Pat Eyers
@pseudoenzyme.bsky.social
Family, cell signalling, food, chillies, wildlife, dogs and rugby.
Reposted by Pat Eyers
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
www.nature.com
November 17, 2025 at 12:12 PM
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pat Eyers
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...
www.biorxiv.org
November 10, 2025 at 4:34 PM
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Very much worth a read. The Lords know what is needed to drive translational research. The Govt?
publications.parliament.uk/pa/ld5901/ld...
publications.parliament.uk/pa/ld5901/ld...
House of Lords - Bleeding to death: the science and technology growth emergency - Science and Technology Committee
publications.parliament.uk
November 10, 2025 at 11:54 AM
Very much worth a read. The Lords know what is needed to drive translational research. The Govt?
publications.parliament.uk/pa/ld5901/ld...
publications.parliament.uk/pa/ld5901/ld...
Reposted by Pat Eyers
Together with @pseudoenzyme.bsky.social I had a wonderful and very inspiring day at the Dyrk1a Syndrome Community Family Conference on Saturday. Wonderful families and wonderful support from volunteers at the Barnstondale Centre in the Wirral. Thank you for the warm welcome
July 28, 2025 at 8:32 AM
Together with @pseudoenzyme.bsky.social I had a wonderful and very inspiring day at the Dyrk1a Syndrome Community Family Conference on Saturday. Wonderful families and wonderful support from volunteers at the Barnstondale Centre in the Wirral. Thank you for the warm welcome
Reposted by Pat Eyers
We’re celebrating a global rise! 🎓
The University of Liverpool is now ranked 147th in the world in the QS World University Rankings 2026 — officially in the Top 150!
#TeamLivUni💙
Read more ⬇️
news.liverpool.ac.uk/2025/06/19/u...
The University of Liverpool is now ranked 147th in the world in the QS World University Rankings 2026 — officially in the Top 150!
#TeamLivUni💙
Read more ⬇️
news.liverpool.ac.uk/2025/06/19/u...
June 19, 2025 at 7:24 AM
We’re celebrating a global rise! 🎓
The University of Liverpool is now ranked 147th in the world in the QS World University Rankings 2026 — officially in the Top 150!
#TeamLivUni💙
Read more ⬇️
news.liverpool.ac.uk/2025/06/19/u...
The University of Liverpool is now ranked 147th in the world in the QS World University Rankings 2026 — officially in the Top 150!
#TeamLivUni💙
Read more ⬇️
news.liverpool.ac.uk/2025/06/19/u...
Reposted by Pat Eyers
NEWS I We will open a campus in Bengaluru, India, building on our strong existing collaborations in the region. In Delhi today, the Indian Minister of Education formally awarded our VC a Letter of Intent giving official permission for the campus 🇬🇧 🇮🇳
Read more: news.liverpool.ac.uk/2025/05/26/u...
Read more: news.liverpool.ac.uk/2025/05/26/u...
May 26, 2025 at 7:29 AM
NEWS I We will open a campus in Bengaluru, India, building on our strong existing collaborations in the region. In Delhi today, the Indian Minister of Education formally awarded our VC a Letter of Intent giving official permission for the campus 🇬🇧 🇮🇳
Read more: news.liverpool.ac.uk/2025/05/26/u...
Read more: news.liverpool.ac.uk/2025/05/26/u...
Reposted by Pat Eyers
Fantastic to be at the @royalsociety.org today celebrating progress and initiatives to support the technician community. @uk-itss.bsky.social @livunihls.bsky.social
May 21, 2025 at 10:06 AM
Fantastic to be at the @royalsociety.org today celebrating progress and initiatives to support the technician community. @uk-itss.bsky.social @livunihls.bsky.social
An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases | Science Signaling www.science.org/doi/10.1126/...
An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases
The bacterial serine-threonine kinome is a resource for functional studies and drug development.
www.science.org
May 7, 2025 at 6:12 PM
An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases | Science Signaling www.science.org/doi/10.1126/...
Reposted by Pat Eyers
What's the collective noun for @biochemsoc.bsky.social Morton Prize winners? We gathered together as many as we could get our hands on, including newest recipient Len.
From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.
From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.
May 1, 2025 at 3:23 PM
What's the collective noun for @biochemsoc.bsky.social Morton Prize winners? We gathered together as many as we could get our hands on, including newest recipient Len.
From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.
From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.
