Pierre Mangeol
@pierremangeol.bsky.social
Interdisciplinary research in Biophysics / Microscopy / Cell biology / Bioinformatics - lecturer in Biostatistics
IBDM - Aix-Marseille University
IBDM - Aix-Marseille University
Reposted by Pierre Mangeol
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
Biophysicists are realizing that there is an undervalued element at play in early development: Aside from genes, mechanical forces also steer the growth of embryos. @annademming.bsky.social reports: www.quantamagazine.org/genes-have-h...
Genes Have Harnessed Physics to Help Grow Living Things | Quanta Magazine
The same pulling force that causes “tears” in a glass of wine also shapes embryos. It’s another example of how genes exploit mechanical forces for growth and development.
www.quantamagazine.org
October 11, 2025 at 7:04 AM
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
Reposted by Pierre Mangeol
Congratulations @philipschoene.bsky.social on defending his Master’s thesis on the supremacy of mechanics in Hydra regeneration from aggregates of dissociated cells. Expertly guided by @anaisbailles.bsky.social. #experiment and #theory #LoPaTs @mpi-cbg.de @poldresden.bsky.social #stuffthatmatters
September 23, 2025 at 10:03 AM
Congratulations @philipschoene.bsky.social on defending his Master’s thesis on the supremacy of mechanics in Hydra regeneration from aggregates of dissociated cells. Expertly guided by @anaisbailles.bsky.social. #experiment and #theory #LoPaTs @mpi-cbg.de @poldresden.bsky.social #stuffthatmatters
Reposted by Pierre Mangeol
Reposted by Pierre Mangeol
✨ Post-doc opportunity in axon biology, funded by #ATIP-Avenir!
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
Portail Emploi CNRS - Offre d'emploi - Post-doctoral researcher in axon biology (M/F)
emploi.cnrs.fr
September 11, 2025 at 12:24 PM
✨ Post-doc opportunity in axon biology, funded by #ATIP-Avenir!
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
Reposted by Pierre Mangeol
Hydra are ~basically~ immortal.
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Hydra are a cosmos in a cuvette
Anaïs Bailles on astrophysics and immortal animals
www.reviewertoo.com
September 11, 2025 at 5:49 PM
Hydra are ~basically~ immortal.
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Reposted by Pierre Mangeol
Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.
Hydra are ~basically~ immortal.
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Shred 50 of the lil guys to bits and pack their cells in a blob, and that blob will grow into a new Hydra... albeit with a few extra heads!
This week's post is a Q&A @anaisbailles.bsky.social @mpi-cbg.de about the physics of how Hydra coax order from chaos.🧪⚛️
Hydra are a cosmos in a cuvette
Anaïs Bailles on astrophysics and immortal animals
www.reviewertoo.com
September 12, 2025 at 1:56 PM
Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.
Reposted by Pierre Mangeol
[PUBLI] Observing muscle growth brick by brick
A research project at the @ibdm.bsky.social, led by Clément Rodier, has recently challenged long-standing scientific hypotheses about how muscles elongate during development, thanks to advanced #microscopy.
🔗 Our article in comments
A research project at the @ibdm.bsky.social, led by Clément Rodier, has recently challenged long-standing scientific hypotheses about how muscles elongate during development, thanks to advanced #microscopy.
🔗 Our article in comments
September 4, 2025 at 10:18 AM
[PUBLI] Observing muscle growth brick by brick
A research project at the @ibdm.bsky.social, led by Clément Rodier, has recently challenged long-standing scientific hypotheses about how muscles elongate during development, thanks to advanced #microscopy.
🔗 Our article in comments
A research project at the @ibdm.bsky.social, led by Clément Rodier, has recently challenged long-standing scientific hypotheses about how muscles elongate during development, thanks to advanced #microscopy.
🔗 Our article in comments
Reposted by Pierre Mangeol
Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...
August 29, 2025 at 1:57 PM
Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...
Reposted by Pierre Mangeol
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 27, 2025 at 10:50 AM
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pierre Mangeol
Our beautiful Hydra made the cover!!! 😍😍😍
An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de
Actin fibers in blue, nuclei in orange.
An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de
Actin fibers in blue, nuclei in orange.
August 13, 2025 at 8:51 AM
Our beautiful Hydra made the cover!!! 😍😍😍
An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de
Actin fibers in blue, nuclei in orange.
