#AlphaSynuclein
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biologyopen.bsky.social
Voice deficits are common in Parkinson's disease & significantly impact quality of life. Now, Brooke Rodgers & Allison Schaser show that overexpression of alpha-synuclein alone does not result in significant vocalisation deficits. doi.org/10.1242/bio....

#Parkinsonism #AlphaSynuclein
USV results averaged over each genotype group (GFP+, A53T SynGFP+; WT, wild type), pooled across sex. Results for simple (left column) and complex (right column) USVs were analyzed and plotted separately as total USV count (A,B), duration (D,E), frequency range (F,G), and maximum intensity (H,I). Group averages for USV complexity ratio are shown in C. Error bars represent the standard error of the mean value (s.e.m.) and points depict values for individual animals. The asterisk above the bars in plot B indicate a statistically significant difference between the group means observed in the analysis of deviance model [Pr(>χ2)<0.05].
November 7, 2025 at 5:01 PM
stressmarq.bsky.social
Product Citation 🌟 A research team @mayoclinic.org investigated mechanisms driving #LewyBody pathology using a novel split biotin ligase technique. StressMarq’s #AlphaSynuclein PFFs were employed to model aggregation in vitro.

Paper 🌿https://bit.ly/4hB0VDy
Product 🌼 https://bit.ly/2u9YHV2
October 30, 2025 at 4:46 PM
rpeptide.bsky.social
Our Alpha-Synuclein Preformed Fibrils can also help those wishing to shortcut the fibrillization process, saving valuable time and resources. We are excited to support innovative research working to stop neurodegeneration at its source.

t.ly/cAaI5

#Fibrils #Recombinant #AlphaSynuclein #rPeptide
Alpha-Synuclein Preformed Fibrils
Alpha-Synuclein Preformed Fibrils from rPeptide. In stock and ready to ship. High purity, batch to batch consistency. Order online today.
t.ly
October 29, 2025 at 12:32 PM
molneurodegen.bsky.social
'Modulation of O-GlcNAc cycling influences α-#synuclein amplification, degradation, and associated #neuroinflammatory pathology'

Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein

molecularneurodegeneration.biomedcentral.com/articles/10....
Modulation of O-GlcNAc cycling influences α-synuclein amplification, degradation, and associated neuroinflammatory pathology - Molecular Neurodegeneration
Background The accumulation and propagation of α-synuclein (α-syn) are hallmark features of Parkinson’s disease (PD) and related neurodegenerative disorders. O-GlcNAcylation, an abundant post-translat...
molecularneurodegeneration.biomedcentral.com
October 27, 2025 at 5:17 PM
stressmarq.bsky.social
A collaborative study between @ucl.ac.uk, @crick.ac.uk, and KAIST examined how astrocytes shift to neurotoxic states in #Parkinson’s disease, with #AlphaSynuclein and ADAR1 RNA editing driving inflammation.

Read about it on the blog📚 http://bit.ly/4qmdXc3
October 22, 2025 at 5:04 PM
stressmarq.bsky.social
Product Citation: Coordination of #Anle138b with silver yields a novel compound that selectively reduces C-terminally truncated αSyn in a Parkinson's disease model employing StressMarq’s #AlphaSynuclein PFFs.

Paper 🏝️ https://bit.ly/3KKfR62
Product 🌊 https://bit.ly/2u9YHV2
##neurodegeneration
October 16, 2025 at 8:41 PM
stressmarq.bsky.social
Product Citation: Proteomic analysis identified pyroxamide as a potential #neuroprotective agent in Parkinson's disease. StressMarq's #AlphaSynuclein A53T PFFs were used to examine its effects in an in vitro model of #PD.

