Padmanee (Pam) Sharma, MD, PhD
@pamsharmamdphd.bsky.social
Immunologist. Oncologist. Mom. Wife. #endcancer
Reposted by Padmanee (Pam) Sharma, MD, PhD
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Padmanee (Pam) Sharma, MD, PhD
What a pleasure and honor to have the Nobel Prize @jimallisonphd.bsky.social and the brilliant @pamsharmamdphd.bsky.social at Regina Elena National Cancer Institute in Rome, for the Raffaele Tecce memorial lecture. Immuno past and future! #savelife
December 10, 2024 at 7:04 PM
What a pleasure and honor to have the Nobel Prize @jimallisonphd.bsky.social and the brilliant @pamsharmamdphd.bsky.social at Regina Elena National Cancer Institute in Rome, for the Raffaele Tecce memorial lecture. Immuno past and future! #savelife
Reposted by Padmanee (Pam) Sharma, MD, PhD
Submit your abstract by Dec. 19 (11:59pm MST) to secure a poster presentation spot at our Precision Oncology meeting. Connect with experts such as @pamsharmamdphd.bsky.social in precision medicine, cancer treatment, and health equity! hubs.ly/Q02_9vH10 #KSPrecisionOnc25
@mdanderson.bsky.social
@mdanderson.bsky.social
December 10, 2024 at 10:09 PM
Submit your abstract by Dec. 19 (11:59pm MST) to secure a poster presentation spot at our Precision Oncology meeting. Connect with experts such as @pamsharmamdphd.bsky.social in precision medicine, cancer treatment, and health equity! hubs.ly/Q02_9vH10 #KSPrecisionOnc25
@mdanderson.bsky.social
@mdanderson.bsky.social
Reposted by Padmanee (Pam) Sharma, MD, PhD
Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 9, 2024 at 11:04 AM
Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Reposted by Padmanee (Pam) Sharma, MD, PhD
Jim Allison, amazing leader and inspiration!
December 8, 2024 at 11:21 PM
Jim Allison, amazing leader and inspiration!
Reposted by Padmanee (Pam) Sharma, MD, PhD
Let’s see… David Baker and Victor Ambros! And Jim 🤓🧐
December 8, 2024 at 11:21 PM
Let’s see… David Baker and Victor Ambros! And Jim 🤓🧐
De novo protein synthesis for specific recognition of peptide-MHC complex! This represents the potential for significant advancement in the development of immunotherapies!
doi: doi.org/10.1101/2024...
doi: doi.org/10.1101/2024...
doi.org
December 9, 2024 at 6:40 AM
De novo protein synthesis for specific recognition of peptide-MHC complex! This represents the potential for significant advancement in the development of immunotherapies!
doi: doi.org/10.1101/2024...
doi: doi.org/10.1101/2024...
How many Nobel Laureates can you name? It was an absolute pleasure to spend time with friends, including Sid Mukherjee & Doug Hanahan & Sabeena Merchant, and to hear stories of science, dedication & teamwork that led to the Nobel Prize for these brilliant, compassionate, fun & badass individuals!
December 8, 2024 at 2:56 PM
How many Nobel Laureates can you name? It was an absolute pleasure to spend time with friends, including Sid Mukherjee & Doug Hanahan & Sabeena Merchant, and to hear stories of science, dedication & teamwork that led to the Nobel Prize for these brilliant, compassionate, fun & badass individuals!
Nobel Prize Lecture in Chemistry with incredible promise for the future to use AlphaFold & development of new proteins to improve treatments for diseases and provide sustainability for our planet! Congratulations to David Baker, John Jumper & Demis Hassabis @demishassabis.bsky.social
December 8, 2024 at 11:15 AM
Nobel Prize Lecture in Chemistry with incredible promise for the future to use AlphaFold & development of new proteins to improve treatments for diseases and provide sustainability for our planet! Congratulations to David Baker, John Jumper & Demis Hassabis @demishassabis.bsky.social
Reposted by Padmanee (Pam) Sharma, MD, PhD
Working on my end-of-year analysis for public health and came across this shocking statistic:
The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.
Influenza has been a leading cause of death in America almost every year since at least 1980.
The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.
Influenza has been a leading cause of death in America almost every year since at least 1980.
December 7, 2024 at 8:25 PM
Working on my end-of-year analysis for public health and came across this shocking statistic:
The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.
Influenza has been a leading cause of death in America almost every year since at least 1980.
The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today.
Influenza has been a leading cause of death in America almost every year since at least 1980.
Reposted by Padmanee (Pam) Sharma, MD, PhD
December 7, 2024 at 9:02 PM
Reposted by Padmanee (Pam) Sharma, MD, PhD
Nobel prize week, a yearly celebration of science.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.
December 7, 2024 at 9:02 PM
Nobel prize week, a yearly celebration of science.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.
Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.
Brilliant lectures today by Victor Ambros & Gary Ruvkun for 2024 Nobel Prize in Medicine! I learned a lot about the Worm Breeders Gazette 🪱
December 7, 2024 at 5:57 PM
Brilliant lectures today by Victor Ambros & Gary Ruvkun for 2024 Nobel Prize in Medicine! I learned a lot about the Worm Breeders Gazette 🪱
Reposted by Padmanee (Pam) Sharma, MD, PhD
🚨2024 VinFuture Special Prize for Innovators with Outstanding Achievements has been awarded to Professors Zelig Eshhar (Israel), Carl H. June, and Michel Sadelain (United States) @PennMedicine @vinfutureprize www.accesswire.com/951373/the-2...
