Pat Madden
@patmadden.bsky.social
Postdoc in the Crotty Lab at LJI studying HIV vaccines and B cell immunology
Reposted by Pat Madden
RFK Jr: "Two weeks ago we ended, under your leadership, a twenty year war on women".
Three out of five men in this shot have been accused of sexual misconduct, harassment or abusive behaviour towards women. A fourth signed into law a near-total abortion ban in his state as governor.
Three out of five men in this shot have been accused of sexual misconduct, harassment or abusive behaviour towards women. A fourth signed into law a near-total abortion ban in his state as governor.
December 2, 2025 at 6:46 PM
RFK Jr: "Two weeks ago we ended, under your leadership, a twenty year war on women".
Three out of five men in this shot have been accused of sexual misconduct, harassment or abusive behaviour towards women. A fourth signed into law a near-total abortion ban in his state as governor.
Three out of five men in this shot have been accused of sexual misconduct, harassment or abusive behaviour towards women. A fourth signed into law a near-total abortion ban in his state as governor.
Reposted by Pat Madden
This #WorldAIDSDay, help us call on Congress to fully fund federal HIV programs: idsociety.quorum.us/campaign/148...
December 1, 2025 at 4:21 PM
This #WorldAIDSDay, help us call on Congress to fully fund federal HIV programs: idsociety.quorum.us/campaign/148...
Reposted by Pat Madden
Fear and uncertainty hang over much of the HIV community this #WorldAIDSDay as we reflect on lives lost, progress made and current efforts to unravel our country’s HIV response. Action must follow our reflection this year.
Our statement: https://bit.ly/4ot4mOi
Our statement: https://bit.ly/4ot4mOi
December 1, 2025 at 2:56 PM
Fear and uncertainty hang over much of the HIV community this #WorldAIDSDay as we reflect on lives lost, progress made and current efforts to unravel our country’s HIV response. Action must follow our reflection this year.
Our statement: https://bit.ly/4ot4mOi
Our statement: https://bit.ly/4ot4mOi
Reposted by Pat Madden
SCOOP: The Trump administration has instructed employees and grantees not to use U.S. funds to commemorate World AIDS Day — because the observance was started by the World Health Organization.
www.nytimes.com/2025/11/26/h...
www.nytimes.com/2025/11/26/h...
Trump Administration Cancels U.S. Observance of World AIDS Day
www.nytimes.com
November 26, 2025 at 6:41 PM
SCOOP: The Trump administration has instructed employees and grantees not to use U.S. funds to commemorate World AIDS Day — because the observance was started by the World Health Organization.
www.nytimes.com/2025/11/26/h...
www.nytimes.com/2025/11/26/h...
Reposted by Pat Madden
As someone who has worked in HIV for 35+ years, I can tell you Carl is a consummate scientific leader. We’ve been lucky to have him at head of DAIDS. The only thing that wins here is the virus.
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 10:21 AM
As someone who has worked in HIV for 35+ years, I can tell you Carl is a consummate scientific leader. We’ve been lucky to have him at head of DAIDS. The only thing that wins here is the virus.
Reposted by Pat Madden
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 5:49 AM
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Reposted by Pat Madden
Absolutely. Even if he weren't a damaged creep, his approach to scientific evidence is completely disqualifying.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
November 21, 2025 at 3:10 PM
Absolutely. Even if he weren't a damaged creep, his approach to scientific evidence is completely disqualifying.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
Reposted by Pat Madden
Reposted by Pat Madden
From this minister's op-ed: "People wanting to experience God are more likely to meet the Divine trying to shut down the Broadview, Illinois, ICE facility than we ever were in church...God does not live in our houses of worship, but...with those who are bearing the brunt of cruelty in this moment."
Oh wow @reuters.com got the photo here:
November 14, 2025 at 9:38 PM
From this minister's op-ed: "People wanting to experience God are more likely to meet the Divine trying to shut down the Broadview, Illinois, ICE facility than we ever were in church...God does not live in our houses of worship, but...with those who are bearing the brunt of cruelty in this moment."
Reposted by Pat Madden
Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
November 12, 2025 at 8:05 PM
Happy to share our latest work! This study would not have been possible without the amazing Crotty Lab team, our collaborators at the Scripps CHAVD HIV vaccine consortia, and crucial support from NIH funding. Grateful to be part of this effort!
Reposted by Pat Madden
“We are doing a service for the United States because they’ve identified needs that need to be met,” says Harvard bioengineer Don Ingber, defending federal grants and contracts to universities for scientific and medical research. cbsn.ws/4hRoEiJ
November 10, 2025 at 12:27 AM
“We are doing a service for the United States because they’ve identified needs that need to be met,” says Harvard bioengineer Don Ingber, defending federal grants and contracts to universities for scientific and medical research. cbsn.ws/4hRoEiJ
Reposted by Pat Madden
Some charts for those who don't know the extent of the US public (and private) investment in research (particularly in biomedical research) compared to other countries and institutions. The destruction of the US' scientific institutions has global implications.
November 2, 2025 at 10:52 AM
Some charts for those who don't know the extent of the US public (and private) investment in research (particularly in biomedical research) compared to other countries and institutions. The destruction of the US' scientific institutions has global implications.