Paper 💡 https://bit.ly/46XxV3O ##αSyn PFFs 🌐 https://bit.ly/2GREQ4c
October 7, 2025 at 11:09 PM
getnews-me.bsky.social
Researchers used ASA‑PD fluorescence to see alpha‑synuclein oligomers in brains, finding larger clusters in Parkinson’s patients than in controls. Read more: https://getnews.me/scientists-visualize-parkinsons-alpha-synuclein-oligomers-in-brain/ #parkinsonsdisease #alphasynuclein
Scientists Visualize Parkinson’s Alpha‑Synuclein Oligomers in Brain
October 7, 2025 at 8:52 AM
newswise.bsky.social
Researchers Reveal Potential Molecular Link Between Air Pollutants and Increased Risk of Lewy Body Dementia
www.newswise.com/articles/res...
#lewybodydementia #fineparticulateairpollution #dementia #alzheimersdisease #NeurodegenerativeDiseases #airpollution #parkinsondisease #AlphaSynuclein
Researchers Reveal Potential Molecular Link Between Air Pollutants and Increased Risk of Lewy Body Dementia | Newswise
A team of researchers at Johns Hopkins Medicine say they have revealed a possible molecular connection between air pollution and an increased risk of developing Lewy body dementia.
www.newswise.com
October 6, 2025 at 7:43 AM
stressmarq.bsky.social
Investigators developed a unique peptide-based fluorescent probe for the rapid and specific labelling of alpha synuclein aggregates, using StressMarq's Mouse #AlphaSynuclein PFFs.

Full paper👉 https://bit.ly/4aqc45Y
α-Syn Pre-formed Fibrils: https://bit.ly/2HJyYee
September 19, 2025 at 11:17 PM
nicolekidmansnose.bsky.social
Lewy bodies are made from a protein called alphasynuclein. The protein is crucial for healthy brain functioning but can misfold in various ways to produce different kinds of harmful Lewy bodies. These can kill nerve cells, causing devastating disease by spreading.
www.theguardian.com/environment/...
Air pollution can drive devastating forms of dementia, research suggests
Airborne particles cause toxic clumps of proteins in brain that are hallmarks of Lewy body dementia, study indicates
www.theguardian.com
September 5, 2025 at 9:39 AM
rpeptide.bsky.social
To uncover these patterns, researchers used rPeptide’s wild-type Alpha-Synuclein (t.ly/fb9Hw) and Alpha-Synuclein Preformed Fibrils (t.ly/1WaMn) in RT-QuIC assays across 13 brain areas.

#Research #Development #Recombinant #Peptide #Protien #AlphaSynuclein #PreformedFibrils #rPeptide
Alpha-Synuclein Preformed Fibrils
Alpha-Synuclein Preformed Fibrils from rPeptide. In stock and ready to ship. High purity, batch to batch consistency. Order online today.
t.ly
August 27, 2025 at 12:59 PM
stressmarq.bsky.social
Product Citation: StressMarq’s #AlphaSynuclein PFFs were utilized to evaluate a novel α-synuclein-specific epitope vaccine, which demonstrated therapeutic potential by alleviating Parkinson’s disease-related pathophysiology in mouse models. #PD

Paper👉 bit.ly/3RMTC0d
α-Syn PFFs: bit.ly/2u9YHV2
August 26, 2025 at 4:49 PM
molneurodegen.bsky.social
A manifesto for #AlzheimersDisease drug discovery in the era of disease-modifying #therapies

Heike Hering, Thierry Bussiere, Chia-Chen Liu...Dominic M. Walsh #amyloid #alphasynuclein #APOE

molecularneurodegeneration.biomedcentral.com/articles/10....
August 6, 2025 at 4:09 PM
stressmarq.bsky.social
Researchers have demonstrated that synthetic peptides can inhibit toxic #AlphaSynuclein fibrils & reduce #OxidativeStress. These dual-function peptides offer a promising therapeutic strategy for #Parkinson’s disease.

Read about the study on the blog 🛋️ https://bit.ly/4kUuik0
Alpha Synuclein Inhibition Using Biomimetic Peptides
Dual-function biomimetic peptides inhibited fibrillization & aggregation of alpha synuclein and exhibited antioxidant properties in a Parkinson's disease model.
bit.ly
July 27, 2025 at 7:46 PM
stressmarq.bsky.social
Product Citation: Scientists at the NIA employed StressMarq's #AlphaSynuclein Oligomers, PFFs & Monomers to demonstrate that structurally distinct αSyn polymorphs exhibit varying #neurotoxic effects.

Paper 🔎 https://bit.ly/455xNPX | Alpha Synuclein 🌿 https://bit.ly/48w0J27
July 22, 2025 at 6:07 PM
stressmarq.bsky.social
Product Citation: Histopathological analyses revealed extensive pSer129-αSyn+ neuritic inclusions in a mouse model of #Parkinson's disease, post-injection with StressMarq's Mouse #AlphaSynuclein PFFs.