An experiment performed by Pavel Mejstrik with a HCR protocol by @giuliaserafini.bsky.social, @paveltomancak.bsky.social lab @mpi-cbg.de
Actin fibers in blue, nuclei in orange.
Reposted by Pierre Mangeol
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
August 6, 2025 at 1:09 PM
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
Reposted by Pierre Mangeol
Stretching the immortal Hydra. Publication by @paveltomancak.bsky.social group with Carl Modes @mpi-cbg.de & @zechnerlab.bsky.social shows how cells can create a new organism from scratch by coordinating their mechanical properties. @anaisbailles.bsky.social @pnas.org www.mpi-cbg.de/news-outreac...
Stretching the immortal Hydra
Dresden researchers show how cells can create a new organism from scratch by coordinating their mechanical properties.
www.mpi-cbg.de
August 5, 2025 at 12:45 PM
Stretching the immortal Hydra. Publication by @paveltomancak.bsky.social group with Carl Modes @mpi-cbg.de & @zechnerlab.bsky.social shows how cells can create a new organism from scratch by coordinating their mechanical properties. @anaisbailles.bsky.social @pnas.org www.mpi-cbg.de/news-outreac...
Reposted by Pierre Mangeol
Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!
Explant elongation initiates in the epithelium
A Research Highlight showcasing new work from @katiabarrett.bsky.social, Shalabh Anand, Virginie Thome, Laurent Kodjabachian, @merkellab.bsky.social, @pflenne.bsky.social
journals.biologists.com/dev/article/...
A Research Highlight showcasing new work from @katiabarrett.bsky.social, Shalabh Anand, Virginie Thome, Laurent Kodjabachian, @merkellab.bsky.social, @pflenne.bsky.social
journals.biologists.com/dev/article/...
July 31, 2025 at 10:39 AM
Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!
Reposted by Pierre Mangeol
🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT
July 31, 2025 at 8:56 AM
🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT
Reposted by Pierre Mangeol
Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
July 21, 2025 at 12:52 PM
Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
Reposted by Pierre Mangeol
Congratulations @alicegros.bsky.social @jules-vanaret.bsky.social & @dunsingvalentin.bsky.social for this huge team effort! Gastruloids morphogenesis is so fascinating and now we can explore and travel through them in 3D & at cell resolution day and night 🤩
So excited to share my 1st paper !!🌞
Co-authored with @jules-vanaret.bsky.social @dunsingvalentin.bsky.social, we developped an integrated pipeline for imaging, segmenting and analysing cell-scale patterns in gene expression + tissue properties in complex 3D tissues
elifesciences.org/reviewed-pre...
Co-authored with @jules-vanaret.bsky.social @dunsingvalentin.bsky.social, we developped an integrated pipeline for imaging, segmenting and analysing cell-scale patterns in gene expression + tissue properties in complex 3D tissues
elifesciences.org/reviewed-pre...
A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales
elifesciences.org
July 16, 2025 at 7:21 AM
Congratulations @alicegros.bsky.social @jules-vanaret.bsky.social & @dunsingvalentin.bsky.social for this huge team effort! Gastruloids morphogenesis is so fascinating and now we can explore and travel through them in 3D & at cell resolution day and night 🤩
Reposted by Pierre Mangeol
🥇Sham Tlili has been awarded the CNRS 2025 Bronze Medal! She studies how physical forces shape living tissues by using mouse stem cell models known as gastruloids. A unique blend of physics & biology.
🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...
🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...
Sham Tlili, winner of the CNRS 2025 bronze medal - IBDM | Institut de Biologie du Développement de Marseille
A distinction that rewards a promising and already fruitful scientific career.
www.ibdm.univ-amu.fr
June 27, 2025 at 9:00 AM
🥇Sham Tlili has been awarded the CNRS 2025 Bronze Medal! She studies how physical forces shape living tissues by using mouse stem cell models known as gastruloids. A unique blend of physics & biology.
🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...
🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...
Reposted by Pierre Mangeol
#LoPaT @anaisbailles.bsky.social bringing up the wonders of #Hydra, #physics, disorder to order transition and tissue mechanics to #TCTeAC
June 11, 2025 at 3:00 PM
#LoPaT @anaisbailles.bsky.social bringing up the wonders of #Hydra, #physics, disorder to order transition and tissue mechanics to #TCTeAC
Beautiful work!