Reposted by Pat Madden
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 17, 2025 at 6:41 PM
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Pat Madden
Me in Vox.com on the need for ambitious global roll out of the revolutionary HIV prevention injection lenacapavir--and how Vought's theft of PEPFAR funding & State's Jeremy Lewin's weak approach and ideological bent will sabotage the effort--unless we fight back:
www.vox.com/future-perfe... >>
www.vox.com/future-perfe... >>
The only thing standing between humanity and the end of HIV
Even Trump is fast-tracking this innovative new drug. What could go wrong?
www.vox.com
October 14, 2025 at 8:20 PM
Me in Vox.com on the need for ambitious global roll out of the revolutionary HIV prevention injection lenacapavir--and how Vought's theft of PEPFAR funding & State's Jeremy Lewin's weak approach and ideological bent will sabotage the effort--unless we fight back:
www.vox.com/future-perfe... >>
www.vox.com/future-perfe... >>
Reposted by Pat Madden
🚨BREAKING:🚨 AIDS activists arrested occupying Senator Collins' DC office, demanding she stop GIVING IN to Russ Vought's illegal & deadly withholding of global HIV funding.
See: healthgap.org/press/aids-a...
Simultaneously, bodybags delivered to her Portland office by Maine activists 👇
See: healthgap.org/press/aids-a...
Simultaneously, bodybags delivered to her Portland office by Maine activists 👇
AIDS Activists Arrested at Sen. Collins’ Office, Demanding She Reverse Chokehold on Appropriated PEPFAR Funds for Lifesaving HIV Prevention and Treatment
Press StatementFor Immediate Release: October 14 2025Contact: Asia Russell, Health GAP: (267) 475 2645 | asia@healthgap.orgElizabeth Koke, Housing Works: (646) 342 9350 | e.koke@housingworks.orgMarie...
healthgap.org
October 14, 2025 at 4:23 PM
🚨BREAKING:🚨 AIDS activists arrested occupying Senator Collins' DC office, demanding she stop GIVING IN to Russ Vought's illegal & deadly withholding of global HIV funding.
See: healthgap.org/press/aids-a...
Simultaneously, bodybags delivered to her Portland office by Maine activists 👇
See: healthgap.org/press/aids-a...
Simultaneously, bodybags delivered to her Portland office by Maine activists 👇
Reposted by Pat Madden
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
www.biorxiv.org
July 21, 2025 at 2:48 PM
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pat Madden
These are the weak points. You know what to do. First thing tomorrow, use 5calls.org and raise hell.
July 2, 2025 at 3:31 AM
These are the weak points. You know what to do. First thing tomorrow, use 5calls.org and raise hell.
Reposted by Pat Madden
MERKLEY: How do you feel about being responsible for hundreds of thousands of kids dying because of your sudden interruption in these key programs?
VOUGHT: I reject the assertion
MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact
VOUGHT: I reject the assertion
MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact
June 25, 2025 at 8:03 PM
MERKLEY: How do you feel about being responsible for hundreds of thousands of kids dying because of your sudden interruption in these key programs?
VOUGHT: I reject the assertion
MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact
VOUGHT: I reject the assertion
MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact
Reposted by Pat Madden
Chris Murphy: "Trump & the Republicans are trying to engineer the most massive transfer of wealth from the poor & middle class to the wealthy in history of the country...that's super unpopular. So how do you pass it? You can only pass it if you also destroy democracy & the means of accountability"
June 25, 2025 at 9:22 PM
Chris Murphy: "Trump & the Republicans are trying to engineer the most massive transfer of wealth from the poor & middle class to the wealthy in history of the country...that's super unpopular. So how do you pass it? You can only pass it if you also destroy democracy & the means of accountability"
Reposted by Pat Madden
I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...
www.kpbs.org/podcasts/kpb...
Nobel laureate on how Trump's cuts are hurting science
Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...
www.kpbs.org
June 19, 2025 at 12:27 AM
I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...
www.kpbs.org/podcasts/kpb...
Reposted by Pat Madden
Robert F. Kennedy Jr. is a clear and present danger to every person in the United States, and in fact in entire world.
He must be REMOVED FROM OFFICE IMMEDIATELY.
He must be REMOVED FROM OFFICE IMMEDIATELY.
June 9, 2025 at 9:17 PM
Robert F. Kennedy Jr. is a clear and present danger to every person in the United States, and in fact in entire world.
He must be REMOVED FROM OFFICE IMMEDIATELY.
He must be REMOVED FROM OFFICE IMMEDIATELY.
Reposted by Pat Madden
~40% cuts to NIH research awards.
~35% cuts to training programs.
~27% cut to internal research.
~30% fewer grants awarded overall.
The Common Fund will be cut in half.
American science has never faced a threat like this.
www.statnews.com/2025/06/06/n... via @statnews.com
~35% cuts to training programs.
~27% cut to internal research.
~30% fewer grants awarded overall.
The Common Fund will be cut in half.
American science has never faced a threat like this.
www.statnews.com/2025/06/06/n... via @statnews.com
NIH details how Trump budget would cut support for grants, training, and research centers
President Trump's 2026 budget proposes cutting NIH grants to universities, academic medical centers, and other institutions by 43%
www.statnews.com
June 6, 2025 at 10:31 PM
~40% cuts to NIH research awards.
~35% cuts to training programs.
~27% cut to internal research.
~30% fewer grants awarded overall.
The Common Fund will be cut in half.
American science has never faced a threat like this.
www.statnews.com/2025/06/06/n... via @statnews.com
~35% cuts to training programs.
~27% cut to internal research.
~30% fewer grants awarded overall.
The Common Fund will be cut in half.
American science has never faced a threat like this.
www.statnews.com/2025/06/06/n... via @statnews.com
Reposted by Pat Madden
must be incredibly frustrating and disheartening to have federal funding that was promised to you for important work suddenly and arbitrarily ripped away
“In light of the President's statement about cancellation of my government contracts, @SpaceX will begin decommissioning its Dragon spacecraft immediately”
June 5, 2025 at 8:15 PM
must be incredibly frustrating and disheartening to have federal funding that was promised to you for important work suddenly and arbitrarily ripped away