Host Microbe interactions
@hostmicrobelit.bsky.social
Trying to keep up with the literature. Infection, microbiome, bioinformatics and multi-omics.
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis | Cell Host & Microbe @cellpress.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis
Various forms of solid tumors harbor intracellular bacteria, but the physiological consequences of these microorganisms are poorly understood. We show…
www.sciencedirect.com
December 10, 2024 at 11:05 AM
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis | Cell Host & Microbe @cellpress.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 | Cell Host & Microbe @cellpress.bsky.social
Gets us closer to mechanisms underpinning long COVID and potentially other post viral syndromes.
www.cell.com/cell-host-mi...
Gets us closer to mechanisms underpinning long COVID and potentially other post viral syndromes.
www.cell.com/cell-host-mi...
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, inducing inflammation, neurodegeneration-related changes, and increasing the brain’s vulnerability to further injury.
www.cell.com
December 10, 2024 at 8:01 AM
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 | Cell Host & Microbe @cellpress.bsky.social
Gets us closer to mechanisms underpinning long COVID and potentially other post viral syndromes.
www.cell.com/cell-host-mi...
Gets us closer to mechanisms underpinning long COVID and potentially other post viral syndromes.
www.cell.com/cell-host-mi...
Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 9, 2024 at 11:04 AM
Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social .
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
Very exciting technology 🔬 #science #research #omics
www.nature.com/articles/s41...
What do others think of this? I’m sceptical of any universal #microbiome signature. In this case they focus on genomes which “were detectable in more than 75% of the samples”. This seems very high to me but they found hundreds of genomes which met this threshold?
A core microbiome signature as an indicator of health | Cell
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
October 8, 2024 at 10:53 PM
What do others think of this? I’m sceptical of any universal #microbiome signature. In this case they focus on genomes which “were detectable in more than 75% of the samples”. This seems very high to me but they found hundreds of genomes which met this threshold?
A core microbiome signature as an indicator of health | Cell
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
October 8, 2024 at 7:50 AM
A core microbiome signature as an indicator of health | Cell
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases
www.cell.com/cell/fulltex...
Machine learning for microbiologists | Nature Reviews Microbiology
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". #microbology #machinelearning
www.nature.com/articles/s41...
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". #microbology #machinelearning
www.nature.com/articles/s41...
Machine learning for microbiologists - Nature Reviews Microbiology
In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...
www.nature.com
October 8, 2024 at 7:44 AM
Machine learning for microbiologists | Nature Reviews Microbiology
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". #microbology #machinelearning
www.nature.com/articles/s41...
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists". #microbology #machinelearning
www.nature.com/articles/s41...
Reposted by Host Microbe interactions
The September issue of The Lancet Microbe is now online:
www.thelancet.com/journals/lan...
The journal is #OpenAccess, so you are free to explore all of the content. But these hashtags offer a flavour: #malaria #CandidaAuris #AMR #tuberculosis #TB #microbiome #MERS #Chagas #syphilis
#OA
www.thelancet.com/journals/lan...
The journal is #OpenAccess, so you are free to explore all of the content. But these hashtags offer a flavour: #malaria #CandidaAuris #AMR #tuberculosis #TB #microbiome #MERS #Chagas #syphilis
#OA
September 4, 2024 at 9:01 AM
The September issue of The Lancet Microbe is now online:
www.thelancet.com/journals/lan...
The journal is #OpenAccess, so you are free to explore all of the content. But these hashtags offer a flavour: #malaria #CandidaAuris #AMR #tuberculosis #TB #microbiome #MERS #Chagas #syphilis
#OA
www.thelancet.com/journals/lan...
The journal is #OpenAccess, so you are free to explore all of the content. But these hashtags offer a flavour: #malaria #CandidaAuris #AMR #tuberculosis #TB #microbiome #MERS #Chagas #syphilis
#OA
The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions | FEBS Journal.
Comprehensive Review, summarizes evidence & highlights potential mechanisms. #Immunology #microbiome #openaccess
febs.onlinelibrary.wiley.com/doi/full/10....
Comprehensive Review, summarizes evidence & highlights potential mechanisms. #Immunology #microbiome #openaccess
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub-optimal in vulnerable populations. Her...
febs.onlinelibrary.wiley.com
October 7, 2024 at 6:52 AM
The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions | FEBS Journal.
