Peter Laurin
@peterlaurin.bsky.social
PhD Student at UCLA studying the genetics and evolution of bacteria in the gut microbiome.
peterlaurin.github.io
peterlaurin.github.io
Reposted by Peter Laurin
My best Holiday Giving Guide yet, highlighting three superb nonprofits saving and transforming lives abroad and at home. And because of matches from @bloombergdotorg.bsky.social & others, each $1 from you means $4 reaches the nonprofits. Join in! Spread the word. www.nytimes.com/2025/11/22/o...
Opinion | Gifts That Save Lives
www.nytimes.com
November 22, 2025 at 1:25 PM
My best Holiday Giving Guide yet, highlighting three superb nonprofits saving and transforming lives abroad and at home. And because of matches from @bloombergdotorg.bsky.social & others, each $1 from you means $4 reaches the nonprofits. Join in! Spread the word. www.nytimes.com/2025/11/22/o...
Reposted by Peter Laurin
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Peter Laurin
Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...
High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation
The extent to which adaptation can be predicted, particularly for traits with complex genetic bases, is unknown. Here, we leveraged a model complex trait, model species, and high-powered longitudinal ...
doi.org
November 18, 2025 at 12:15 AM
Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...
Reposted by Peter Laurin
Super excited about this work! In brief, we can predict evolution of a trait if we use complete genetic mapping but individual loci often do idiosyncratic things and go in the opposite direction from the one based on the evolution of the trait itself. Very curious to know what you think! 1/2
Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...
High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation
The extent to which adaptation can be predicted, particularly for traits with complex genetic bases, is unknown. Here, we leveraged a model complex trait, model species, and high-powered longitudinal ...
doi.org
November 18, 2025 at 12:27 AM
Super excited about this work! In brief, we can predict evolution of a trait if we use complete genetic mapping but individual loci often do idiosyncratic things and go in the opposite direction from the one based on the evolution of the trait itself. Very curious to know what you think! 1/2
Reposted by Peter Laurin
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
Insertion of an invading retrovirus regulates a novel color trait in swordtail fish
For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...
shorturl.at
November 12, 2025 at 8:34 PM
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
Reposted by Peter Laurin
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
November 6, 2025 at 9:51 PM
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
Reposted by Peter Laurin
Community coalescence reveals strong selection and coexistence within species in complex microbial communities https://www.biorxiv.org/content/10.1101/2025.11.06.687011v1
November 8, 2025 at 1:32 AM
Community coalescence reveals strong selection and coexistence within species in complex microbial communities https://www.biorxiv.org/content/10.1101/2025.11.06.687011v1
Reposted by Peter Laurin
Reposted by Peter Laurin
🧬 🦠 🏙️
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
November 5, 2025 at 2:04 AM
🧬 🦠 🏙️
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host?
Excited to share our new paper: www.biorxiv.org/content/10.1...
Reposted by Peter Laurin
Is the human microbiome a source for hospital-associated infections (HAI) and are any genetic changes associated with HAI? In our new preprint, we longitudinally reconstruct the evolutionary processes within the human microbiome leading up to HAI: doi.org/10.1101/2025...
Colonization, translocation, and evolution of opportunistic pathogens during hospital-associated infections
Many commensal bacteria that peacefully reside in the human microbiome are also able to cause acute opportunistic infections. Emerging evidence suggests that within-host evolution contributes to infec...
doi.org
October 27, 2025 at 9:25 AM
Is the human microbiome a source for hospital-associated infections (HAI) and are any genetic changes associated with HAI? In our new preprint, we longitudinally reconstruct the evolutionary processes within the human microbiome leading up to HAI: doi.org/10.1101/2025...
Reposted by Peter Laurin
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
October 24, 2025 at 1:51 AM
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Reposted by Peter Laurin
We couldn't not rate this classic early DAG by our beloved collective granddagy, Sewall Wright.
14/10. Ten for the DAG, plus one for each cute guinea-pig node.
From Wright (1920) "The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs"
14/10. Ten for the DAG, plus one for each cute guinea-pig node.
From Wright (1920) "The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs"
October 17, 2025 at 1:36 PM
We couldn't not rate this classic early DAG by our beloved collective granddagy, Sewall Wright.
14/10. Ten for the DAG, plus one for each cute guinea-pig node.
From Wright (1920) "The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs"
14/10. Ten for the DAG, plus one for each cute guinea-pig node.
From Wright (1920) "The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs"
Reposted by Peter Laurin
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
Reposted by Peter Laurin
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
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October 12, 2025 at 2:10 PM
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
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🧵
Reposted by Peter Laurin
Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT
October 14, 2025 at 12:58 PM
Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT
Reposted by Peter Laurin
The first Aguillon Lab paper is officially out in early view at Evolution!! Led by postdoc @devonderaad.bsky.social, we’ve explored the hybrid zone between black-headed and rose-breasted grosbeaks in the Great Plains. #ornithology #hybridization #speciation #evolution doi.org/10.1093/evol...
September 12, 2025 at 3:49 PM
The first Aguillon Lab paper is officially out in early view at Evolution!! Led by postdoc @devonderaad.bsky.social, we’ve explored the hybrid zone between black-headed and rose-breasted grosbeaks in the Great Plains. #ornithology #hybridization #speciation #evolution doi.org/10.1093/evol...
