Panos Poulis (currently in DE)
@panos-poulis.bsky.social
Joint @maxplanck.de & @weizmanninstitute.bsky.social fellow
mRNA recoding in cancer and RNA-based therapeutics, watching one molecule at a time
PhD @mpi-nat.bsky.social
mRNA recoding in cancer and RNA-based therapeutics, watching one molecule at a time
PhD @mpi-nat.bsky.social
Pinned
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!
cshperspectives.cshlp.org/content/earl...
Review alert! In our latest review, we dissect the mechanistic structural and kinetic principles that govern -1 ribosome frameshifting and discuss how different flavours arise from distinct molecular pathways, yet converge on shared mechanistic features.
Review alert! In our latest review, we dissect the mechanistic structural and kinetic principles that govern -1 ribosome frameshifting and discuss how different flavours arise from distinct molecular pathways, yet converge on shared mechanistic features.
Mechanisms and Determinants of −1 Ribosome Frameshifting and Bypassing
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences
cshperspectives.cshlp.org
October 6, 2025 at 6:59 PM
cshperspectives.cshlp.org/content/earl...
Review alert! In our latest review, we dissect the mechanistic structural and kinetic principles that govern -1 ribosome frameshifting and discuss how different flavours arise from distinct molecular pathways, yet converge on shared mechanistic features.
Review alert! In our latest review, we dissect the mechanistic structural and kinetic principles that govern -1 ribosome frameshifting and discuss how different flavours arise from distinct molecular pathways, yet converge on shared mechanistic features.
sfb1565.uni-goettingen.de/symposion/
The 1st Symposium on Interconnections in Gene Expression by SFB1565 with an exciting list of speakers will feature our recent research on how the pivotal N1-methylpseudouridine modification in mRNA compromises translation fidelity! Don't miss it!
The 1st Symposium on Interconnections in Gene Expression by SFB1565 with an exciting list of speakers will feature our recent research on how the pivotal N1-methylpseudouridine modification in mRNA compromises translation fidelity! Don't miss it!
1st Symposion: Interconnections and Cross-Regulation of Gene Expression Processes – SFB1565
sfb1565.uni-goettingen.de
September 1, 2025 at 7:45 AM
sfb1565.uni-goettingen.de/symposion/
The 1st Symposium on Interconnections in Gene Expression by SFB1565 with an exciting list of speakers will feature our recent research on how the pivotal N1-methylpseudouridine modification in mRNA compromises translation fidelity! Don't miss it!
The 1st Symposium on Interconnections in Gene Expression by SFB1565 with an exciting list of speakers will feature our recent research on how the pivotal N1-methylpseudouridine modification in mRNA compromises translation fidelity! Don't miss it!
Reposted by Panos Poulis (currently in DE)
ICYMI: New Online! Functions and therapeutic applications of pseudouridylation
Functions and therapeutic applications of pseudouridylation
Nature Reviews Molecular Cell Biology, Published online: 20 May 2025; doi:10.1038/s41580-025-00852-1Pseudouridine is a long-discovered RNA modification that has lately attracted much renewed interest. This Review discusses the emerging functions of pseudouridine in gene regulation and mitochondrial function, and its therapeutic potential following the successful use of pseudouridylation in SARS-CoV-2 mRNA vaccines.
bit.ly
May 23, 2025 at 9:07 AM
ICYMI: New Online! Functions and therapeutic applications of pseudouridylation
Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
March 27, 2025 at 5:12 PM
Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!
This is a promising study! Looking forward to the era that specific cancers could be prevented like infectious diseases. The more neoantigens we discover, the higher the variability of the vaccines!
A trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition and was associated with no recurrence in patients with high-risk clear cell renal cell carcinoma, according to a paper in Nature. #Medsky 🧪
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma - Nature
A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patients with high-risk clear cell renal cell carcinoma.
go.nature.com
February 16, 2025 at 12:32 PM
This is a promising study! Looking forward to the era that specific cancers could be prevented like infectious diseases. The more neoantigens we discover, the higher the variability of the vaccines!
It's the hook that matters 🪝 A great study by a good friend @eirinibellou.bsky.social and the pioneering @schuhlab.bsky.social !!! Amazing, truly intuitive images and invaluable insights with clinical perspectives! Congratulations!!!
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
December 23, 2024 at 2:39 PM
It's the hook that matters 🪝 A great study by a good friend @eirinibellou.bsky.social and the pioneering @schuhlab.bsky.social !!! Amazing, truly intuitive images and invaluable insights with clinical perspectives! Congratulations!!!
Reposted by Panos Poulis (currently in DE)
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
December 23, 2024 at 1:22 PM
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Reposted by Panos Poulis (currently in DE)
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
December 11, 2024 at 9:35 PM
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
These aspects are often overlooked in research. Our effort to design cancer therapeutics should be as delicate and complicated, as cancer and the human body are.
Researchers from the NKI, Oncode Institute & VIB KU Leuven CCB found that the menstrual cycle phase may influence the effectiveness of chemotherapy in breast cancer, highlighting the importance of research into the menstrual cycle & female-specific research ➡️ bit.ly/3Vp2MkO
December 5, 2024 at 2:19 PM
These aspects are often overlooked in research. Our effort to design cancer therapeutics should be as delicate and complicated, as cancer and the human body are.
Reposted by Panos Poulis (currently in DE)
EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie.
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
December 4, 2024 at 4:05 PM
EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie.
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
Another paper that shows the significance and therapeutic potential of aberrant translation in cancer. We have much more to learn from the ribosome!
Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer
Abstract. Messenger RNA (mRNA) translation is a tightly controlled process frequently deregulated in cancer. Key to this deregulation are transfer RNAs (tR
academic.oup.com
December 2, 2024 at 7:04 PM
Another paper that shows the significance and therapeutic potential of aberrant translation in cancer. We have much more to learn from the ribosome!
Reposted by Panos Poulis (currently in DE)
Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum
Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...
#LMBResearch
Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...
#LMBResearch
November 29, 2024 at 9:43 AM
Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum
Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...
#LMBResearch
Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...
#LMBResearch
The ribosome decodes, catalyzes and moves. Everything you need to know about the cellular machine that defines life itself, described by one of the founding fathers of ribosome biology.
The ribosome comes to life
The ribosome is an ancient molecular machine that coverts the genetic information
carried by mRNA into protein, a crucial step in linking genotype to phenotype. This
review discusses landmark advances...
www.cell.com
November 24, 2024 at 10:29 PM
The ribosome decodes, catalyzes and moves. Everything you need to know about the cellular machine that defines life itself, described by one of the founding fathers of ribosome biology.