Comprehensive Review, summarizes evidence & highlights potential mechanisms. #Immunology #microbiome #openaccess
febs.onlinelibrary.wiley.com/doi/full/10....
Comprehensive Review, summarizes evidence & highlights potential mechanisms. #Immunology #microbiome #openaccess
febs.onlinelibrary.wiley.com/doi/full/10....
Reposted by Host Microbe interactions
De novo discovery of conserved gene clusters in microbial genomes with Spacedust
www.biorxiv.org/content/10.1...
GitHub: github.com/soedinglab/s...
www.biorxiv.org/content/10.1...
GitHub: github.com/soedinglab/s...
October 4, 2024 at 9:55 PM
De novo discovery of conserved gene clusters in microbial genomes with Spacedust
www.biorxiv.org/content/10.1...
GitHub: github.com/soedinglab/s...
www.biorxiv.org/content/10.1...
GitHub: github.com/soedinglab/s...
Reposted by Host Microbe interactions
The march of the mRNA vaccines goes on. Clostridiodes difficile (C diff) next...
#IDSky #MicroSky #MedSky 🧪
www.science.org/doi/10.1126/...
#IDSky #MicroSky #MedSky 🧪
www.science.org/doi/10.1126/...
A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection
Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeti...
www.science.org
October 4, 2024 at 9:19 PM
The march of the mRNA vaccines goes on. Clostridiodes difficile (C diff) next...
#IDSky #MicroSky #MedSky 🧪
www.science.org/doi/10.1126/...
#IDSky #MicroSky #MedSky 🧪
www.science.org/doi/10.1126/...
microshades: An R Package for Improving Color Accessibility and Organization of Microbiome Data
#Microbiome #Rstats #metagenomics
journals.asm.org/doi/10.1128/...
#Microbiome #Rstats #metagenomics
journals.asm.org/doi/10.1128/...
October 6, 2024 at 9:14 AM
microshades: An R Package for Improving Color Accessibility and Organization of Microbiome Data
#Microbiome #Rstats #metagenomics
journals.asm.org/doi/10.1128/...
#Microbiome #Rstats #metagenomics
journals.asm.org/doi/10.1128/...
Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involving competition for nutrients | Microbiome
Compares ITS vs Metagen + demonstrates how to enrich for fungi using centrifugation.
microbiomejournal.biomedcentral.com/articles/10....
Compares ITS vs Metagen + demonstrates how to enrich for fungi using centrifugation.
microbiomejournal.biomedcentral.com/articles/10....
Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involvin...
Background The accuracy of internal-transcribed-spacer (ITS) and shotgun metagenomics has not been robustly evaluated, and the effect of diet on the composition and function of the bacterial and funga...
microbiomejournal.biomedcentral.com
December 19, 2023 at 11:01 PM
Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involving competition for nutrients | Microbiome
Compares ITS vs Metagen + demonstrates how to enrich for fungi using centrifugation.
microbiomejournal.biomedcentral.com/articles/10....
Compares ITS vs Metagen + demonstrates how to enrich for fungi using centrifugation.
microbiomejournal.biomedcentral.com/articles/10....
Microbiome diversity protects against pathogens by nutrient blocking | Science
I don't think this will be surprising to anyone in the field but nice to see it demonstrated in using a combination of in vitro and in vivo gnotobiotic experiments. #microbiome #science
www.science.org/doi/10.1126/...
I don't think this will be surprising to anyone in the field but nice to see it demonstrated in using a combination of in vitro and in vivo gnotobiotic experiments. #microbiome #science
www.science.org/doi/10.1126/...
Microbiome diversity protects against pathogens by nutrient blocking
Diverse communities of commensal gut bacteria collectively limit pathogen colonization by blocking nutrient access.
www.science.org
December 19, 2023 at 12:39 AM
Microbiome diversity protects against pathogens by nutrient blocking | Science
I don't think this will be surprising to anyone in the field but nice to see it demonstrated in using a combination of in vitro and in vivo gnotobiotic experiments. #microbiome #science
www.science.org/doi/10.1126/...