Reposted by Pat Eyers
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 2, 2025 at 10:31 AM
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pat Eyers
I'm am very excited - and little bit emotional - today as we start the two day Symposium to celebrate the achievements and retirement of my colleagues and chief PI3K gurus - Len Stephens and Phill Hawkins
May 1, 2025 at 10:30 AM
I'm am very excited - and little bit emotional - today as we start the two day Symposium to celebrate the achievements and retirement of my colleagues and chief PI3K gurus - Len Stephens and Phill Hawkins
A big day for @biochemsoc.bsky.social 2026 Morton Lecture awardee Dr Len Stepehns, introduced by @drsimoncook.bsky.social @babrahaminst.bsky.social
May 1, 2025 at 12:47 PM
A big day for @biochemsoc.bsky.social 2026 Morton Lecture awardee Dr Len Stepehns, introduced by @drsimoncook.bsky.social @babrahaminst.bsky.social
Reposted by Pat Eyers
Reposted by Pat Eyers
Final week for the early bird deadline for the Small G-protein meeting in Manchester. Talk slots available from submitted abstracts. #SGP25 @BiochemSoc @SmallGTPases Register here: bit.ly/SmallG25
Small G proteins in cellular signalling and disease 2025
bit.ly
April 22, 2025 at 4:58 PM
Final week for the early bird deadline for the Small G-protein meeting in Manchester. Talk slots available from submitted abstracts. #SGP25 @BiochemSoc @SmallGTPases Register here: bit.ly/SmallG25
Reposted by Pat Eyers
Don't miss out! The earlybird discount and abstract submission deadline for our upcoming small G protein conference is this Thursday 24 April! Submit your abstract for consideration and register now to save £50! #SGP25 🧪
www.eventsforce.net/biochemsoc/2...
www.eventsforce.net/biochemsoc/2...
April 22, 2025 at 9:39 AM
Don't miss out! The earlybird discount and abstract submission deadline for our upcoming small G protein conference is this Thursday 24 April! Submit your abstract for consideration and register now to save £50! #SGP25 🧪
www.eventsforce.net/biochemsoc/2...
www.eventsforce.net/biochemsoc/2...
Reposted by Pat Eyers
Really looking forward to this meeting!
🚨 Deadline extended! 🚨
Registration for the 2nd UK Proteostasis Network meeting in Dundee is open until 30 April!
🧬 Plenty of chances for selected talks from abstracts
📅 3–5 June 2025
📍 Dundee
🗓️ Program now live!
Sign up and view the programme here: dundee.ac.uk/events/joint...
Registration for the 2nd UK Proteostasis Network meeting in Dundee is open until 30 April!
🧬 Plenty of chances for selected talks from abstracts
📅 3–5 June 2025
📍 Dundee
🗓️ Program now live!
Sign up and view the programme here: dundee.ac.uk/events/joint...
Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK
Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!
dundee.ac.uk
April 22, 2025 at 11:39 AM
Really looking forward to this meeting!
A dapper Vinnie Tagliabracci picking up an @asbmb.bsky.social Early Career Scolar Award in between social engagements
April 15, 2025 at 7:30 PM
A dapper Vinnie Tagliabracci picking up an @asbmb.bsky.social Early Career Scolar Award in between social engagements
Reposted by Pat Eyers
Science fans of Liverpool - check out @liverpooluni.bsky.social Pint of Science nights and grab your tickets here pintofscience.co.uk/organisation... 🍻
@livunihls.bsky.social @livuniresearch.bsky.social @livuninews.bsky.social
@livunihls.bsky.social @livuniresearch.bsky.social @livuninews.bsky.social
April 14, 2025 at 1:22 PM
Science fans of Liverpool - check out @liverpooluni.bsky.social Pint of Science nights and grab your tickets here pintofscience.co.uk/organisation... 🍻
@livunihls.bsky.social @livuniresearch.bsky.social @livuninews.bsky.social
@livunihls.bsky.social @livuniresearch.bsky.social @livuninews.bsky.social
Reposted by Pat Eyers
Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
April 9, 2025 at 2:32 PM
Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
Pleased to be in Chicago. Part-science, part to support all our US colleagues @biochemsoc.bsky.social @asbmb.bsky.social
April 12, 2025 at 2:30 PM
Pleased to be in Chicago. Part-science, part to support all our US colleagues @biochemsoc.bsky.social @asbmb.bsky.social
Reposted by Pat Eyers
We are so proud of all our Biochemical Society 2026 Award winners. Visit our website to find out more about all of the deserving recipients 🧪 #BiochemAwards
ow.ly/bGbY50VwkYF
ow.ly/bGbY50VwkYF
April 8, 2025 at 3:48 PM
We are so proud of all our Biochemical Society 2026 Award winners. Visit our website to find out more about all of the deserving recipients 🧪 #BiochemAwards
ow.ly/bGbY50VwkYF
ow.ly/bGbY50VwkYF