 PM
Voice deficits are common in Parkinson's disease & significantly impact quality of life. Now, Brooke Rodgers & Allison Schaser show that overexpression of alpha-synuclein alone does not result in significant vocalisation deficits. doi.org/10.1242/bio....
#Parkinsonism #AlphaSynuclein
#Parkinsonism #AlphaSynuclein
Product Citation 🌟 A research team @mayoclinic.org investigated mechanisms driving #LewyBody pathology using a novel split biotin ligase technique. StressMarq’s #AlphaSynuclein PFFs were employed to model aggregation in vitro.
Paper 🌿https://bit.ly/4hB0VDy
Product 🌼 https://bit.ly/2u9YHV2
Paper 🌿https://bit.ly/4hB0VDy
Product 🌼 https://bit.ly/2u9YHV2
October 30, 2025 at 4:46 PM
Product Citation 🌟 A research team @mayoclinic.org investigated mechanisms driving #LewyBody pathology using a novel split biotin ligase technique. StressMarq’s #AlphaSynuclein PFFs were employed to model aggregation in vitro.
Paper 🌿https://bit.ly/4hB0VDy
Product 🌼 https://bit.ly/2u9YHV2
Paper 🌿https://bit.ly/4hB0VDy
Product 🌼 https://bit.ly/2u9YHV2
Have been reading about the history of toxic oligomers of #alphasynuclein and #Abeta the past few days. As far as I can tell, this whole story originated from observations for in vitro assembly of recombinant protein, which has now been shown to yield disease-irrelevant filaments.
March 14, 2025 at 4:20 PM
Have been reading about the history of toxic oligomers of #alphasynuclein and #Abeta the past few days. As far as I can tell, this whole story originated from observations for in vitro assembly of recombinant protein, which has now been shown to yield disease-irrelevant filaments.
Scientists employed StressMarq's #AlphaSynuclein Pre-formed Fibrils & Monomers and Anti-Amyloid Antibodies to examine biofilm-associated protein (BAP) amyloids in gut #microbiota.
Read more about the study on the blog 🔎: bit.ly/49KH4O7
Read more about the study on the blog 🔎: bit.ly/49KH4O7
Pathogenic Amyloid Fibrils Produced by Gut Microbiota
BAPs form amyloid-like insoluble fibrils in the gut, which correlated with alpha synuclein aggregation and neurodegenerative symptoms in vitro and in vivo.
bit.ly
February 5, 2025 at 7:05 PM
Scientists employed StressMarq's #AlphaSynuclein Pre-formed Fibrils & Monomers and Anti-Amyloid Antibodies to examine biofilm-associated protein (BAP) amyloids in gut #microbiota.
Read more about the study on the blog 🔎: bit.ly/49KH4O7
Read more about the study on the blog 🔎: bit.ly/49KH4O7
StressMarq's Mouse #AlphaSynuclein Pre-formed Fibrils were successfully used in vitro & in vivo to illustrate the protective effects of a NADPH oxidase (NOX) inhibitor in models of #Parkinson's disease pathology.
Learn more about the study on the blog 💡 bit.ly/3QvwYYR
Learn more about the study on the blog 💡 bit.ly/3QvwYYR
Treating Alpha Synuclein Pathology with NOX Inhibitors
Compound-11 is an NADPH oxidase (NOX) inhibitor that reduces alpha synuclein aggregation & increases cell viability in Parkinson's disease pathology.
bit.ly
February 22, 2025 at 12:07 AM
StressMarq's Mouse #AlphaSynuclein Pre-formed Fibrils were successfully used in vitro & in vivo to illustrate the protective effects of a NADPH oxidase (NOX) inhibitor in models of #Parkinson's disease pathology.