I don't think this will be surprising to anyone in the field but nice to see it demonstrated in using a combination of in vitro and in vivo gnotobiotic experiments. #microbiome #science
www.science.org/doi/10.1126/...
Spatial host–microbiome sequencing reveals niches in the mouse gut | Nature Biotechnology
SHM-seq - an all-sequencing-based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from a tissue
www.nature.com/articles/s41...
SHM-seq - an all-sequencing-based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from a tissue
www.nature.com/articles/s41...
Spatial host–microbiome sequencing reveals niches in the mouse gut - Nature Biotechnology
Spatial host–microbiome sequencing simultaneously profiles microbes and host transcriptomes from mouse colons.
www.nature.com
November 23, 2023 at 11:25 PM
Spatial host–microbiome sequencing reveals niches in the mouse gut | Nature Biotechnology
SHM-seq - an all-sequencing-based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from a tissue
www.nature.com/articles/s41...
SHM-seq - an all-sequencing-based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from a tissue
www.nature.com/articles/s41...
Machine learning for microbiologists | Nature Reviews Microbiology
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists".
www.nature.com/articles/s41...
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists".
www.nature.com/articles/s41...
Machine learning for microbiologists - Nature Reviews Microbiology
In this Review, Segata, Waldron and colleagues discuss important key concepts of machine learning that are relevant to microbiologists and provide them with a set of tools essential to apply machine l...
www.nature.com
November 22, 2023 at 11:08 PM
Machine learning for microbiologists | Nature Reviews Microbiology
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists".
www.nature.com/articles/s41...
"we examine the main machine learning concepts, tasks and applications that are relevant for experimental and clinical microbiologists".
www.nature.com/articles/s41...
Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra | Nature Microbiology
Resource based upon analysis of 2,229 HMP genomes. Identified candidates in-siliso and validated in-vitro.
www.nature.com/articles/s41...
Resource based upon analysis of 2,229 HMP genomes. Identified candidates in-siliso and validated in-vitro.
www.nature.com/articles/s41...
Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity sp...
An analysis of over 2,000 genomes from Human Microbiome Project metagenomic data led to the identification of several extended- and narrow-spectrum antibiotics against clinical multidrug-resistant pat...
www.nature.com
November 20, 2023 at 11:53 PM
Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra | Nature Microbiology
Resource based upon analysis of 2,229 HMP genomes. Identified candidates in-siliso and validated in-vitro.
www.nature.com/articles/s41...
Resource based upon analysis of 2,229 HMP genomes. Identified candidates in-siliso and validated in-vitro.
www.nature.com/articles/s41...
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans | Nature Medicine
Very impressive dataset from 1651 households in China looking at bacteria and fungi in sputum.
www.nature.com/articles/s41...
Very impressive dataset from 1651 households in China looking at bacteria and fungi in sputum.
www.nature.com/articles/s41...
The airway microbiome mediates the interaction between environmental exposure and respiratory health...
Examining the interplay of environmental exposure with the airway microbiome provides insights for possible intervention in lung health.
www.nature.com
November 20, 2023 at 11:38 AM
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans | Nature Medicine
Very impressive dataset from 1651 households in China looking at bacteria and fungi in sputum.
www.nature.com/articles/s41...
Very impressive dataset from 1651 households in China looking at bacteria and fungi in sputum.
www.nature.com/articles/s41...
Reposted by Host Microbe interactions
The Neuroscience School of Advanced Studies on "Microbiota🦠 & the Brain 🧠" will take place once again next May in wonderful Venice.
Limited places, they always fill fast.. All levels welcome from PhD student to Full Professor
www.neurosas.org/advanced-cou...
Limited places, they always fill fast.. All levels welcome from PhD student to Full Professor
www.neurosas.org/advanced-cou...
November 20, 2023 at 11:03 AM
The Neuroscience School of Advanced Studies on "Microbiota🦠 & the Brain 🧠" will take place once again next May in wonderful Venice.
Limited places, they always fill fast.. All levels welcome from PhD student to Full Professor
www.neurosas.org/advanced-cou...
Limited places, they always fill fast.. All levels welcome from PhD student to Full Professor
www.neurosas.org/advanced-cou...
