PombeDoc
@pombedoc.bsky.social
Distinguished Professor, fission yeast geneticist. Replication stress and genome integrity. Photographer. 🏳️🌈
Reposted by PombeDoc
Reposted by PombeDoc
Some nice thoughts here. Of course Meselson and Stahl (my personal favorite) make an appearance, as well as Nirenberg and Matthaei and many others. If you need inspiration today to keep plugging along (which I do!), this is for you.
www.asimov.press/p/beautiful-...
www.asimov.press/p/beautiful-...
What Makes an Experiment Beautiful?
A beautiful experiment is not just a reflection of human ingenuity but also efficient science.
www.asimov.press
November 13, 2025 at 8:46 PM
Some nice thoughts here. Of course Meselson and Stahl (my personal favorite) make an appearance, as well as Nirenberg and Matthaei and many others. If you need inspiration today to keep plugging along (which I do!), this is for you.
www.asimov.press/p/beautiful-...
www.asimov.press/p/beautiful-...
Reposted by PombeDoc
CAN LLMs write about science? @science.org decided to find out, and they did it the curious, scientific way. They did an experiment.
Love this thoughtful convo. www.lastwordonnothing.com/2025/11/12/w...
Love this thoughtful convo. www.lastwordonnothing.com/2025/11/12/w...
The Last Word On Nothing | Why AAAS won’t be using AI to write press releases anytime soon
www.lastwordonnothing.com
November 13, 2025 at 4:19 PM
CAN LLMs write about science? @science.org decided to find out, and they did it the curious, scientific way. They did an experiment.
Love this thoughtful convo. www.lastwordonnothing.com/2025/11/12/w...
Love this thoughtful convo. www.lastwordonnothing.com/2025/11/12/w...
Reposted by PombeDoc
Just a fundamental misunderstanding of how the scientific method works: It's not that someone *disagrees* was theory or finding and then argues with it, it's that you've got data that doesn't align and you go from there. Science isn't really about agreement or disagreement in an emotional sense.
JD Vance: "Science as practiced in its best form is that if you disagree with it, then you ought to criticize it and you ought to argue against it."
November 12, 2025 at 6:50 PM
Just a fundamental misunderstanding of how the scientific method works: It's not that someone *disagrees* was theory or finding and then argues with it, it's that you've got data that doesn't align and you go from there. Science isn't really about agreement or disagreement in an emotional sense.
Reposted by PombeDoc
I never imagined I’d need to turn to our judicial system to explain the importance of America’s scientific research, but here we are. Thanks to @BrennanCenter.org for highlighting my amicus brief 1/2
Harms of the Federal Funding Freeze on Science
A venture capitalist and former White House science adviser discusses the impact of the Trump administration’s attempted funding freeze on the future of research and innovation.
www.brennancenter.org
November 11, 2025 at 8:45 PM
I never imagined I’d need to turn to our judicial system to explain the importance of America’s scientific research, but here we are. Thanks to @BrennanCenter.org for highlighting my amicus brief 1/2
If any Senator caves, never ever vote for any of them again. Any of them.
November 9, 2025 at 10:12 PM
If any Senator caves, never ever vote for any of them again. Any of them.
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The premise of generative AI is that so much has been written, painted, drawn, and composed that we no longer need to make anything new and can be happy with regurgitations of everything from here on out.
November 5, 2025 at 5:48 PM
The premise of generative AI is that so much has been written, painted, drawn, and composed that we no longer need to make anything new and can be happy with regurgitations of everything from here on out.
Reposted by PombeDoc
New York Times editorial board has compiled "a list of 12 markers of democratic erosion." www.nytimes.com/interactive/...
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
October 31, 2025 at 2:36 PM
New York Times editorial board has compiled "a list of 12 markers of democratic erosion." www.nytimes.com/interactive/...
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
I just discovered i have a Wikipedia page.
I didnt create it and it’s not entirely accurate.
Now what.
I didnt create it and it’s not entirely accurate.
Now what.
October 30, 2025 at 4:12 PM
I just discovered i have a Wikipedia page.
I didnt create it and it’s not entirely accurate.
Now what.
I didnt create it and it’s not entirely accurate.
Now what.