Learn more about the study on the blog 💡 bit.ly/3QvwYYR
Learn more about the study on the blog 💡 bit.ly/3QvwYYR
The May edition of "What's New at StressMarq?" is now available! Learn more about how our #AlphaSynuclein A90C Monomers & #Tau PFFs are being used in #neurodegenerative disease models, check out our new #recombinant antibodies, and read our latest blog posts.📨
Check it out 📬 bit.ly/3Sxzajq
Check it out 📬 bit.ly/3Sxzajq
What's New at StressMarq?
bit.ly
May 14, 2025 at 4:54 PM
The May edition of "What's New at StressMarq?" is now available! Learn more about how our #AlphaSynuclein A90C Monomers & #Tau PFFs are being used in #neurodegenerative disease models, check out our new #recombinant antibodies, and read our latest blog posts.📨
Check it out 📬 bit.ly/3Sxzajq
Check it out 📬 bit.ly/3Sxzajq
'Modulation of O-GlcNAc cycling influences α-#synuclein amplification, degradation, and associated #neuroinflammatory pathology'
Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein
molecularneurodegeneration.biomedcentral.com/articles/10....
Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein
molecularneurodegeneration.biomedcentral.com/articles/10....
Modulation of O-GlcNAc cycling influences α-synuclein amplification, degradation, and associated neuroinflammatory pathology - Molecular Neurodegeneration
Background The accumulation and propagation of α-synuclein (α-syn) are hallmark features of Parkinson’s disease (PD) and related neurodegenerative disorders. O-GlcNAcylation, an abundant post-translat...
molecularneurodegeneration.biomedcentral.com
October 27, 2025 at 5:17 PM
'Modulation of O-GlcNAc cycling influences α-#synuclein amplification, degradation, and associated #neuroinflammatory pathology'
Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein
molecularneurodegeneration.biomedcentral.com/articles/10....
Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein
molecularneurodegeneration.biomedcentral.com/articles/10....
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
November 25, 2024 at 7:17 AM
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
November 22, 2024 at 10:29 AM
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
Product Citation: Using a 3D human bidirectional gut-brain model and StressMarq's #AlphaSynuclein PFFs, researchers induced neuroinflammatory processes in order to observe gut-brain signaling pathways.
Paper 🌟 bit.ly/3Y0dzDi
Product 🌤️ bit.ly/2u9YHV2
Paper 🌟 bit.ly/3Y0dzDi
Product 🌤️ bit.ly/2u9YHV2
March 26, 2025 at 11:25 PM
Product Citation: Using a 3D human bidirectional gut-brain model and StressMarq's #AlphaSynuclein PFFs, researchers induced neuroinflammatory processes in order to observe gut-brain signaling pathways.
Paper 🌟 bit.ly/3Y0dzDi
Product 🌤️ bit.ly/2u9YHV2
Paper 🌟 bit.ly/3Y0dzDi
Product 🌤️ bit.ly/2u9YHV2
🧠 Oligomeric #AlphaSynuclein, #Tau & #AmyloidBeta proteins have emerged as key players in #neurodegenerative diseases. Explore how StressMarq's high-quality oligomeric protein constructs, cited in top-tier research, are advancing pre-clinical drug discovery & disease models: https://bit.ly/4kE2Xn0.
June 17, 2025 at 10:17 PM
🧠 Oligomeric #AlphaSynuclein, #Tau & #AmyloidBeta proteins have emerged as key players in #neurodegenerative diseases. Explore how StressMarq's high-quality oligomeric protein constructs, cited in top-tier research, are advancing pre-clinical drug discovery & disease models: https://bit.ly/4kE2Xn0.
Product Citation: Proteomic analysis identified pyroxamide as a potential #neuroprotective agent in Parkinson's disease. StressMarq's #AlphaSynuclein A53T PFFs were used to examine its effects in an in vitro model of #PD.
Paper 💡 https://bit.ly/46XxV3O ##αSyn PFFs 🌐 https://bit.ly/2GREQ4c
Paper 💡 https://bit.ly/46XxV3O ##αSyn PFFs 🌐 https://bit.ly/2GREQ4c
October 7, 2025 at 11:09 PM
Product Citation: Proteomic analysis identified pyroxamide as a potential #neuroprotective agent in Parkinson's disease. StressMarq's #AlphaSynuclein A53T PFFs were used to examine its effects in an in vitro model of #PD.
