Piere Rodriguez-Aliaga
@pierebiophysics.bsky.social
@Stanford Postdoc • @UCBerkeley PhD Biophysics • @hdfcures fellow • Protein misfolding linked to neuro diseases • Single-molecule tools • Space/Pisco enthusiast
Pinned
Rare and mysterious brain malformations in children may be linked to protein misfolding and tied to developmental disorders that include seizures and intellectual disability, Stanford Medicine-led research has found.
Rare, mysterious brain malformations in children linked to protein misfolding, study finds
Mutations in a complex that helps proteins fold correctly are tied to developmental disorders that include seizures and intellectual disability, Stanford Medicine-led research has found.
med.stanford.edu
Did not get a chance to share in this platform our recent study from the Frydman Lab and colleagues in Aachen and WashU published in @science.org where we establish that mutations in the TRiC chaperonin are directly linked with the onset of a set of new brain disorders we have called "TRiCopathies".
Did not get a chance to share in this platform our recent study from the Frydman Lab and colleagues in Aachen and WashU published in @science.org where we establish that mutations in the TRiC chaperonin are directly linked with the onset of a set of new brain disorders we have called "TRiCopathies".
Rare and mysterious brain malformations in children may be linked to protein misfolding and tied to developmental disorders that include seizures and intellectual disability, Stanford Medicine-led research has found.
Rare, mysterious brain malformations in children linked to protein misfolding, study finds
Mutations in a complex that helps proteins fold correctly are tied to developmental disorders that include seizures and intellectual disability, Stanford Medicine-led research has found.
med.stanford.edu
May 22, 2025 at 6:59 AM
Did not get a chance to share in this platform our recent study from the Frydman Lab and colleagues in Aachen and WashU published in @science.org where we establish that mutations in the TRiC chaperonin are directly linked with the onset of a set of new brain disorders we have called "TRiCopathies".
Reposted by Piere Rodriguez-Aliaga
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 21, 2025 at 7:21 PM
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
It was a pleasure to participate in the "Protein folding & Chaperones" platform session this morning in #bps2025 sharing our story from the
@FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding
@FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding
February 17, 2025 at 10:12 PM
It was a pleasure to participate in the "Protein folding & Chaperones" platform session this morning in #bps2025 sharing our story from the
@FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding
@FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding
Reposted by Piere Rodriguez-Aliaga
Happy to share the final program of the 2025 Intrinsically Disordered Proteins Subgroup Symposium at the Biophysical Society Meeting to be held in Los Angeles on February 15. Looking forward to seeing you all in less than a week @biophysicalsoc.bsky.social.
February 9, 2025 at 12:57 PM
Happy to share the final program of the 2025 Intrinsically Disordered Proteins Subgroup Symposium at the Biophysical Society Meeting to be held in Los Angeles on February 15. Looking forward to seeing you all in less than a week @biophysicalsoc.bsky.social.
After 3 years, in my way to #bps2025 in Los Angeles, whose heavy traffic reminds of Lima. Happy to present:
*Feb 15: Flash talk IDP symposium - Huntingtin conformation
*Feb 17: Platform talk protein folding - TRiC mutations and brain disorders
*Posters: B135 Huntingtina (Sunday), B56 TRiC (Tuesday)
*Feb 15: Flash talk IDP symposium - Huntingtin conformation
*Feb 17: Platform talk protein folding - TRiC mutations and brain disorders
*Posters: B135 Huntingtina (Sunday), B56 TRiC (Tuesday)
February 15, 2025 at 3:54 AM
After 3 years, in my way to #bps2025 in Los Angeles, whose heavy traffic reminds of Lima. Happy to present:
*Feb 15: Flash talk IDP symposium - Huntingtin conformation
*Feb 17: Platform talk protein folding - TRiC mutations and brain disorders
*Posters: B135 Huntingtina (Sunday), B56 TRiC (Tuesday)
*Feb 15: Flash talk IDP symposium - Huntingtin conformation
*Feb 17: Platform talk protein folding - TRiC mutations and brain disorders
*Posters: B135 Huntingtina (Sunday), B56 TRiC (Tuesday)
Reposted by Piere Rodriguez-Aliaga
The TRiC chaperonin visualised in cells. In the open state, it's bound by PDCD5. And also... TRiC are enriched at the exit tunnel side of the ribosome! Exceptional study by Martin Beck @mpib.bsky.social and Judith Frydman labs out in Nature.
December 11, 2024 at 6:46 PM
The TRiC chaperonin visualised in cells. In the open state, it's bound by PDCD5. And also... TRiC are enriched at the exit tunnel side of the ribosome! Exceptional study by Martin Beck @mpib.bsky.social and Judith Frydman labs out in Nature.
Reposted by Piere Rodriguez-Aliaga
#TeamTomo is at it again. Nice look at the conformational cycle of protein folding machinery inside native human cells by the teams of Frydman & Beck 🧪🔬🧶🧬
@nature, researchers report on their cryo-ET analysis of human TRiC/CCT -- the ATP-driven chaperonin the dysfunction of which is linked to disease. The work provides mechanistic insights into the functioning of this protein-folding machine within cells.
shorturl.at/H69Ye
shorturl.at/H69Ye
In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor - Nature
TRiC functions at near full occupancy to fold newly synthesized proteins inside cells.
shorturl.at
December 11, 2024 at 6:57 PM
#TeamTomo is at it again. Nice look at the conformational cycle of protein folding machinery inside native human cells by the teams of Frydman & Beck 🧪🔬🧶🧬