Rachel Mellon
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rachel-mell.bsky.social
Rachel Mellon
@rachel-mell.bsky.social
49 followers 93 following 0 posts
PhD student in the Barral Group @ ETHZürich 🇨🇭 interested in cell autonomous self non-self recognition and the ESCRT complex
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Reposted by Rachel Mellon
nature.com
Nature research paper: Progressive coevolution of the yeast centromere and kinetochore

go.nature.com/4rtOuhu
Progressive coevolution of the yeast centromere and kinetochore - Nature
Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new centromere variants are tolerated.
go.nature.com
December 3, 2025 at 2:14 PM
Reposted by Rachel Mellon
baym.lol
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Reposted by Rachel Mellon
martinpacesa.bsky.social
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Reposted by Rachel Mellon
jimhurley.bsky.social
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
The expanding repertoire of ESCRT functions in cell biology and disease - Nature
This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.
tinyurl.com
June 25, 2025 at 6:24 PM
Reposted by Rachel Mellon
rouxlab.bsky.social
The EMBO ESCRT meeting 2025 #EMBOescrt is open for registration: meetings.embo.org/event/25-escrt
Please share the info around you, and see you in Montreux!
ESCRT function, evolutionary diversity and mechanism of action
The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…
meetings.embo.org
February 5, 2025 at 7:37 AM
Reposted by Rachel Mellon
plosbiology.org
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi
Loss of D1 during embryogenesis triggers transposon expression in adult ovaries. Top: Ovaries from the indicated genotypes (D1 and aubergine mutants and heterozygotes, F1 and F2) were stained with Vasa (green) and DAPI (magenta). Bottom: RNA in situ hybridization against Copia (green) and total polyadenylated mRNA (blue) was performed in ovaries of the indicated genotypes that were also stained for DAPI (magenta). Yellow and black arrowheads indicate undifferentiated germ cells in the aubergine mutant germarium.
January 17, 2025 at 10:39 AM