Hooray. Yesterday, my very first #Hydra paper was accepted! An exciting time for a career #Drosophilist. Big congratulations to @anaisbailles.bsky.social, who set up the Hydra system from scratch. Thanks Carl Modes for the liquid crystal theory. @mpi-cbg.de Preprint:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates
During development, groups of cells generate shape by coordinating their mechanical properties through an interplay of self-organization and pre-patterning. Hydra displays a striking planar pattern of...
www.biorxiv.org
June 4, 2025 at 1:14 PM
Beautiful work!
Reposted by Pierre Mangeol
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
May 10, 2025 at 11:15 AM
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Pierre Mangeol
Super proud of superstar postdocs @nerlielisa.bsky.social and @liujinghui.bsky.social for our lab's most recent preprint! We uncover how wound-induced electrical currents are generated and transmitted in tissues, triggering proliferation, essential for organ #regeneration #bioelectricity #QBio 👇
How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation.
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
April 9, 2025 at 2:19 PM
Super proud of superstar postdocs @nerlielisa.bsky.social and @liujinghui.bsky.social for our lab's most recent preprint! We uncover how wound-induced electrical currents are generated and transmitted in tissues, triggering proliferation, essential for organ #regeneration #bioelectricity #QBio 👇
Reposted by Pierre Mangeol
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
Author summary MicroRNAs (miRNAs) are small RNAs that silence messenger RNAs (mRNAs) by binding to partially complementary sequences. They play a crucial role in cell type specification during develop...
journals.plos.org
April 30, 2025 at 4:50 PM
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
Reposted by Pierre Mangeol
Our new call for VIB.AI group leaders is online! Junior and senior positions available to develop innovative ML methods in biology. With professorship at CS or Medical Faculty. Deadline 14th June. DM for more info.
We are looking for additional Group Leaders to join the growing computational biology community at VIB.
If you are excited about combining AI and machine learning with fundamental biology, we would love to hear from you!
https://vib.ai/en/opportunities#/job-description/110906
If you are excited about combining AI and machine learning with fundamental biology, we would love to hear from you!
https://vib.ai/en/opportunities#/job-description/110906
April 26, 2025 at 11:00 AM
Our new call for VIB.AI group leaders is online! Junior and senior positions available to develop innovative ML methods in biology. With professorship at CS or Medical Faculty. Deadline 14th June. DM for more info.
Reposted by Pierre Mangeol
The @embo.org practical course on #lightsheet #microscopy is back!
Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more
Apply now!
Repost 🙏
meetings.embo.org/event/25-lsm
Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more
Apply now!
Repost 🙏
meetings.embo.org/event/25-lsm
Light sheet microscopy
Light sheet microscopy is a technology that enables near-isotropic imaging of large biological specimens over time. It opens new avenues to study biological processes with unprecedented imaging speed…
meetings.embo.org
April 15, 2025 at 8:33 AM
The @embo.org practical course on #lightsheet #microscopy is back!
Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more
Apply now!
Repost 🙏
meetings.embo.org/event/25-lsm
Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more
Apply now!
Repost 🙏
meetings.embo.org/event/25-lsm
Reposted by Pierre Mangeol
⏳ Don’t miss out ⏳
🕊️ Early bird registration for Shaping Life 3 is open until April 1, 2025!
🌊 Join us in Cassis, France, June 3-6 for a top-tier developmental biology conference by the sea.
Secure your spot now 👇
🕊️ Early bird registration for Shaping Life 3 is open until April 1, 2025!
🌊 Join us in Cassis, France, June 3-6 for a top-tier developmental biology conference by the sea.
Secure your spot now 👇
REGISTRATION - Shaping Life 3
REGISTRATION To become a SFBD member click HERE Registration fee includes:– Access to the conferences and posters sessions– Catering during 4 days: welcome cocktail on June 3, 2025, 6 coffee breaks and 2 lunches – Abstract submission – Outside activity on June 4, 2025– Abstracts book (to download online) Registration fee DOES NOT include:– Travel from… Continue reading REGISTRATION
www.atoutcom.com
March 26, 2025 at 9:03 AM
⏳ Don’t miss out ⏳
🕊️ Early bird registration for Shaping Life 3 is open until April 1, 2025!
🌊 Join us in Cassis, France, June 3-6 for a top-tier developmental biology conference by the sea.
Secure your spot now 👇
🕊️ Early bird registration for Shaping Life 3 is open until April 1, 2025!
🌊 Join us in Cassis, France, June 3-6 for a top-tier developmental biology conference by the sea.
Secure your spot now 👇