I want @dieworkwear.bsky.social to comment on #dapperguy
October 24, 2025 at 2:08 AM
I want @dieworkwear.bsky.social to comment on #dapperguy
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@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Scaling back DEI programmes and the loss of scientific talent
Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...
www.nature.com
October 23, 2025 at 4:36 PM
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Reposted by PombeDoc
Breaking: The Supreme Court is now officially considering taking up a case overturning same-sex marriage.
This is the first time in history the court has considered rolling back this right.
This is the first time in history the court has considered rolling back this right.
October 23, 2025 at 3:08 PM
Breaking: The Supreme Court is now officially considering taking up a case overturning same-sex marriage.
This is the first time in history the court has considered rolling back this right.
This is the first time in history the court has considered rolling back this right.
Reposted by PombeDoc
My contribution today
October 18, 2025 at 5:38 PM
My contribution today
Reposted by PombeDoc
you fucked around and now the Episcopalians are doing memes. are you happy now. are you
October 15, 2025 at 4:10 PM
you fucked around and now the Episcopalians are doing memes. are you happy now. are you
as well as I5 freeway, the railway will also be shut through Camp Pendleton tomorrow to avoid the live ammo being hurled onshore.
Just severing the ENTIRE transport connection between the 2nd and 8th largest US metros
Just severing the ENTIRE transport connection between the 2nd and 8th largest US metros
October 16, 2025 at 9:54 PM
as well as I5 freeway, the railway will also be shut through Camp Pendleton tomorrow to avoid the live ammo being hurled onshore.
Just severing the ENTIRE transport connection between the 2nd and 8th largest US metros
Just severing the ENTIRE transport connection between the 2nd and 8th largest US metros
FIGHT ON!!!!
BREAKING: USC HAS JOIN THE RESISTANCE!
That’s four (MIT, Brown, Penn, USC) of the nine schools Trump targeted.
Stay tuned! 🍿
#DefendHigherEd
#StandUpFightBack
That’s four (MIT, Brown, Penn, USC) of the nine schools Trump targeted.
Stay tuned! 🍿
#DefendHigherEd
#StandUpFightBack
USC rejects Trump education compact aimed at shifting the university to the right
USC interim President Beong-Soo Kim said in a statement that he had sent a letter to the U.S. Department of Education turning down the Trump offer.
www.latimes.com
October 16, 2025 at 9:27 PM
FIGHT ON!!!!
Are you kidding me???
LA Times now confirming our earlier reporting: www.latimes.com/california/s...
October 16, 2025 at 3:07 AM
Are you kidding me???
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Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
Nature - A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable...
rdcu.be
October 15, 2025 at 9:06 PM
Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
Reposted by PombeDoc
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
www.biorxiv.org
October 12, 2025 at 9:16 PM
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Proud to be an MIT alum today.
October 10, 2025 at 6:26 PM
Proud to be an MIT alum today.
Reposted by PombeDoc
This is what courage in the face of authoritarianism looks like. No university should take Trump's bribe & surrender their integrity — bending the knee to a bully only feeds the beast & puts ALL our rights at risk.
Others should follows MIT’s example ASAP.
Others should follows MIT’s example ASAP.
MIT rejects Trump administration deal for priority federal funding
MIT is one of the nine schools that were asked to agree to adopt conservative priorities and policies in exchange for funding perks.
www.washingtonpost.com
October 10, 2025 at 5:22 PM
This is what courage in the face of authoritarianism looks like. No university should take Trump's bribe & surrender their integrity — bending the knee to a bully only feeds the beast & puts ALL our rights at risk.
Others should follows MIT’s example ASAP.
Others should follows MIT’s example ASAP.
Reposted by PombeDoc
Craig Taborn is a genius, and a Genius: www.nytimes.com/2025/10/08/a...
MacArthur Foundation Announces 2025 ‘Genius Grant’ Winners
www.nytimes.com
October 8, 2025 at 4:42 PM
Craig Taborn is a genius, and a Genius: www.nytimes.com/2025/10/08/a...
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when you try and get your PhD advisor to review your manuscript 😂
October 7, 2025 at 5:06 PM
when you try and get your PhD advisor to review your manuscript 😂
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This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
scim.ag
October 6, 2025 at 1:45 PM
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi