Nature - Photocatalytic oxygen-atom transmutation of oxetanes

Research explained how body protects itself from the immune system, offering new ways to treat autoimmune disease

Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

Protein-ligand binding, selectivity, and affinity dictate the effects of drugs and endogenous molecules in cells. Currently, potential protein-ligand interactions are identified by qualitative interpretation of proteomic, transcriptomic, or genomic data, then binding affinities of hits are measured using purified proteins or engineered reporter systems to validate and quantify the strength of individual interactions. Few methods enable simultaneous target identification and biophysical affinity measurement, and these either apply to specific enzyme classes or proteins with ligand dependent shifts in stability. Here we describe a general platform, termed Affinity Map, which leverages competitive binding analysis, high fidelity photocatalytic labeling, and high throughput proteomics for global quantitative binding affinity profiling. We show that this method is applicable to major classes of ligands, including small molecules, linear peptides, cyclic peptides, and proteins, and can measure affinities between unmodified ligands and proteins in cell lysates, organ extracts, and live cell surfaces. ### Competing Interest Statement J.B.G., N.Y., C.D.W., and S.P. are inventors on a provisional patent application (63/720,063) filed by Cornell University related to this work. National Institute of General Medical Sciences, https://ror.org/04q48ey07, R35GM147449, T32GM136640-TAN, R35GM147449-02S1

Herein we describe a comprehensive study of ligand effects on optoelectronic properties of a series of Ir(III) catalysts which undergo formally spin-forbidden excitation using low-energy light. We dem...

“Cézanne Drawing,” at the Museum of Modern Art, is a mindblower of a show. More than 250 works on paper, among them dozens of watercolors, reveal Paul

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The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...