Paper 💻 https://bit.ly/4f439dh
Product details 🐭 https://bit.ly/2HJyYee
July 19, 2025 at 5:18 PM
kavlioxford.bsky.social
#Parkinsons #Neurodegeneration #AlphaSynuclein #StemCellModels #RyanLab
@wademartinslab.bsky.social
@oxforddpag.bsky.social
@medsci.ox.ac.uk
July 15, 2025 at 10:23 AM
molneurodegen.bsky.social
'Skin biopsy: an emerging tool for the diagnosis of #proteinmisfolding diseases of the central nervous system'

Wei Zhu, Hao-Lun Sun, Yan-Jiang Wang, Xia Lei, Xian-Le Bu #alphasynuclein #neurodegeneration

molecularneurodegeneration.biomedcentral.com/articles/10....
Skin biopsy: an emerging tool for the diagnosis of protein misfolding diseases of the central nervous system - Molecular Neurodegeneration
molecularneurodegeneration.biomedcentral.com
July 7, 2025 at 2:32 PM
rpeptide.bsky.social
A @nature.com article reveals a link between #neurodegenerative proteins and #HIV. #Researchers found that #AlphaSynuclein and #BetaAmyloid fibrils enhance HIV-1 entry and replication in brain cells, offering new insight into HIV-associated neurocognitive disorders.

t.ly/t5fiq

#Recombinant
α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia - Nature Communications
Here, Olari et al show that alpha-synuclein enhances HIV-1 entry and replication in human T cells, macrophages and microglia which may contribute to the development of neurodegenerative disease.
t.ly
July 2, 2025 at 2:49 PM
stressmarq.bsky.social
🧠 Oligomeric #AlphaSynuclein, #Tau & #AmyloidBeta proteins have emerged as key players in #neurodegenerative diseases. Explore how StressMarq's high-quality oligomeric protein constructs, cited in top-tier research, are advancing pre-clinical drug discovery & disease models: https://bit.ly/4kE2Xn0.
June 17, 2025 at 10:17 PM
rpeptide.bsky.social
#Researchers found that certain naturally occurring #antibodies can block the buildup and harmful effects of #AlphaSynuclein, a key protein involved in #Parkinsons Disease.

#rPeptide α-Syn products were used - the full-length #protein, and several defined fragments.

t.ly/rM9w3

α-Syn: t.ly/Kl17L
Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity
Aggregates of α-synuclein (α-Syn) are the major component of the Lewy bodies associated with Parkinson's disease. Recently, naturally occurring autoan…
t.ly
June 16, 2025 at 1:53 PM
stressmarq.bsky.social
Product Citation: IHM nanoparticles reprogram diseased microglia to degrade αSyn & reduce #neuroinflammation in #Parkinson's disease. StressMarq's Mouse #AlphaSynuclein PFFs were used to model immune crosstalk.

Paper 🌱 https://bit.ly/3HIG1nU
Product 🍃 https://bit.ly/2HJyYee
June 12, 2025 at 8:41 PM
stressmarq.bsky.social
Using StressMarq's #BetaSynuclein, #GammaSynuclein & #AmyloidBeta 1-42 PFFs, scientists developed a quiescent seed amplification assay (QSAA) to detect #AlphaSynuclein aggregates in #cerebrospinal fluid & #skin samples.

Read about it on the blog! https://bit.ly/43QvnTN
Optimizing Alpha Synuclein Seed Amplification Assays
Seed amplification assays detect abnormal forms of alpha synuclein. An improved quiescent SAA method streamlines this process and maintains tissue integrity.
bit.ly
June 12, 2025 at 4:46 PM
stressmarq.bsky.social
Product Citation: LRRK2 impairs the astrocytic uptake of α-synuclein via clusterin. A #Parkinson's disease model deployed StressMarq's #AlphaSynuclein PFFs to demonstrate that miR-22-5p may help restore function.

Paper 🔖 bit.ly/4k4WYXX
Mouse Alpha Synuclein PFFs 🐭 bit.ly/2HJyYee
June 11, 2025 at 6:50 PM