High-resolution strain-level microbiome composition analysis from short reads | Microbiome
"we present a new strain-level composition analysis tool named StrainScan”
github.com/liaoherui/St...
microbiomejournal.biomedcentral.com/articles/10....
"we present a new strain-level composition analysis tool named StrainScan”
github.com/liaoherui/St...
microbiomejournal.biomedcentral.com/articles/10....
High-resolution strain-level microbiome composition analysis from short reads - Microbiome
Background Bacterial strains under the same species can exhibit different biological properties, making strain-level composition analysis an important step in understanding the dynamics of microbial c...
microbiomejournal.biomedcentral.com
November 20, 2023 at 12:57 AM
High-resolution strain-level microbiome composition analysis from short reads | Microbiome
"we present a new strain-level composition analysis tool named StrainScan”
github.com/liaoherui/St...
microbiomejournal.biomedcentral.com/articles/10....
"we present a new strain-level composition analysis tool named StrainScan”
github.com/liaoherui/St...
microbiomejournal.biomedcentral.com/articles/10....
Probiotic-guided CAR-T cells for solid tumor targeting | Science
Immunotherapy is generally less effective for solid tumours (e.g. colon cancer). This reports on using an engineered E. coli to help with this process. #microbiology #cancer
www.science.org/doi/10.1126/...
Immunotherapy is generally less effective for solid tumours (e.g. colon cancer). This reports on using an engineered E. coli to help with this process. #microbiology #cancer
www.science.org/doi/10.1126/...
Probiotic-guided CAR-T cells for solid tumor targeting
Engineered probiotics produce synthetic targets to facilitate immunotherapy of solid tumors by CAR T cells.
www.science.org
November 20, 2023 at 12:55 AM
Probiotic-guided CAR-T cells for solid tumor targeting | Science
Immunotherapy is generally less effective for solid tumours (e.g. colon cancer). This reports on using an engineered E. coli to help with this process. #microbiology #cancer
www.science.org/doi/10.1126/...
Immunotherapy is generally less effective for solid tumours (e.g. colon cancer). This reports on using an engineered E. coli to help with this process. #microbiology #cancer
www.science.org/doi/10.1126/...
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes | Science Translational Medicine
Large human shotgun metagenomcis study (n=440) from the Huttenhower lab.
www.science.org/doi/10.1126/...
Large human shotgun metagenomcis study (n=440) from the Huttenhower lab.
www.science.org/doi/10.1126/...
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arth...
Gut microbiome configurations and activity exhibit similarities across distinct types of inflammatory arthritis.
www.science.org
November 20, 2023 at 12:47 AM
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes | Science Translational Medicine
Large human shotgun metagenomcis study (n=440) from the Huttenhower lab.
www.science.org/doi/10.1126/...
Large human shotgun metagenomcis study (n=440) from the Huttenhower lab.
www.science.org/doi/10.1126/...
Antibiotic perturbations to the gut microbiome | Nature Reviews Microbiology
"We present an overview of the currently complex picture of treatment-induced changes to the microbial community"
www.nature.com/articles/s41...
"We present an overview of the currently complex picture of treatment-induced changes to the microbial community"
www.nature.com/articles/s41...
Antibiotic perturbations to the gut microbiome - Nature Reviews Microbiology
In this Review, Fishbein, Mahmud and Dantas discuss factors that influence restructuring of the gut microbiome on antibiotic exposure, and they explore promising therapeutic avenues aimed at minimizin...
www.nature.com
November 20, 2023 at 12:45 AM
Antibiotic perturbations to the gut microbiome | Nature Reviews Microbiology
"We present an overview of the currently complex picture of treatment-induced changes to the microbial community"
www.nature.com/articles/s41...
"We present an overview of the currently complex picture of treatment-induced changes to the microbial community"
www.nature.com/articles/s41...
Refugee from Xitter. Originally set up this account to force myself to stay up to date on the literature but became quite a fun hobby tbh 🤷♂️ I’ll start cross posting a bunch of stuff and see what the BlueSky community is like
November 20, 2023 at 12:44 AM
Refugee from Xitter. Originally set up this account to force myself to stay up to date on the literature but became quite a fun hobby tbh 🤷♂️ I’ll start cross posting a bunch of stuff and see what the BlueSky community is like