Oscar A Peña, PhD
@oscarapena.bsky.social
🔬 Postdoc @bristoluni 🇬🇧, using #zebrafish 🐠 to study wound healing & scarring for a @scarfreeworld | he/him/Dr
Reposted by Oscar A Peña, PhD
Our new paper on valve disease in aged #zebrafish is out! onlinelibrary.wiley.com/doi/10.1111/... This has been a long running collaborative effort with contributions from lots of great people!
Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease
Natural ageing in zebrafish results in spontaneous development of valvular degeneration in both the atrioventricular (AV) and bulboventricular (BV) valves. Aged zebrafish valves are larger and exhibi...
onlinelibrary.wiley.com
October 13, 2025 at 11:01 AM
Our new paper on valve disease in aged #zebrafish is out! onlinelibrary.wiley.com/doi/10.1111/... This has been a long running collaborative effort with contributions from lots of great people!
Reposted by Oscar A Peña, PhD
I'm very excited to share our latest work with #zebrafish published in @mucosalimmunol.bsky.social!! 🐟
www.sciencedirect.com/science/arti...
Here, we characterized a genetic model of intestinal epithelial cell ablation to study the cellular and molecular mechanisms of intestinal #regeneration....
www.sciencedirect.com/science/arti...
Here, we characterized a genetic model of intestinal epithelial cell ablation to study the cellular and molecular mechanisms of intestinal #regeneration....
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating intestinal disorders t…
www.sciencedirect.com
May 14, 2025 at 9:35 AM
I'm very excited to share our latest work with #zebrafish published in @mucosalimmunol.bsky.social!! 🐟
www.sciencedirect.com/science/arti...
Here, we characterized a genetic model of intestinal epithelial cell ablation to study the cellular and molecular mechanisms of intestinal #regeneration....
www.sciencedirect.com/science/arti...
Here, we characterized a genetic model of intestinal epithelial cell ablation to study the cellular and molecular mechanisms of intestinal #regeneration....
Reposted by Oscar A Peña, PhD
Great article by @kordinglab.bsky.social on "why causal knowledge is pragmatically possible".
The best arguments for causation--& only one we need--is pragmatic. Here pragmatic isn't weak/subjective, but connected to actual goals, utility & outcomes in the world.
medium.com/@kording/why...
The best arguments for causation--& only one we need--is pragmatic. Here pragmatic isn't weak/subjective, but connected to actual goals, utility & outcomes in the world.
medium.com/@kording/why...
Why Causal Knowledge Is Pragmatically Possible: Bridging Philosophical Skepticism and Scientific…
When we observe the world, we note that events consistently follow one another. As David Hume famously argued in An Enquiry Concerning…
medium.com
February 12, 2025 at 11:46 PM
Great article by @kordinglab.bsky.social on "why causal knowledge is pragmatically possible".
The best arguments for causation--& only one we need--is pragmatic. Here pragmatic isn't weak/subjective, but connected to actual goals, utility & outcomes in the world.
medium.com/@kording/why...
The best arguments for causation--& only one we need--is pragmatic. Here pragmatic isn't weak/subjective, but connected to actual goals, utility & outcomes in the world.
medium.com/@kording/why...
Reposted by Oscar A Peña, PhD
Our paper has now been published @elife.bsky.social 🎉🎉🎉
Check it out, especially if you are interested in the TCR repertoire and T cell development in the thymus
doi.org/10.7554/eLif...
Check it out, especially if you are interested in the TCR repertoire and T cell development in the thymus
doi.org/10.7554/eLif...
Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus
The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage includi...
doi.org
December 6, 2024 at 1:56 PM
Our paper has now been published @elife.bsky.social 🎉🎉🎉
Check it out, especially if you are interested in the TCR repertoire and T cell development in the thymus
doi.org/10.7554/eLif...
Check it out, especially if you are interested in the TCR repertoire and T cell development in the thymus
doi.org/10.7554/eLif...
Reposted by Oscar A Peña, PhD
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
Reposted by Oscar A Peña, PhD
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks!
📽️ youtu.be/avrmIs3vPUQ?...
📽️ youtu.be/avrmIs3vPUQ?...
BSDB - The Fascinating World of Developmental Biology (full length)
YouTube video by The Company of Biologists
youtu.be
November 9, 2024 at 10:06 AM
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks!
📽️ youtu.be/avrmIs3vPUQ?...
📽️ youtu.be/avrmIs3vPUQ?...
Reposted by Oscar A Peña, PhD
Scientists of any gender working in female-dominated disciplines receive lower scores during evaluation and are less likely to get funded.
elifesciences.org/digests/9761...
elifesciences.org/digests/9761...
Discrimination between disciplines
Scientists working in fields with a high proportion of women researchers receive lower scores during evaluation and are less likely to get funded, suggests new study.
elifesciences.org
September 6, 2024 at 1:48 PM
Scientists of any gender working in female-dominated disciplines receive lower scores during evaluation and are less likely to get funded.
elifesciences.org/digests/9761...
elifesciences.org/digests/9761...
Reposted by Oscar A Peña, PhD
Live imaging of zebrafish embryos reveals early differences in the genesis of the cells that become blood and immune cells, shedding light on how these precursors emerge from vessels. elifesciences.org/digests/9142...
Emerging blood and immune cells
Live imaging of zebrafish embryos reveals early differences in the genesis of the cells that become blood and immune cells, shedding light on how these precursors emerge from vessels.
elifesciences.org
May 31, 2024 at 12:07 PM
Live imaging of zebrafish embryos reveals early differences in the genesis of the cells that become blood and immune cells, shedding light on how these precursors emerge from vessels. elifesciences.org/digests/9142...
Reposted by Oscar A Peña, PhD
Any #zebrafish friends still swimming around on here? We’d love to follow you! #ThatsHowWeShoal
April 14, 2024 at 4:06 PM
Any #zebrafish friends still swimming around on here? We’d love to follow you! #ThatsHowWeShoal
Reposted by Oscar A Peña, PhD
For those who might be interested:
We discovered a novel molecular pathway that links #tryptophan metabolism and glutamate #kainate receptors (KAR) to resistance against lethal #bacterial infections in zebrafish.
www.biorxiv.org/content/10.1...
Please RT!
We discovered a novel molecular pathway that links #tryptophan metabolism and glutamate #kainate receptors (KAR) to resistance against lethal #bacterial infections in zebrafish.
www.biorxiv.org/content/10.1...
Please RT!
A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 28, 2023 at 7:28 PM
For those who might be interested:
We discovered a novel molecular pathway that links #tryptophan metabolism and glutamate #kainate receptors (KAR) to resistance against lethal #bacterial infections in zebrafish.
www.biorxiv.org/content/10.1...
Please RT!
We discovered a novel molecular pathway that links #tryptophan metabolism and glutamate #kainate receptors (KAR) to resistance against lethal #bacterial infections in zebrafish.
www.biorxiv.org/content/10.1...
Please RT!