Paraish S. Misra, MD PhD
@paraish.bsky.social
Transplant nephrologist
Research: pluripotent stem cells • organoids • regenerative med
Diabetes, transplantation & kidney disease
he/him • Views mine • No medical advice
Research: pluripotent stem cells • organoids • regenerative med
Diabetes, transplantation & kidney disease
he/him • Views mine • No medical advice
Reposted by Paraish S. Misra, MD PhD
So excited to hear about Hypoimmune islet transplants from Sonja Schrepfer from Sana Biotechnology - without immunosuppression
Is this the future for cell therapy in diabetes?
@albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP
Is this the future for cell therapy in diabetes?
@albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP
June 5, 2025 at 4:53 PM
So excited to hear about Hypoimmune islet transplants from Sonja Schrepfer from Sana Biotechnology - without immunosuppression
Is this the future for cell therapy in diabetes?
@albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP
Is this the future for cell therapy in diabetes?
@albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP
Reposted by Paraish S. Misra, MD PhD
Some chapters are harder to get out that others. This was like birthing an elephant. But it's great.
Channel your enthusiasm:
Chapter 19 part 1, Metabolic Acidosis
www.rosebook.club/episodes/202...
Channel your enthusiasm:
Chapter 19 part 1, Metabolic Acidosis
www.rosebook.club/episodes/202...
Chapter Nineteen, Part 1: Metabolic Acidosis, The Show — Channel Your Enthusiasm
Chapter 19: Metabolic Acidosis. Part One, The Show
www.rosebook.club
June 2, 2025 at 3:48 AM
Some chapters are harder to get out that others. This was like birthing an elephant. But it's great.
Channel your enthusiasm:
Chapter 19 part 1, Metabolic Acidosis
www.rosebook.club/episodes/202...
Channel your enthusiasm:
Chapter 19 part 1, Metabolic Acidosis
www.rosebook.club/episodes/202...
Pretty exciting! I wonder how long the effect will last…
Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
Adeno-Associated Virus-Mediated Transduction of PD-L1 in a Rodent Lung Transplant Model
Acute cellular rejection (ACR) is a key contributor to chronic lung allograft dysfunction
(CLAD) following transplantation; while treatable, traditional immunosuppressive (IS)
therapies are associated...
www.amjtransplant.org
May 30, 2025 at 6:16 PM
Pretty exciting! I wonder how long the effect will last…
Reposted by Paraish S. Misra, MD PhD
Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
Adeno-Associated Virus-Mediated Transduction of PD-L1 in a Rodent Lung Transplant Model
Acute cellular rejection (ACR) is a key contributor to chronic lung allograft dysfunction
(CLAD) following transplantation; while treatable, traditional immunosuppressive (IS)
therapies are associated...
www.amjtransplant.org
May 30, 2025 at 5:58 PM
Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...
Reposted by Paraish S. Misra, MD PhD
Well done! Congrats from the east 😎
Promoted! This one's for you Dad, miss you.
A huge thanks to all my wonderful and supportive colleagues, some anonymous, that helped with this!
A huge thanks to all my wonderful and supportive colleagues, some anonymous, that helped with this!
May 27, 2025 at 8:13 PM
Well done! Congrats from the east 😎
Reposted by Paraish S. Misra, MD PhD
🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy
Redirecting
doi.org
May 26, 2025 at 11:06 AM
🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy
Reposted by Paraish S. Misra, MD PhD
Interesting anecdote when a patient shows up with a ChatGPT differential diagnoses list 😏
www.ajkd.org/article/S027...
@ajkd.bsky.social
www.ajkd.org/article/S027...
@ajkd.bsky.social
Adapting to Artificial Intelligence in Nephrology Practice
I am an academic nephrologist practicing for more than 10 years in a tertiary medical
center. A 55-year-old man presented to my clinic with concerns about poor appetite
and abnormal kidney function pe...
www.ajkd.org
May 25, 2025 at 1:25 AM
Interesting anecdote when a patient shows up with a ChatGPT differential diagnoses list 😏
www.ajkd.org/article/S027...