Paper 💡 https://bit.ly/46XxV3O ##αSyn PFFs 🌐 https://bit.ly/2GREQ4c
Paper 💡 https://bit.ly/46XxV3O ##αSyn PFFs 🌐 https://bit.ly/2GREQ4c
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
November 25, 2024 at 6:52 AM
#alphasynuclein aggregates in Parkinson’s and MSA are potential drug targets. Researchers @mpi_bpc and @DZNE_DE have now investigated aggregates from patient tissue for the first time – with surprising findings. https://www.mpibpc.mpg.de/17136602/pr_1929
#Parkinson #MultipleSystemAtrophy
#Parkinson #MultipleSystemAtrophy
The N-terminal region of #AlphaSynuclein significantly affects its propensity to aggregate in #Parkinson's disease & other synucleinopathies. A cutting-edge Alpha Synuclein N-terminal Antibody is now available from StressMarq Biosciences.💫
Product details 🔬 bit.ly/3EVFTke
Product details 🔬 bit.ly/3EVFTke
Anti-Alpha Synuclein N-terminal Antibody [11D4] Mouse Monoclonal
Alpha Synuclein N-terminal Antibody- Mouse monoclonal antibody to human Alpha Synuclein N-terminal, clone 11D4. Validated for WB, IHC with human, mouse, rat tissue.
bit.ly
May 16, 2025 at 4:53 PM
The N-terminal region of #AlphaSynuclein significantly affects its propensity to aggregate in #Parkinson's disease & other synucleinopathies. A cutting-edge Alpha Synuclein N-terminal Antibody is now available from StressMarq Biosciences.💫
Product details 🔬 bit.ly/3EVFTke
Product details 🔬 bit.ly/3EVFTke
🆕🔥#NeuroGastroMotil
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
May 26, 2025 at 2:14 AM
🆕🔥#NeuroGastroMotil
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
Investigators developed a unique peptide-based fluorescent probe for the rapid and specific labelling of alpha synuclein aggregates, using StressMarq's Mouse #AlphaSynuclein PFFs.
Full paper👉 https://bit.ly/4aqc45Y
α-Syn Pre-formed Fibrils: https://bit.ly/2HJyYee
Full paper👉 https://bit.ly/4aqc45Y
α-Syn Pre-formed Fibrils: https://bit.ly/2HJyYee
September 19, 2025 at 11:17 PM
Investigators developed a unique peptide-based fluorescent probe for the rapid and specific labelling of alpha synuclein aggregates, using StressMarq's Mouse #AlphaSynuclein PFFs.
Full paper👉 https://bit.ly/4aqc45Y
α-Syn Pre-formed Fibrils: https://bit.ly/2HJyYee
Full paper👉 https://bit.ly/4aqc45Y
α-Syn Pre-formed Fibrils: https://bit.ly/2HJyYee
Researchers have demonstrated that synthetic peptides can inhibit toxic #AlphaSynuclein fibrils & reduce #OxidativeStress. These dual-function peptides offer a promising therapeutic strategy for #Parkinson’s disease.
Read about the study on the blog 🛋️ https://bit.ly/4kUuik0
Read about the study on the blog 🛋️ https://bit.ly/4kUuik0
Alpha Synuclein Inhibition Using Biomimetic Peptides
Dual-function biomimetic peptides inhibited fibrillization & aggregation of alpha synuclein and exhibited antioxidant properties in a Parkinson's disease model.
bit.ly
July 27, 2025 at 7:46 PM
Researchers have demonstrated that synthetic peptides can inhibit toxic #AlphaSynuclein fibrils & reduce #OxidativeStress. These dual-function peptides offer a promising therapeutic strategy for #Parkinson’s disease.
Read about the study on the blog 🛋️ https://bit.ly/4kUuik0
Read about the study on the blog 🛋️ https://bit.ly/4kUuik0