Reposted by Peter Laurin
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?
Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...
Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics
Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...
www.microbiologyresearch.org
September 1, 2025 at 5:49 PM
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?
Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...
Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...
Reposted by Peter Laurin
the crisis in which the University of Chicago is now engulfed -- one entirely of its own making, and which has led to the (hopefully temporary) suspension of admissions into numerous PhD programs in the humanities -- represents I think a seismic event in the history of American higher education
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August 23, 2025 at 3:51 PM
the crisis in which the University of Chicago is now engulfed -- one entirely of its own making, and which has led to the (hopefully temporary) suspension of admissions into numerous PhD programs in the humanities -- represents I think a seismic event in the history of American higher education
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Reposted by Peter Laurin
New paper out @molbioevol.bsky.social on antimutator Ecoli, mutational spectra and the distribution of fitness effects of antibiotic resistance with @knightjar.bsky.social @rokkrasovec.bsky.social and others @mermanchester.bsky.social doi.org/pzfm
Read🧵for highlights and fun stats (1/13)
Read🧵for highlights and fun stats (1/13)
Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ
Abstract. The rate of spontaneous mutation is a key factor in determining the capacity of a population to adapt to a novel environment, for example, a bact
doi.org
August 18, 2025 at 3:40 PM
New paper out @molbioevol.bsky.social on antimutator Ecoli, mutational spectra and the distribution of fitness effects of antibiotic resistance with @knightjar.bsky.social @rokkrasovec.bsky.social and others @mermanchester.bsky.social doi.org/pzfm
Read🧵for highlights and fun stats (1/13)
Read🧵for highlights and fun stats (1/13)
Reposted by Peter Laurin
Excited to share a new preprint w/ the Sonnenberg lab, led by Matt Carter, @zzzhiru.bsky.social & @mattolm.bsky.social. We analyzed the microbiomes of two non-industrialized populations from opposite sides of the globe to try to reconstruct the recent evolutionary history of our gut microbiota.
Prehistoric Global Migration of Vanishing Gut Microbes With Humans
The gut microbiome is crucial for health and greatly affected by lifestyle. Many microbes common in non-industrialized populations are disappearing or extinct in industrialized populations. Understand...
www.biorxiv.org
August 16, 2025 at 6:25 PM
Excited to share a new preprint w/ the Sonnenberg lab, led by Matt Carter, @zzzhiru.bsky.social & @mattolm.bsky.social. We analyzed the microbiomes of two non-industrialized populations from opposite sides of the globe to try to reconstruct the recent evolutionary history of our gut microbiota.
Reposted by Peter Laurin
I'm excited to announce our new biorxiv preprint, wherein we investigate the evolution of the weirdest genetic locus I've ever seen! Behold the tgr genes of the social amoeba, which mediate self/non-self discrimination during facultative multicellularity 🐅 🧵 1/
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium
Cells require highly polymorphic receptors to perform accurate self/non-self recognition. In the amoeba Dicytostelium discoideum, polymorphic TgrB1 & TgrC1 proteins are used to bind sister cells and e...
www.biorxiv.org
August 5, 2025 at 12:56 AM
I'm excited to announce our new biorxiv preprint, wherein we investigate the evolution of the weirdest genetic locus I've ever seen! Behold the tgr genes of the social amoeba, which mediate self/non-self discrimination during facultative multicellularity 🐅 🧵 1/
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Peter Laurin
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
August 2, 2025 at 2:15 AM
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
Reposted by Peter Laurin
Breaking: NSF is suspending roughly 300 grants with UCLA, following a DOJ finding on Tuesday that the university violated Title VI by "creating a hostile educational environment for Jewish and Israeli students."
July 31, 2025 at 5:53 PM
Breaking: NSF is suspending roughly 300 grants with UCLA, following a DOJ finding on Tuesday that the university violated Title VI by "creating a hostile educational environment for Jewish and Israeli students."
Reposted by Peter Laurin
Network, we are looking for PhD students and Postdocs on evolutionary and ecological genomics in 2025/2026
Join our diverse and welcoming lab at UC Berkeley & HHMINEWS!
Check job ads-> www.moilab.science/team/join-us
Join our diverse and welcoming lab at UC Berkeley & HHMINEWS!
Check job ads-> www.moilab.science/team/join-us
M O I L A B - Join us!
Join us!
Our lab is based at the University of California, Berkeley, embedded in the vibrant and multicultural San Francisco Bay Area, surrounded by astonishing nature!
www.moilab.science
July 22, 2025 at 10:32 PM
Network, we are looking for PhD students and Postdocs on evolutionary and ecological genomics in 2025/2026
Join our diverse and welcoming lab at UC Berkeley & HHMINEWS!
Check job ads-> www.moilab.science/team/join-us
Join our diverse and welcoming lab at UC Berkeley & HHMINEWS!
Check job ads-> www.moilab.science/team/join-us
Reposted by Peter Laurin
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!
July 22, 2025 at 7:34 PM
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.
See thread for more information and reach out!
See thread for more information and reach out!