@ajkd.bsky.social
www.ajkd.org/article/S027...
@ajkd.bsky.social
Reposted by Paraish S. Misra, MD PhD
A greater understanding of hypoxia’s impact on stem cell-derived #islets offering a potential intervention for clinical applications #T1D @natcomms.nature.com www.nature.com/articles/s41...
Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications
Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...
www.nature.com
May 23, 2025 at 10:09 AM
A greater understanding of hypoxia’s impact on stem cell-derived #islets offering a potential intervention for clinical applications #T1D @natcomms.nature.com www.nature.com/articles/s41...
Reposted by Paraish S. Misra, MD PhD
📢 Register now! Annual Transplant Research and Education Conference
📅Thurs June 5, 2025 - Fri June 6, 2025
📍Toronto (Virtual option available)
More details and to register: bit.ly/ATCEduResDay
@uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social
#education #transplant #research
📅Thurs June 5, 2025 - Fri June 6, 2025
📍Toronto (Virtual option available)
More details and to register: bit.ly/ATCEduResDay
@uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social
#education #transplant #research
May 21, 2025 at 5:26 PM
📢 Register now! Annual Transplant Research and Education Conference
📅Thurs June 5, 2025 - Fri June 6, 2025
📍Toronto (Virtual option available)
More details and to register: bit.ly/ATCEduResDay
@uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social
#education #transplant #research
📅Thurs June 5, 2025 - Fri June 6, 2025
📍Toronto (Virtual option available)
More details and to register: bit.ly/ATCEduResDay
@uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social
#education #transplant #research
Reposted by Paraish S. Misra, MD PhD
May 23, 2025 at 1:06 AM
Reposted by Paraish S. Misra, MD PhD
Excited to enroll our first participant for testing an agent (tolimidone) we hope will promote beta cell regeneration, building on preclinical work from Dr Jean Buteau at @albertadiabetes.bsky.social. Supported by Alberta Diabetes Foundation & biodexa pharmaceuticals www.ualberta.ca/en/folio/202...
Could a pill cure diabetes? A U of A researcher is working on it
A simple pill to treat or even cure diabetes could be possible, thanks to University of Alberta research — and funding that is laying vital groundwork.
www.ualberta.ca
May 15, 2025 at 5:42 PM
Excited to enroll our first participant for testing an agent (tolimidone) we hope will promote beta cell regeneration, building on preclinical work from Dr Jean Buteau at @albertadiabetes.bsky.social. Supported by Alberta Diabetes Foundation & biodexa pharmaceuticals www.ualberta.ca/en/folio/202...
Although a lot of work still to do, a great step forward for pluripotent stem cell-based therapies for kidney disease!
📣 NEW PAPER ALERT! 🧵
I love kidney organoids - tiny nephron clusters grown in the lab from pluripotent stem cells. But can they treat kidney disease? New data suggests they can (in mice)!
Let's dive in ⬇️
tinyurl.com/mr3sd6vu
#KidneyOrganoids #CellTherapy #ChronicKidneyDisease #AcuteKidneyInjury
I love kidney organoids - tiny nephron clusters grown in the lab from pluripotent stem cells. But can they treat kidney disease? New data suggests they can (in mice)!
Let's dive in ⬇️
tinyurl.com/mr3sd6vu
#KidneyOrganoids #CellTherapy #ChronicKidneyDisease #AcuteKidneyInjury
Human iPSC–derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models
Expanded human iPSC–derived nephron progenitor cells secrete renoprotective factors that have therapeutic potential for AKI and CKD.
tinyurl.com
May 20, 2025 at 1:04 PM
Although a lot of work still to do, a great step forward for pluripotent stem cell-based therapies for kidney disease!