Synthesis Workshop
@synthesisworkshop.bsky.social
An open access content creation initiative in chemistry, featuring video podcast episodes, courses, problem sets, virtual research posters, and more. Homepage: synthesis-workshop.com
Reposted by Synthesis Workshop
Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky
Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
October 20, 2025 at 10:55 AM
Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky
Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
November 8, 2025 at 3:52 PM
Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli!
Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.
Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.
November 1, 2025 at 2:34 PM
We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli!
Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.
Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.
Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine!
Link: youtu.be/lzDv8cJRTyQ
Link: youtu.be/lzDv8cJRTyQ
October 18, 2025 at 3:34 PM
Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine!
Link: youtu.be/lzDv8cJRTyQ
Link: youtu.be/lzDv8cJRTyQ
Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
October 11, 2025 at 2:03 PM
Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!!
Link: youtu.be/6XD7dBUByyQ
Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...
Link: youtu.be/6XD7dBUByyQ
Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...
September 6, 2025 at 1:48 PM
Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!!
Link: youtu.be/6XD7dBUByyQ
Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...
Link: youtu.be/6XD7dBUByyQ
Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...
Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out!
Link: youtu.be/Hx8kVIsRlO4
Link: youtu.be/Hx8kVIsRlO4
A Crash Course on Cheminformatics with Dr. Fu Kit (Frederick) Sheong
YouTube video by Synthesis Workshop Videos
youtu.be
August 23, 2025 at 1:47 PM
Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out!
Link: youtu.be/Hx8kVIsRlO4
Link: youtu.be/Hx8kVIsRlO4
Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education!
Link: doi.org/10.1021/acs....
Link: doi.org/10.1021/acs....
Reimagining Advanced Chemistry Education: A Community-based Approach to Course Design for Modern Learners
Chemistry education at the graduate level and beyond faces the formidable challenge of a boundless and constantly expanding frontier of knowledge on many fronts. While modern learners have an increasi...
doi.org
August 15, 2025 at 2:17 PM
Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education!
Link: doi.org/10.1021/acs....
Link: doi.org/10.1021/acs....
Reposted by Synthesis Workshop
The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry.
Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...
Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...
Synthesis Workshop Videos
Synthesis Workshop is a channel dedicated to presenting advances in synthetic organic chemistry in an open-access format with concise explanations and clear visuals. Created by Matthew Horwitz, Ph.D.
www.youtube.com
August 11, 2025 at 8:06 AM
The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry.
Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...
Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...
Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing!
Link: youtu.be/D513hX1gOTg
@chemicalscience.rsc.org
doi.org/10.1039/D5SC...
Link: youtu.be/D513hX1gOTg
@chemicalscience.rsc.org
doi.org/10.1039/D5SC...
August 9, 2025 at 1:38 PM
Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing!
Link: youtu.be/D513hX1gOTg
@chemicalscience.rsc.org
doi.org/10.1039/D5SC...
Link: youtu.be/D513hX1gOTg
@chemicalscience.rsc.org
doi.org/10.1039/D5SC...
Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing!
Link: youtu.be/fnFfw9T5DTM
Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...
Link: youtu.be/fnFfw9T5DTM
Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...
Non-enzymatic Methylcyclization of Alkenes with Immanuel Plangger
YouTube video by Synthesis Workshop Videos
youtu.be
July 19, 2025 at 10:15 PM
Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing!
Link: youtu.be/fnFfw9T5DTM
Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...
Link: youtu.be/fnFfw9T5DTM
Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...
Very excited to announce that our recent review has been featured on the cover of Synthesis!!
If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...
If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...
July 18, 2025 at 2:31 PM
Very excited to announce that our recent review has been featured on the cover of Synthesis!!
If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...
If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...
Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!!
Link: youtu.be/hbrrRyy0zfU
Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...
Link: youtu.be/hbrrRyy0zfU
Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...
July 12, 2025 at 7:08 PM
Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!!
Link: youtu.be/hbrrRyy0zfU
Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...
Link: youtu.be/hbrrRyy0zfU
Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...
Reposted by Synthesis Workshop
Dive into chiral #DrugDevelopment 💊 This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬
👉 buff.ly/ganycgH
👉 buff.ly/ganycgH
July 2, 2025 at 7:01 AM
Dive into chiral #DrugDevelopment 💊 This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬
👉 buff.ly/ganycgH
👉 buff.ly/ganycgH
Join us today as Michael Zott and Daniel Zuschlag share their work with Prof. Dirk Trauner on the synthesis of isosteroidal alkaloids!!
youtu.be/Be-vVFLuGzE
Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...
youtu.be/Be-vVFLuGzE
Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...
Concise Synthesis of Isosteroidal Alkaloids with Michael Zott and Daniel Zuschlag
YouTube video by Synthesis Workshop Videos
youtu.be
June 21, 2025 at 2:39 PM
Join us today as Michael Zott and Daniel Zuschlag share their work with Prof. Dirk Trauner on the synthesis of isosteroidal alkaloids!!
youtu.be/Be-vVFLuGzE
Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...
youtu.be/Be-vVFLuGzE
Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...
Today Ömer Taşpınar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!!
Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...
Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...
June 4, 2025 at 7:42 PM
Today Ömer Taşpınar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!!
Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...
Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...
This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).
April 26, 2025 at 8:42 PM
This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).
Check out the latest installment in our Asymmetric Organocatalysis course!!
Link: youtu.be/pwtS9YWxldI
Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.
Link: youtu.be/pwtS9YWxldI
Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.
Introduction to Asymmetric Organocatalysis: Non-covalent Organocatalysis
YouTube video by Synthesis Workshop Videos
youtu.be
April 26, 2025 at 8:40 PM
Check out the latest installment in our Asymmetric Organocatalysis course!!
Link: youtu.be/pwtS9YWxldI
Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.
Link: youtu.be/pwtS9YWxldI
Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.
Join us this week as Rahul Giri shares his work on dual-functional group transfer reagents for the dihalogenation of hydrocarbons!! Thanks to Andy for hosting!
Link: youtu.be/eL7dFssUHcA
Link: youtu.be/eL7dFssUHcA
March 28, 2025 at 8:24 PM
Join us this week as Rahul Giri shares his work on dual-functional group transfer reagents for the dihalogenation of hydrocarbons!! Thanks to Andy for hosting!
Link: youtu.be/eL7dFssUHcA
Link: youtu.be/eL7dFssUHcA
Join us this week to hear from Dr. Feba Pulikkottil about her recently published work on eFluorination!!
Link: youtu.be/U6V6rYhMu1A
Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....
Link: youtu.be/U6V6rYhMu1A
Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....
eFluorination for the Rapid Synthesis of Carbamoyl Fluorides from Oxamic Acids
YouTube video by Synthesis Workshop Videos
youtu.be
March 22, 2025 at 2:21 PM
Join us this week to hear from Dr. Feba Pulikkottil about her recently published work on eFluorination!!
Link: youtu.be/U6V6rYhMu1A
Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....
Link: youtu.be/U6V6rYhMu1A
Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....
Join us today on Synthesis Workshop as Prahallad Meher shares his work on site-selective alkylation and acylation reactions on glycines and peptides!! Thanks to Matteo Balletti for hosting!
Link: youtu.be/D7GsRePvxSs
Key paper:
ACS Catal. 2024, 14, 18896-18906.
doi.org/10.1021/acsc...
Link: youtu.be/D7GsRePvxSs
Key paper:
ACS Catal. 2024, 14, 18896-18906.
doi.org/10.1021/acsc...
Site-selective Arylation and Alkylation of Glycines and Peptides with Prahallad Meher
YouTube video by Synthesis Workshop Videos
youtu.be
March 15, 2025 at 2:35 PM
Join us today on Synthesis Workshop as Prahallad Meher shares his work on site-selective alkylation and acylation reactions on glycines and peptides!! Thanks to Matteo Balletti for hosting!
Link: youtu.be/D7GsRePvxSs
Key paper:
ACS Catal. 2024, 14, 18896-18906.
doi.org/10.1021/acsc...
Link: youtu.be/D7GsRePvxSs
Key paper:
ACS Catal. 2024, 14, 18896-18906.
doi.org/10.1021/acsc...
Join us today as Nicolò Tampellini shares his recently published work on asymmetric cyclization reactions!!
Link: youtu.be/9e4Hxt5FjH4
J. Am. Chem. Soc. 2025, 147, 4624-4630.
doi.org/10.1021/jacs...
Link: youtu.be/9e4Hxt5FjH4
J. Am. Chem. Soc. 2025, 147, 4624-4630.
doi.org/10.1021/jacs...
March 8, 2025 at 2:32 PM
Join us today as Nicolò Tampellini shares his recently published work on asymmetric cyclization reactions!!
Link: youtu.be/9e4Hxt5FjH4
J. Am. Chem. Soc. 2025, 147, 4624-4630.
doi.org/10.1021/jacs...
Link: youtu.be/9e4Hxt5FjH4
J. Am. Chem. Soc. 2025, 147, 4624-4630.
doi.org/10.1021/jacs...
Also check out our new problem and solution set on synthetic electrochemistry, created by Dr. Peter Bellotti! Available for download for free on our project homepage in the Courses or Problem Set section (www.synthesis-workshop.com)!
March 5, 2025 at 9:16 PM
Also check out our new problem and solution set on synthetic electrochemistry, created by Dr. Peter Bellotti! Available for download for free on our project homepage in the Courses or Problem Set section (www.synthesis-workshop.com)!
Tune in for an ⚡⚡⚡ELECTRIFYING⚡⚡⚡ talk!
Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!!
Link: youtu.be/pBW4xHF2bBw
Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!!
Link: youtu.be/pBW4xHF2bBw
March 5, 2025 at 9:15 PM
Tune in for an ⚡⚡⚡ELECTRIFYING⚡⚡⚡ talk!
Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!!
Link: youtu.be/pBW4xHF2bBw
Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!!
Link: youtu.be/pBW4xHF2bBw
Welcome to the team!!!
Excited to join the Synthesis Workshop's editorial board! Huge thanks to @synthesisworkshop.bsky.social for the opportunity—looking forward to sharing and exploring more in organic synthesis. Let’s enjoy the chemistry! #OrganicSynthesis #SynthesisWorkshop
February 21, 2025 at 5:32 AM
Welcome to the team!!!