December 6, 2024 at 9:43 PM
🚨2024 VinFuture Special Prize for Innovators with Outstanding Achievements has been awarded to Professors Zelig Eshhar (Israel), Carl H. June, and Michel Sadelain (United States) @PennMedicine @vinfutureprize www.accesswire.com/951373/the-2...
Back in Stockholm to celebrate Nobel Week with @jimallisonphd.bsky.social
Always so much fun!! 🤩❤️🥰💕
Always so much fun!! 🤩❤️🥰💕
December 6, 2024 at 9:54 PM
Back in Stockholm to celebrate Nobel Week with @jimallisonphd.bsky.social
Always so much fun!! 🤩❤️🥰💕
Always so much fun!! 🤩❤️🥰💕
Reposted by Padmanee (Pam) Sharma, MD, PhD
#Science 🔭 is awesome
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
The European Southern Observatory’s Very Large Telescope (ESO’s VLT) has taken the first ever image of a young, Sun-like star accompanied by two giant exoplanets. Images of systems with multiple exopl...
www.eso.org
December 5, 2024 at 1:18 AM
#Science 🔭 is awesome
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...
First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope
www.eso.org/public/news/...
Reposted by Padmanee (Pam) Sharma, MD, PhD
Intro time! I'm Hind, a mucosal #immunologist working in KU Leuven on mast cells in health and in gut disease.
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...
Single cell transcriptomics reveal mast cell heterogeneity in the human gut
Gut mast cells are key players in infection and inflammation, as well as in homeostasis. Mast cells regulate gastrointestinal (GI) function by controlling vascular and epithelial permeability, and int...
www.biorxiv.org
December 4, 2024 at 8:12 AM
Intro time! I'm Hind, a mucosal #immunologist working in KU Leuven on mast cells in health and in gut disease.
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...
Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq
www.biorxiv.org/content/10.1...
Reposted by Padmanee (Pam) Sharma, MD, PhD
Noor (@noorpratap.bsky.social) has been working on this for quite some time! It took a bit of work to figure out, but now you can map your scATAC-seq reads directly to the genome and sort and dedup them with alevin-fry-atac. You get a BED file with counts ready for downstream analysis! 1/
Alevin-fry-atac enables rapid and memory frugal mapping of single-cell ATAC-seq data using virtual colors for accurate genomic pseudoalignment https://www.biorxiv.org/content/10.1101/2024.11.27.625771v1
Alevin-fry-atac enables rapid and memory frugal mapping of single-cell ATAC-seq data using virtual colors for accurate genomic pseudoalignment https://www.biorxiv.org/content/10.1101/2024.11.27.625771v1
Ultrafast mapping of short reads to transcriptomic and metagenomic references via lightweight mappin
www.biorxiv.org
December 2, 2024 at 11:25 PM
Noor (@noorpratap.bsky.social) has been working on this for quite some time! It took a bit of work to figure out, but now you can map your scATAC-seq reads directly to the genome and sort and dedup them with alevin-fry-atac. You get a BED file with counts ready for downstream analysis! 1/
Reposted by Padmanee (Pam) Sharma, MD, PhD
Our new tradition every Thanksgiving. watching Jim Allison: Breakthrough movie. Must-watch, especially students interested in science and medicine. Modern day #superman (cape missing) who saves millions of lives. Inspirational
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR
December 1, 2024 at 3:15 PM
Our new tradition every Thanksgiving. watching Jim Allison: Breakthrough movie. Must-watch, especially students interested in science and medicine. Modern day #superman (cape missing) who saves millions of lives. Inspirational
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR
@jimallisonphd.bsky.social @pamsharmamdphd.bsky.social
amzn.to/4gdxXaR
Reposted by Padmanee (Pam) Sharma, MD, PhD
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 29, 2024 at 4:47 PM
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Reposted by Padmanee (Pam) Sharma, MD, PhD
Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
www.biorxiv.org
November 28, 2024 at 3:05 AM
Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Padmanee (Pam) Sharma, MD, PhD
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | NEJM
Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapi...
www.nejm.org
November 28, 2024 at 4:01 AM
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Padmanee (Pam) Sharma, MD, PhD
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
Reposted by Padmanee (Pam) Sharma, MD, PhD
Briefly re-reading this paper in preparation for giving my talk this morning at EMDS2024. Such a lovely paper. www.nature.com/articles/s41...
Tissue-resident B cells orchestrate macrophage polarisation and function - Nature Communications
The function of B cells in peripheral blood and secondary lymphoid organs has long been appreciated but whether and how they contribute to tissue immune homeostasis is lesser known. Non-lymphoid organ...
www.nature.com
November 27, 2024 at 6:49 AM
Briefly re-reading this paper in preparation for giving my talk this morning at EMDS2024. Such a lovely paper. www.nature.com/articles/s41...
Reposted by Padmanee (Pam) Sharma, MD, PhD
A new method to recover biological signal lost after data integration.
GitHub:
github.com/Janezjz/cell...
Nature Biotech Paper: www.nature.com/articles/s41...
GitHub:
github.com/Janezjz/cell...
Nature Biotech Paper: www.nature.com/articles/s41...
Recovery of biological signals lost in single-cell batch integration with CellANOVA - Nature Biotechnology
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.
www.nature.com
November 26, 2024 at 10:00 PM
A new method to recover biological signal lost after data integration.
GitHub:
github.com/Janezjz/cell...
Nature Biotech Paper: www.nature.com/articles/s41...
GitHub:
github.com/Janezjz/cell...
Nature Biotech Paper: www.nature.com/articles/s41...